A review emphasizing on utility of heptad repeat sequence as a tool to design pharmacologically safe peptide-based antibiotics
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| Názov: | A review emphasizing on utility of heptad repeat sequence as a tool to design pharmacologically safe peptide-based antibiotics |
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| Autori: | Vikas, Yadav, Misra, Richa |
| Prispievatelia: | Central Drug Research Institute, Kungliga Fysiografiska Sällskapet i Lund |
| Zdroj: | Biochimie. 191:126-139 |
| Informácie o vydavateľovi: | Elsevier BV, 2021. |
| Rok vydania: | 2021 |
| Predmety: | Repetitive Sequences, Amino Acid, 0301 basic medicine, Cytotoxicity, Anti-Bacterial Agents/chemistry, Antimicrobial Cationic Peptides/chemistry, Biochimie, biophysique & biologie moléculaire, Biochemistry, Sciences de la santé humaine, 03 medical and health sciences, Antimicrobial Cationic Peptides/therapeutic use, Humans, Human health sciences, Haematotoxicity, Pharmacy, pharmacology & toxicology, 0303 health sciences, Heptad repeat sequence, General Medicine, Pharmacie, pharmacologie & toxicologie, Life sciences, Anti-Bacterial Agents, 3. Good health, Anti-Bacterial Agents/therapeutic use, Leucine zipper motif, Drug Design, Sciences du vivant, Antimicrobial peptides, Phenylalanine zipper motif, Biochemistry, biophysics & molecular biology, Antimicrobial Cationic Peptides |
| Popis: | Extensive usage of antibiotics has created an unprecedented scenario of the rapid emergence of many drug-resistant bacteria, which has become an alarming public health concern around the globe. Search for better alternatives that are as efficacious as antibiotics led to the discovery of antimicrobial peptides (AMPs). These small cationic amphiphilic peptides have emerged as a promising option as antimicrobial agents, owing to their multifaceted implications against varied pathogens. Recent years have witnessed tremendous growth in research on AMPs resulting in them being tested in clinical trials of which six got approved for topical application. The relatively less successful outcome has been attributed to the poor cell selectivity shown by most of the naturally occurring AMPs. This drawback needs to be circumvented by identifying strategies to design safe and effective peptides. In the present review, we have emphasized the importance of heptad repeat sequence (leucine and/or phenylalanine zipper motif) as a tool that has shown great promise in remodeling the toxic AMPs to safe antimicrobial agents. |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 0300-9084 |
| DOI: | 10.1016/j.biochi.2021.09.001 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/34492334 https://pubmed.ncbi.nlm.nih.gov/34492334/ https://portal.research.lu.se/en/publications/a-review-emphasizing-on-utility-of-heptad-repeat-sequence-as-a-to https://www.sciencedirect.com/science/article/pii/S0300908421002042 https://lup.lub.lu.se/search/publication/1876ff6d-36ab-4363-aae7-a9835ccd628e |
| Rights: | CC BY |
| Prístupové číslo: | edsair.doi.dedup.....4706f4575c71c075ce0aea53255a177d |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Extensive usage of antibiotics has created an unprecedented scenario of the rapid emergence of many drug-resistant bacteria, which has become an alarming public health concern around the globe. Search for better alternatives that are as efficacious as antibiotics led to the discovery of antimicrobial peptides (AMPs). These small cationic amphiphilic peptides have emerged as a promising option as antimicrobial agents, owing to their multifaceted implications against varied pathogens. Recent years have witnessed tremendous growth in research on AMPs resulting in them being tested in clinical trials of which six got approved for topical application. The relatively less successful outcome has been attributed to the poor cell selectivity shown by most of the naturally occurring AMPs. This drawback needs to be circumvented by identifying strategies to design safe and effective peptides. In the present review, we have emphasized the importance of heptad repeat sequence (leucine and/or phenylalanine zipper motif) as a tool that has shown great promise in remodeling the toxic AMPs to safe antimicrobial agents. |
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| ISSN: | 03009084 |
| DOI: | 10.1016/j.biochi.2021.09.001 |