Noninvasive evaluation of pulmonary artery stiffness in heart failure patients via cardiovascular magnetic resonance
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| Název: | Noninvasive evaluation of pulmonary artery stiffness in heart failure patients via cardiovascular magnetic resonance |
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| Autoři: | Hou, Xuewen, Hashemi, Djawid, Erley, Jennifer, Neye, Marthe, Bucius, Paulius, Tanacli, Radu, Kühne, Titus, Kelm, Marcus, Motzkus, Laura, Blum, Moritz, Edelmann, Frank, Kuebler, Wolfgang M., Pieske, Burkert, Düngen, Hans-Dirk, Schuster, Andreas, Stoiber, Lukas, Kelle, Sebastian |
| Přispěvatelé: | Hou, Xuewen, Hashemi, Djawid, Erley, Jennifer, Neye, Marthe, Bucius, Paulius, Tanacli, Radu, Kühne, Titus, Kelm, Marcus, Motzkus, Laura, Blum, Moritz, Kelle, Sebastian |
| Zdroj: | Sci Rep Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023) |
| Informace o vydavateli: | Springer Science and Business Media LLC, 2023. |
| Rok vydání: | 2023 |
| Témata: | Adult, Heart Failure, Magnetic Resonance Spectroscopy, Medizin und Gesundheit, Science, Pulmonary Artery / diagnostic imaging, Stroke Volume, Pulmonary Artery, Pulse Wave Analysis, Prognosis, Article, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Medicine, Humans |
| Popis: | Heart failure (HF) presents manifestations in both cardiac and vascular abnormalities. Pulmonary hypertension (PH) is prevalent in up 50% of HF patients. While pulmonary arterial hypertension (PAH) is closely associated with pulmonary artery (PA) stiffness, the association of HF caused, post-capillary PH and PA stiffness is unknown. We aimed to assess and compare PA stiffness and blood flow hemodynamics noninvasively across HF entities and control subjects without HF using CMR. We analyzed data of a prospectively conducted study with 74 adults, including 55 patients with HF across the spectrum (20 HF with preserved ejection fraction [HFpEF], 18 HF with mildly-reduced ejection fraction [HFmrEF] and 17 HF with reduced ejection fraction [HFrEF]) as well as 19 control subjects without HF. PA stiffness was defined as reduced vascular compliance, indicated primarily by the relative area change (RAC), altered flow hemodynamics were detected by increased flow velocities, mainly by pulse wave velocity (PWV). Correlations between the variables were explored using correlation and linear regression analysis. PA stiffness was significantly increased in HF patients compared to controls (RAC 30.92 ± 8.47 vs. 50.08 ± 9.08%, p Trial registration The study was registered at the German Clinical Trials Register (DRKS, registration number: DRKS00015615). |
| Druh dokumentu: | Article Other literature type |
| Jazyk: | English |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-023-49325-5 |
| DOI: | 10.17169/refubium-49023 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/38114509 https://doaj.org/article/ef2ae5a721e34cbca4be2f658c8d2ab4 https://resolver.sub.uni-goettingen.de/purl?gro-2/139717 |
| Rights: | CC BY |
| Přístupové číslo: | edsair.doi.dedup.....41465a833d17e5c65d4b523c3eb63780 |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Heart failure (HF) presents manifestations in both cardiac and vascular abnormalities. Pulmonary hypertension (PH) is prevalent in up 50% of HF patients. While pulmonary arterial hypertension (PAH) is closely associated with pulmonary artery (PA) stiffness, the association of HF caused, post-capillary PH and PA stiffness is unknown. We aimed to assess and compare PA stiffness and blood flow hemodynamics noninvasively across HF entities and control subjects without HF using CMR. We analyzed data of a prospectively conducted study with 74 adults, including 55 patients with HF across the spectrum (20 HF with preserved ejection fraction [HFpEF], 18 HF with mildly-reduced ejection fraction [HFmrEF] and 17 HF with reduced ejection fraction [HFrEF]) as well as 19 control subjects without HF. PA stiffness was defined as reduced vascular compliance, indicated primarily by the relative area change (RAC), altered flow hemodynamics were detected by increased flow velocities, mainly by pulse wave velocity (PWV). Correlations between the variables were explored using correlation and linear regression analysis. PA stiffness was significantly increased in HF patients compared to controls (RAC 30.92 ± 8.47 vs. 50.08 ± 9.08%, p Trial registration The study was registered at the German Clinical Trials Register (DRKS, registration number: DRKS00015615). |
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| ISSN: | 20452322 |
| DOI: | 10.1038/s41598-023-49325-5 |