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Brain microdialysis to assess trace elements dynamics in traumatic brain injury: An exploratory study

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Title: Brain microdialysis to assess trace elements dynamics in traumatic brain injury: An exploratory study
Authors: Adriano Bernini, Sébastien Lenglet, Mette M. Berger, Samia Abed-Maillard, Roy Thomas Daniel, Mahmoud Messerer, Mauro Oddo, Jean-Daniel Chiche, Marc Augsburger, Nawfel Ben-Hamouda
Source: PLoS One
PLoS ONE, Vol 20, Iss 6, p e0326023 (2025)
PLoS ONE, Vol 20, Iss 6 (2025)
PloS one, vol. 20, no. 6, pp. e0326023
Publisher Information: Public Library of Science (PLoS), 2025.
Publication Year: 2025
Subject Terms: Humans, Brain Injuries, Traumatic/metabolism, Brain Injuries, Traumatic/blood, Microdialysis/methods, Trace Elements/metabolism, Trace Elements/blood, Trace Elements/analysis, Male, Female, Middle Aged, Adult, Brain/metabolism, Aged, Young Adult, Zinc/blood, Copper/blood, Copper/metabolism, Selenium/blood, Selenium/metabolism, Science, Medicine, Research Article
Description: Background Trace elements (TEs) status alterations in the brain have been linked to neurodegenerative diseases. However, data on TEs in living humans and in the post-traumatic conditions are scarce. Some TEs (copper – Cu, selenium – Se, zinc – Zn) are involved in essential antioxidant defence. This study aims to measure the evolution of TEs concentrations in the brain and serum of severe traumatic brain injury (TBI) patients over time. Methods Twenty adult patients with severe TBI were monitored using cerebral microdialysis (CMD) and blood sampling within three days of intensive care unit admission. TEs levels were measured using inductively coupled plasma system coupled to mass spectrometry. Results TEs concentrations of chromium – Cr, Cu, cobalt – Co, manganese – Mn, molybdenum – Mo, Se, and Zn were quantified in brain interstitial fluid and serum. While serum and CMD levels did not differ significantly for Co, Mo and Mn, and modest differences was observed for Cr and Zn, significant differences were observed for Cu and Se with higher serum levels (8–10-fold higher) compared to CMD. No correlation was found between serum and brain TEs levels, except for Mo. Conclusion This study provides novel TEs concentration data in living TBI patients, the largest differences between brain and serum being observed for Cu and Se, serving as a basis for further research on TEs dynamics in acute brain injury.
Document Type: Article
Other literature type
File Description: application/pdf
Language: English
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0326023
Access URL: https://doaj.org/article/f1d3d7fa0f1641e9a2625b9c001627c4
https://doaj.org/article/4c9858fc5c224fd6a7838f63df46aefc
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_911DDEE9C6EF5
https://serval.unil.ch/notice/serval:BIB_911DDEE9C6EF
https://serval.unil.ch/resource/serval:BIB_911DDEE9C6EF.P001/REF.pdf
Rights: CC BY
URL: http://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Accession Number: edsair.doi.dedup.....44d67d1a0d659d9d0d8861ab978b2c03
Database: OpenAIRE
Description
Abstract:Background Trace elements (TEs) status alterations in the brain have been linked to neurodegenerative diseases. However, data on TEs in living humans and in the post-traumatic conditions are scarce. Some TEs (copper – Cu, selenium – Se, zinc – Zn) are involved in essential antioxidant defence. This study aims to measure the evolution of TEs concentrations in the brain and serum of severe traumatic brain injury (TBI) patients over time. Methods Twenty adult patients with severe TBI were monitored using cerebral microdialysis (CMD) and blood sampling within three days of intensive care unit admission. TEs levels were measured using inductively coupled plasma system coupled to mass spectrometry. Results TEs concentrations of chromium – Cr, Cu, cobalt – Co, manganese – Mn, molybdenum – Mo, Se, and Zn were quantified in brain interstitial fluid and serum. While serum and CMD levels did not differ significantly for Co, Mo and Mn, and modest differences was observed for Cr and Zn, significant differences were observed for Cu and Se with higher serum levels (8–10-fold higher) compared to CMD. No correlation was found between serum and brain TEs levels, except for Mo. Conclusion This study provides novel TEs concentration data in living TBI patients, the largest differences between brain and serum being observed for Cu and Se, serving as a basis for further research on TEs dynamics in acute brain injury.
ISSN:19326203
DOI:10.1371/journal.pone.0326023