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Correlation of preoperative sonographic staging and postoperative histopathologic staging in patients with invasive breast cancer

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Titel: Correlation of preoperative sonographic staging and postoperative histopathologic staging in patients with invasive breast cancer
Autoren: Carolin Mueller, Julia Sarah Maria Zimmermann, Marc Philipp Radosa, Anna Katharina Hahn, Askin Canguel Kaya, Sarah Huwer, Lisa Stotz, Gudrun Wagenpfeil, Christoph Georg Radosa, Erich-Franz Solomayer, Julia Caroline Radosa
Quelle: Arch Gynecol Obstet
Verlagsinformationen: Springer Science and Business Media LLC, 2024.
Publikationsjahr: 2024
Schlagwörter: Adult, Aged, 80 and over, HER2 positive, ddc:610, Breast Neoplasms, Gynecologic Oncology, Middle Aged, Breast cancer diagnostics, Breast Neoplasms/diagnostic imaging [MeSH], Female [MeSH], Aged, 80 and over [MeSH], Preoperative Care [MeSH], Aged [MeSH], Adult [MeSH], Accuracy, Humans [MeSH], Breast cancer, Retrospective Studies [MeSH], Middle Aged [MeSH], Neoplasm Invasiveness [MeSH], Neoplasm Staging [MeSH], Sonography, Preoperative Period [MeSH], Breast Neoplasms/surgery [MeSH], Breast Neoplasms/pathology [MeSH], Breast imaging, Ultrasonography, Mammary [MeSH], Preoperative Care, Preoperative Period, Humans, Female, Neoplasm Invasiveness, Ultrasonography, Mammary, Neoplasm Staging, Aged, Retrospective Studies
Beschreibung: Purpose To assess the accuracy of preoperative sonographic staging in patients with primary invasive breast cancer. Methods We retrospectively analyzed a prospectively kept service database of patients with newly diagnosed, unifocal, cT1-3, invasive breast cancer. All patients were diagnosed at a single center institution between January 2013 and December 2021. Clinical T stage was assessed preoperatively by ultrasound and correlated with the definite postoperative pathologic T stage. Demographics, clinical and pathological characteristics were collected. Factors influencing accuracy, over- and underdiagnosis of sonographic staging were analyzed with multivariable regression analysis. Results A total of 2478 patients were included in the analysis. Median patients’ age was 65 years. 1577 patients (63.6%) had clinical T1 stage, 864 (34.9%) T2 and 37 (1.5%) T3 stage. The overall accuracy of sonography and histology was 76.5% (n = 1896), overestimation was observed in 9.1% (n = 225) of all cases, while underestimation occurred in 14.4% (n = 357) of all cases. Accuracy increased when clinical tumor stage cT was higher (OR 1.23; 95% CI 1.10–1.38, p ≤ 0.001). The highest accuracy was seen for patients with T2 stage (82.8%). The accuracy was lower in Luminal B tumors compared to Luminal A tumors (OR 0.71; 95% CI 0.59–0.87, p ≤ 0.001). We could not find any association between sonographic accuracy in HER2 positive patients, and demographic characteristics, or tumor-related factors. Conclusion Our unicentric study showed a high accuracy of sonography in predicting T stage, especially for tumors with clinical T2 stage. Tumor stage and biological tumor factors do affect the accuracy of sonographic staging.
Publikationsart: Article
Other literature type
Dateibeschreibung: pdf
Sprache: English
ISSN: 1432-0711
DOI: 10.1007/s00404-024-07699-5
DOI: 10.22028/d291-43602
Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39222087
https://repository.publisso.de/resource/frl:6521157
Rights: CC BY
Dokumentencode: edsair.doi.dedup.....41756f5ebf2a2a450a726ab1a958e2ae
Datenbank: OpenAIRE
Beschreibung
Abstract:Purpose To assess the accuracy of preoperative sonographic staging in patients with primary invasive breast cancer. Methods We retrospectively analyzed a prospectively kept service database of patients with newly diagnosed, unifocal, cT1-3, invasive breast cancer. All patients were diagnosed at a single center institution between January 2013 and December 2021. Clinical T stage was assessed preoperatively by ultrasound and correlated with the definite postoperative pathologic T stage. Demographics, clinical and pathological characteristics were collected. Factors influencing accuracy, over- and underdiagnosis of sonographic staging were analyzed with multivariable regression analysis. Results A total of 2478 patients were included in the analysis. Median patients’ age was 65 years. 1577 patients (63.6%) had clinical T1 stage, 864 (34.9%) T2 and 37 (1.5%) T3 stage. The overall accuracy of sonography and histology was 76.5% (n = 1896), overestimation was observed in 9.1% (n = 225) of all cases, while underestimation occurred in 14.4% (n = 357) of all cases. Accuracy increased when clinical tumor stage cT was higher (OR 1.23; 95% CI 1.10–1.38, p ≤ 0.001). The highest accuracy was seen for patients with T2 stage (82.8%). The accuracy was lower in Luminal B tumors compared to Luminal A tumors (OR 0.71; 95% CI 0.59–0.87, p ≤ 0.001). We could not find any association between sonographic accuracy in HER2 positive patients, and demographic characteristics, or tumor-related factors. Conclusion Our unicentric study showed a high accuracy of sonography in predicting T stage, especially for tumors with clinical T2 stage. Tumor stage and biological tumor factors do affect the accuracy of sonographic staging.
ISSN:14320711
DOI:10.1007/s00404-024-07699-5