Insects are a viable protein source for human consumption: from insect protein digestion to postprandial muscle protein synthesis in vivo in humans: a double-blind randomized trial: from insect protein digestion to postprandial muscle protein synthesis in vivo in humans: a double-blind randomized trial
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| Title: | Insects are a viable protein source for human consumption: from insect protein digestion to postprandial muscle protein synthesis in vivo in humans: a double-blind randomized trial: from insect protein digestion to postprandial muscle protein synthesis in vivo in humans: a double-blind randomized trial |
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| Authors: | Wesley JH Hermans, Joan M Senden, Tyler A Churchward-Venne, Kevin JM Paulussen, Cas J Fuchs, Joey SJ Smeets, Joop JA van Loon, Lex B Verdijk, Luc JC van Loon |
| Contributors: | Physiotherapy, Human Physiology and Anatomy, Human Physiology and Sports Physiotherapy Research Group |
| Source: | Am J Clin Nutr |
| Publisher Information: | Elsevier BV, 2021. |
| Publication Year: | 2021 |
| Subject Terms: | Adult, Male, 0301 basic medicine, Gene Expression Regulation/drug effects, stable isotopes, Muscle Proteins, Dietary Proteins/administration & dosage, Young Adult, 03 medical and health sciences, Double-Blind Method, milk protein, SYNTHESIS RATES, FSR, Animals, Humans, AMINO-ACIDS, RESISTANCE EXERCISE, Tenebrio, Exercise, Muscle Proteins/genetics, 2. Zero hunger, 0303 health sciences, intrinsically labeled protein, exercise, DIETARY-PROTEIN, Milk Proteins, Postprandial Period, Milk Proteins/administration & dosage, Original Research Communications, Gene Expression Regulation, protein metabolism, WHEY, YOUNG, young adult, SKELETAL-MUSCLE, NUTRITION, Dietary Proteins, INTRINSICALLY LABELED MILK, Tenebrio/chemistry, INGESTION |
| Description: | Insects have recently been identified as a more sustainable protein-dense food source and may represent a viable alternative to conventional animal-derived proteins.We aimed to compare the impacts of ingesting lesser mealworm- and milk-derived protein on protein digestion and amino acid absorption kinetics, postprandial skeletal muscle protein synthesis rates, and the incorporation of dietary protein-derived amino acids into de novo muscle protein at rest and during recovery from exercise in vivo in humans.In this double-blind randomized controlled trial, 24 healthy, young men ingested 30 g specifically produced, intrinsically l-[1-13C]-phenylalanine and l-[1-13C]-leucine labeled lesser mealworm- or milk-derived protein after a unilateral bout of resistance-type exercise. Primed continuous l-[ring-2H5]-phenylalanine, l-[ring-3,5-2H2]-tyrosine, and l-[1-13C]-leucine infusions were applied, with frequent collection of blood and muscle tissue samples.A total of 73% ± 7% and 77% ± 7% of the lesser mealworm and milk protein-derived phenylalanine was released into the circulation during the 5 h postprandial period, respectively, with no significant differences between groups (P 0.05). Incorporation of mealworm and milk protein-derived l-[1-13C]-phenylalanine into de novo muscle protein was greater after exercise than at rest (P 0.05).Ingestion of a meal-like amount of lesser mealworm-derived protein is followed by rapid protein digestion and amino acid absorption and increases muscle protein synthesis rates both at rest and during recovery from exercise. The postprandial protein handling of lesser mealworm does not differ from ingesting an equivalent amount of milk protein concentrate in vivo in humans.This trial was registered at www.trialregister.nl as NL6897. |
| Document Type: | Article Other literature type |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 0002-9165 |
| DOI: | 10.1093/ajcn/nqab115 |
| Access URL: | https://academic.oup.com/ajcn/article-pdf/114/3/934/40180525/nqab115.pdf https://pubmed.ncbi.nlm.nih.gov/34020450 https://www.narcis.nl/publication/RecordID/oai%3Alibrary.wur.nl%3Awurpubs%2F588768 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408844 https://cris.maastrichtuniversity.nl/en/publications/insects-are-a-viable-protein-source-for-human-consumption-from-in https://www.ncbi.nlm.nih.gov/pubmed/34020450 https://pubmed.ncbi.nlm.nih.gov/34020450/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408844 https://acuresearchbank.acu.edu.au/item/8x133/insects-are-a-viable-protein-source-for-human-consumption-from-insect-protein-digestion-to-postprandial-muscle-protein-synthesis-in-vivo-in-humans-a-double-blind-randomized-trial https://biblio.vub.ac.be/vubir/(e9a2b74d-e36b-490d-b2d3-4ba75d35d8d1).html |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited |
| Accession Number: | edsair.doi.dedup.....452ac9136b62c4c7cc7da9dbb91f22be |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Insects have recently been identified as a more sustainable protein-dense food source and may represent a viable alternative to conventional animal-derived proteins.We aimed to compare the impacts of ingesting lesser mealworm- and milk-derived protein on protein digestion and amino acid absorption kinetics, postprandial skeletal muscle protein synthesis rates, and the incorporation of dietary protein-derived amino acids into de novo muscle protein at rest and during recovery from exercise in vivo in humans.In this double-blind randomized controlled trial, 24 healthy, young men ingested 30 g specifically produced, intrinsically l-[1-13C]-phenylalanine and l-[1-13C]-leucine labeled lesser mealworm- or milk-derived protein after a unilateral bout of resistance-type exercise. Primed continuous l-[ring-2H5]-phenylalanine, l-[ring-3,5-2H2]-tyrosine, and l-[1-13C]-leucine infusions were applied, with frequent collection of blood and muscle tissue samples.A total of 73% ± 7% and 77% ± 7% of the lesser mealworm and milk protein-derived phenylalanine was released into the circulation during the 5 h postprandial period, respectively, with no significant differences between groups (P 0.05). Incorporation of mealworm and milk protein-derived l-[1-13C]-phenylalanine into de novo muscle protein was greater after exercise than at rest (P 0.05).Ingestion of a meal-like amount of lesser mealworm-derived protein is followed by rapid protein digestion and amino acid absorption and increases muscle protein synthesis rates both at rest and during recovery from exercise. The postprandial protein handling of lesser mealworm does not differ from ingesting an equivalent amount of milk protein concentrate in vivo in humans.This trial was registered at www.trialregister.nl as NL6897. |
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| ISSN: | 00029165 |
| DOI: | 10.1093/ajcn/nqab115 |