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Ascitic fluid infection in patients with hepatitis B virus‐related liver cirrhosis: Culture‐negative neutrocytic ascites versus spontaneous bacterial peritonitis

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Title: Ascitic fluid infection in patients with hepatitis B virus‐related liver cirrhosis: Culture‐negative neutrocytic ascites versus spontaneous bacterial peritonitis
Authors: Chae Yoon Chon, Sang Hoon Ahn, Jun Yong Park, Hee Man Kim, Seung Up Kim, Chun Kyon Lee, Sinyoung Kim, Sun Hye Kim, Eunhee Choi, Do Young Kim, Kwang Hyub Han
Contributors: Seung Up Kim, Do Young Kim, Chun Kyon Lee, Jun Yong Park, Sun Hye Kim, Hee Man Kim, Eun Hee Choi, Sinyoung Kim, Kwang-Hyub Han, Chae Yoon Chon, Sang Hoon Ahn, Kim, Sin Young, Kim, Hee Man, Park, Jun Yong, Ahn, Sang Hoon, Chon, Chae Yoon, Choi, Eun Hee, Han, Kwang Hyup, Kim, Do Young, Kim, Seung Up
Source: Journal of Gastroenterology and Hepatology. 25:122-128
Publisher Information: Wiley, 2009.
Publication Year: 2009
Subject Terms: Liver Cirrhosis, Male, Time Factors, liver cirrhosis, Peritonitis/therapy, Kaplan-Meier Estimate, Hepatitis B/therapy, Peritonitis, culture-negative neutrocytic ascites, survival, Risk Assessment, Severity of Illness Index, ascites, 03 medical and health sciences, 0302 clinical medicine, Ascites/therapy, Risk Factors, Liver Cirrhosis/therapy, Liver Cirrhosis/virology, Peritonitis/mortality, Peritonitis/microbiology, Ascitic Fluid, Humans, Paracentesis, Hospital Mortality, Proportional Hazards Models, Hepatitis B/complications, Korea/epidemiology, Korea, Ascites/microbiology, Patient Selection, Ascites, Middle Aged, Hepatitis B, Ascites/mortality, Liver Transplantation, 3. Good health, spontaneous bacterial peritonitis, Ascitic Fluid/microbiology, Treatment Outcome, Logistic Models, Hepatitis B/mortality, Hepatitis B/diagnosis, Female, prognosis, Liver Cirrhosis/mortality, hepatitis B virus
Description: Background and Aim: Ascitic fluid infection (AFI) consists of culture‐negative neutrocytic ascites (CNNA) and spontaneous bacterial peritonitis (SBP). The present study compared the clinical characteristics and prognosis of CNNA and SBP in hepatitis B virus (HBV)‐related cirrhotic patients.Methods: We analyzed 130 consecutive patients hospitalized due to the first episode of AFI between January 1998 and December 2007.Results: The mean age of the patients was 52.3 years (88 men, 42 women). Ninety‐three patients (71.5%) had CNNA and 37 patients (28.5%) had SBP; 117 patients (90.0%) died after a median survival period of 6.4 months. Patients with CNNA and SBP survived for a median period of 6.9 months and 5.4 months, respectively (P = 0.417). Patients with SBP showed higher in‐hospital mortality than those with CNNA (16.2 vs 4.3%; P = 0.031). Binary logistic regression analysis showed that culture positivity of ascitic fluid (CNNA vs SBP) was the only independent predictor of in‐hospital mortality (P = 0.042). In a Cox regression model for the 120 patients (92.3%) who survived the first episode of AFI, only the Child–Pugh score remained significant for survival (P = 0.007), whereas no association was observed for culture positivity of ascitic fluid (CNNA vs SBP) during the first episode of AFI (P = 0.752).Conclusions: Although in‐hospital mortality was higher in patients with SBP than CNNA, the clinical course of the two groups was similar after the first episode of AFI. Thus, liver transplantation should be considered, irrespective of culture positivity of ascitic fluid.
Document Type: Article
File Description: 122~128
Language: English
ISSN: 1440-1746
0815-9319
DOI: 10.1111/j.1440-1746.2009.05970.x
Access URL: https://pubmed.ncbi.nlm.nih.gov/19845823
https://www.cabdirect.org/abstracts/20103035623.html
http://europepmc.org/abstract/MED/19845823
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1440-1746.2009.05970.x
https://mdanderson.elsevierpure.com/en/publications/ascitic-fluid-infection-in-patients-with-hepatitis-b-virus-relate
https://www.cabdirect.org/cabdirect/abstract/20103035623
https://www.ncbi.nlm.nih.gov/pubmed/19845823
Rights: Wiley Online Library User Agreement
CC BY NC ND
Accession Number: edsair.doi.dedup.....46a8c3ae6e164e42ba390fd151fbbb7d
Database: OpenAIRE
Description
Abstract:Background and Aim: Ascitic fluid infection (AFI) consists of culture‐negative neutrocytic ascites (CNNA) and spontaneous bacterial peritonitis (SBP). The present study compared the clinical characteristics and prognosis of CNNA and SBP in hepatitis B virus (HBV)‐related cirrhotic patients.Methods: We analyzed 130 consecutive patients hospitalized due to the first episode of AFI between January 1998 and December 2007.Results: The mean age of the patients was 52.3 years (88 men, 42 women). Ninety‐three patients (71.5%) had CNNA and 37 patients (28.5%) had SBP; 117 patients (90.0%) died after a median survival period of 6.4 months. Patients with CNNA and SBP survived for a median period of 6.9 months and 5.4 months, respectively (P = 0.417). Patients with SBP showed higher in‐hospital mortality than those with CNNA (16.2 vs 4.3%; P = 0.031). Binary logistic regression analysis showed that culture positivity of ascitic fluid (CNNA vs SBP) was the only independent predictor of in‐hospital mortality (P = 0.042). In a Cox regression model for the 120 patients (92.3%) who survived the first episode of AFI, only the Child–Pugh score remained significant for survival (P = 0.007), whereas no association was observed for culture positivity of ascitic fluid (CNNA vs SBP) during the first episode of AFI (P = 0.752).Conclusions: Although in‐hospital mortality was higher in patients with SBP than CNNA, the clinical course of the two groups was similar after the first episode of AFI. Thus, liver transplantation should be considered, irrespective of culture positivity of ascitic fluid.
ISSN:14401746
08159319
DOI:10.1111/j.1440-1746.2009.05970.x