Angiotensin-converting enzyme inhibitor use and pneumonia risk in a general population
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| Titel: | Angiotensin-converting enzyme inhibitor use and pneumonia risk in a general population |
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| Autoren: | van de Garde, E M W, Souverein, P C, van den Bosch, J M M, Deneer, V H M, Leufkens, H G M |
| Weitere Verfasser: | Afd Pharmacoepi & Clinical Pharmacology, Sub General Molecular Pharmacy |
| Quelle: | European Respiratory Journal. 27:1217-1222 |
| Verlagsinformationen: | European Respiratory Society (ERS), 2006. |
| Publikationsjahr: | 2006 |
| Schlagwörter: | Adult, Male, Angiotensin II Type 1 Receptor Blockers/therapeutic use, Statistics as Topic, Angiotensin-Converting Enzyme Inhibitors, Comorbidity, Community-Acquired Infections/epidemiology, Patient Admission/statistics & numerical data, Risk Assessment, Pneumonia, Bacterial/epidemiology, 03 medical and health sciences, Patient Admission, 0302 clinical medicine, Pneumococcal/epidemiology, SDG 3 - Good Health and Well-being, Bronchopneumonia/epidemiology, Pneumonia, Pneumococcal/epidemiology, 80 and over, Bronchopneumonia, Odds Ratio, Pneumonia, Bacterial, Humans, Bacterial/epidemiology, Aged, Aged, 80 and over, Incidence, Pneumonia, Middle Aged, Pneumonia, Pneumococcal, 3. Good health, Community-Acquired Infections, Angiotensin-Converting Enzyme Inhibitors/therapeutic use, Cross-Sectional Studies, Case-Control Studies, Female, Medical Record Linkage, Angiotensin II Type 1 Receptor Blockers |
| Beschreibung: | The aim of the present study was to assess whether the use of angiotensin-converting enzyme (ACE) inhibitors is associated with a decreased risk of hospitalisation for community-acquired pneumonia (CAP) in a general, essentially white population.Data were obtained from the Dutch PHARMO Record Linkage System. Cases were defined as patients with a first hospital admission for CAP. For each case, up to four population controls were matched by age and sex.The study population comprised 1,108 patients with a first hospital admission for CAP and 3,817 matched controls. After adjusting for several confounders, ACE inhibitor use was not associated with a decreased incidence of pneumonia (adjusted odds ratio (OR) 1.12; 95% confidence interval (CI) 0.88–1.43). Additionally, no significant association was observed in patients with diabetes, respiratory diseases, heart failure, or patients with both of the last two conditions. Furthermore, adjustment of treatment effects on pneumonia risk using stratification on balancing score also showed no significant association between ACE inhibitor use and pneumonia risk within the different strata (overall adjusted OR 1.09; 95% CI 0.87–1.36).In contrast with previous findings in Asian populations, the current authors were not able to confirm the beneficial effect of angiotensin-converting enzyme inhibitors on pneumonia risk in a general, essentially white population. |
| Publikationsart: | Article |
| Dateibeschreibung: | application/pdf |
| Sprache: | English |
| ISSN: | 1399-3003 0903-1936 |
| DOI: | 10.1183/09031936.06.00110005 |
| Zugangs-URL: | http://erj.ersjournals.com/content/27/6/1217.full.pdf https://pubmed.ncbi.nlm.nih.gov/16455828 https://research-portal.uu.nl/en/publications/cd1d58a8-12d0-4678-b9a5-1801030aa9ec https://doi.org/10.1183/09031936.06.00110005 https://erj.ersjournals.com/content/27/6/1217 http://erj.ersjournals.com/content/early/2006/02/02/09031936.06.00110005 https://core.ac.uk/display/39723477 https://dspace.library.uu.nl/handle/1874/27333 https://dspace.library.uu.nl/bitstream/handle/1874/27333/garde_07_angiotensinconvertingenzymeinhibitoruse.pdf?sequence=1 http://dspace.library.uu.nl/bitstream/1874/27333/1/garde_07_angiotensinconvertingenzymeinhibitoruse.pdf https://dspace.library.uu.nl/handle/1874/27333 |
| Dokumentencode: | edsair.doi.dedup.....46a6d2a4adb6572fe79fbae631ec628a |
| Datenbank: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstract: | The aim of the present study was to assess whether the use of angiotensin-converting enzyme (ACE) inhibitors is associated with a decreased risk of hospitalisation for community-acquired pneumonia (CAP) in a general, essentially white population.Data were obtained from the Dutch PHARMO Record Linkage System. Cases were defined as patients with a first hospital admission for CAP. For each case, up to four population controls were matched by age and sex.The study population comprised 1,108 patients with a first hospital admission for CAP and 3,817 matched controls. After adjusting for several confounders, ACE inhibitor use was not associated with a decreased incidence of pneumonia (adjusted odds ratio (OR) 1.12; 95% confidence interval (CI) 0.88–1.43). Additionally, no significant association was observed in patients with diabetes, respiratory diseases, heart failure, or patients with both of the last two conditions. Furthermore, adjustment of treatment effects on pneumonia risk using stratification on balancing score also showed no significant association between ACE inhibitor use and pneumonia risk within the different strata (overall adjusted OR 1.09; 95% CI 0.87–1.36).In contrast with previous findings in Asian populations, the current authors were not able to confirm the beneficial effect of angiotensin-converting enzyme inhibitors on pneumonia risk in a general, essentially white population. |
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| ISSN: | 13993003 09031936 |
| DOI: | 10.1183/09031936.06.00110005 |