Frailty is associated with in-hospital mortality in older hospitalised COVID-19 patients in the Netherlands: the COVID-OLD study: the COVID-OLD study
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| Názov: | Frailty is associated with in-hospital mortality in older hospitalised COVID-19 patients in the Netherlands: the COVID-OLD study: the COVID-OLD study |
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| Autori: | Blomaard, L.C., Linden, C.M.J. van der, Bol, J.M. van der, Jansen, S.W.M., Polinder-Bos, H.A., Willems, H.C., Festen, J., Barten, D.G., Borgers, A.J., Bos, J.C., Bos, F. van den, Brouwer, E.J.M. de, Deudekom, F.J.A. van, Dijk, S.C. van, Emmelot-Vonk, M.H., Geels, R.E.S., Glind, E.M.M. van de, Groot, B. de, Hempenius, L., Kamper, A.M., Kampschreur, L.M., Koning, M.M.M. de, Labots, G., Looman, R., Lucke, J.A., Maas, H.A.A.M., Mattace-Raso, F.U.S., Moussaoui, R. el, Munster, B.C. van, Nieuwkoop, K. van, Oosterwijk, L.B., Regtuijt, M.E., Robben, S.H.M., Ruiter, R., Salarbaks, A.M., Schouten, H.J., Smit, O.M., Smits, R.A.L., Spies, P.E., Vreeswijk, R., Vries, O.J. de, Wijngaarden, M.A., Wyers, C.E., Mooijaart, S.P. |
| Prispievatelia: | MS Geriatrie, Cancer, Circulatory Health |
| Zdroj: | Age Ageing Age and Ageing |
| Informácie o vydavateľovi: | Oxford University Press (OUP), 2021. |
| Rok vydania: | 2021 |
| Predmety: | Male, Frail Elderly/statistics & numerical data, Frail Elderly, SCREENING TOOL, Netherlands/epidemiology, frailty, clinical frailty scale, Pandemics/statistics & numerical data, 03 medical and health sciences, 0302 clinical medicine, Journal Article, Humans, Hospital Mortality, Pandemics, older adults, Hospitalization/statistics & numerical data, Aged, Netherlands, Retrospective Studies, Aged, 80 and over, COVID-19/mortality, Frailty, SARS-CoV-2, COVID-19, General Medicine, INPATIENTS, MALNUTRITION, 3. Good health, Hospitalization, Ageing, Frailty/complications, Female, Geriatrics and Gerontology, Research Paper |
| Popis: | Background During the first wave of the coronavirus disease 2019 (COVID-19) pandemic, older patients had an increased risk of hospitalisation and death. Reports on the association of frailty with poor outcome have been conflicting. Objective The aim of the present study was to investigate the independent association between frailty and in-hospital mortality in older hospitalised COVID-19 patients in the Netherlands. Methods This was a multicentre retrospective cohort study in 15 hospitals in the Netherlands, including all patients aged ≥70 years, who were hospitalised with clinically confirmed COVID-19 between February and May 2020. Data were collected on demographics, co-morbidity, disease severity and Clinical Frailty Scale (CFS). Primary outcome was in-hospital mortality. Results A total of 1,376 patients were included (median age 78 years (interquartile range 74–84), 60% male). In total, 499 (38%) patients died during hospital admission. Parameters indicating presence of frailty (CFS 6–9) were associated with more co-morbidities, shorter symptom duration upon presentation (median 4 versus 7 days), lower oxygen demand and lower levels of C-reactive protein. In multivariable analyses, the CFS was independently associated with in-hospital mortality: compared with patients with CFS 1–3, patients with CFS 4–5 had a two times higher risk (odds ratio (OR) 2.0 (95% confidence interval (CI) 1.3–3.0)) and patients with CFS 6–9 had a three times higher risk of in-hospital mortality (OR 2.8 (95% CI 1.8–4.3)). Conclusions The in-hospital mortality of older hospitalised COVID-19 patients in the Netherlands was 38%. Frailty was independently associated with higher in-hospital mortality, even though COVID-19 patients with frailty presented earlier to the hospital with less severe symptoms. |
| Druh dokumentu: | Article Other literature type |
| Popis súboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1468-2834 0002-0729 |
| DOI: | 10.1093/ageing/afab018 |
| Prístupová URL adresa: | https://academic.oup.com/ageing/article-pdf/50/3/631/40968456/afab018.pdf https://pubmed.ncbi.nlm.nih.gov/33951156 https://pure.eur.nl/en/publications/6a0068cc-95fa-439a-a18f-b4b3ae315677 https://doi.org/10.1093/ageing/afab018 https://hdl.handle.net/11370/02f93cb1-ec00-4b78-8ac4-3df17cf3540c https://doi.org/10.1093/ageing/afab018 https://research.rug.nl/en/publications/02f93cb1-ec00-4b78-8ac4-3df17cf3540c https://pubmed.ncbi.nlm.nih.gov/33951156/ https://academic.oup.com/ageing/article/50/3/631/6123578 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7929372 https://www.narcis.nl/publication/RecordID/oai%3Apure.rug.nl%3Apublications%2F02f93cb1-ec00-4b78-8ac4-3df17cf3540c https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-1054261 https://research.rug.nl/en/publications/frailty-is-associated-with-in-hospital-mortality-in-older-hospita https://dspace.library.uu.nl/handle/1874/443067 https://hdl.handle.net/1887/3279529 https://pure.amsterdamumc.nl/en/publications/ae15dce6-5327-4b3d-aa4c-dd0f2def3d25 https://doi.org/10.1093/ageing/afab018 |
| Rights: | CC BY NC URL: http://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| Prístupové číslo: | edsair.doi.dedup.....4321a40d9167d6bef00eb1569f6447c4 |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Background During the first wave of the coronavirus disease 2019 (COVID-19) pandemic, older patients had an increased risk of hospitalisation and death. Reports on the association of frailty with poor outcome have been conflicting. Objective The aim of the present study was to investigate the independent association between frailty and in-hospital mortality in older hospitalised COVID-19 patients in the Netherlands. Methods This was a multicentre retrospective cohort study in 15 hospitals in the Netherlands, including all patients aged ≥70 years, who were hospitalised with clinically confirmed COVID-19 between February and May 2020. Data were collected on demographics, co-morbidity, disease severity and Clinical Frailty Scale (CFS). Primary outcome was in-hospital mortality. Results A total of 1,376 patients were included (median age 78 years (interquartile range 74–84), 60% male). In total, 499 (38%) patients died during hospital admission. Parameters indicating presence of frailty (CFS 6–9) were associated with more co-morbidities, shorter symptom duration upon presentation (median 4 versus 7 days), lower oxygen demand and lower levels of C-reactive protein. In multivariable analyses, the CFS was independently associated with in-hospital mortality: compared with patients with CFS 1–3, patients with CFS 4–5 had a two times higher risk (odds ratio (OR) 2.0 (95% confidence interval (CI) 1.3–3.0)) and patients with CFS 6–9 had a three times higher risk of in-hospital mortality (OR 2.8 (95% CI 1.8–4.3)). Conclusions The in-hospital mortality of older hospitalised COVID-19 patients in the Netherlands was 38%. Frailty was independently associated with higher in-hospital mortality, even though COVID-19 patients with frailty presented earlier to the hospital with less severe symptoms. |
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| ISSN: | 14682834 00020729 |
| DOI: | 10.1093/ageing/afab018 |