Cytological detection of copper for the diagnosis of inherited copper toxicosis in Bedlington terriers
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| Název: | Cytological detection of copper for the diagnosis of inherited copper toxicosis in Bedlington terriers |
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| Autoři: | Jan Rothuizen, Erik Teske, T.S.G.A.M. van den Ingh, Peter Bode, BG Brinkhuis |
| Zdroj: | Veterinary Record. 131:30-32 |
| Informace o vydavateli: | Wiley, 1992. |
| Rok vydání: | 1992 |
| Témata: | Dog Diseases/diagnosis, Liver Diseases/diagnosis, Staining and Labeling, Biopsy, Liver Diseases, Biopsy, Needle, 0402 animal and dairy science, 04 agricultural and veterinary sciences, Sensitivity and Specificity, Needle/veterinary, Thioamides, 0403 veterinary science, Dogs, Copper/poisoning, Animals, Indicators and Reagents, Dog Diseases, Staining and Labeling/veterinary, Copper |
| Popis: | The reliability of a cytological examination of impression smears of the liver was investigated in 89 Bedlington terriers by using the rubeanic acid staining method for copper and comparing the results with the results of a histological examination. Histological examination revealed copper accumulation in the liver of 24 dogs. The cytological method had a sensitivity of 0.96 for detecting copper toxicosis and a specificity of 1.0. When a grading system for the amount of copper was applied, the coefficient of correlation (r) between the cytological and histological techniques was 0.917 (P less than 0.0001). It was concluded that a cytological examination of impression smears stained with rubeanic acid for copper offers a rapid and reliable method for the detection of copper toxicosis in Bedlington terriers. |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 2042-7670 0042-4900 |
| DOI: | 10.1136/vr.131.2.30 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/1380748 https://research-portal.uu.nl/en/publications/60c03b87-cd1f-4573-91e7-d8f519bf2fbd https://www.ncbi.nlm.nih.gov/pubmed/1380748 |
| Přístupové číslo: | edsair.doi.dedup.....420539130c19c1c55ab5b522226819e2 |
| Databáze: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstrakt: | The reliability of a cytological examination of impression smears of the liver was investigated in 89 Bedlington terriers by using the rubeanic acid staining method for copper and comparing the results with the results of a histological examination. Histological examination revealed copper accumulation in the liver of 24 dogs. The cytological method had a sensitivity of 0.96 for detecting copper toxicosis and a specificity of 1.0. When a grading system for the amount of copper was applied, the coefficient of correlation (r) between the cytological and histological techniques was 0.917 (P less than 0.0001). It was concluded that a cytological examination of impression smears stained with rubeanic acid for copper offers a rapid and reliable method for the detection of copper toxicosis in Bedlington terriers. |
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| ISSN: | 20427670 00424900 |
| DOI: | 10.1136/vr.131.2.30 |