The in-vitro antimicrobial activity of some medicinal plants against β-lactam-resistant bacteria
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| Titel: | The in-vitro antimicrobial activity of some medicinal plants against β-lactam-resistant bacteria |
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| Autoren: | Gangoue Pieboji, Joseph, Eze, N., Ngongang Djintchui, A., Ngameni, B., Tsabang, N., Pegnyemb, D. E., Biyiti, L., Ngassam, P., Koulla-Shiro, S., Galleni, Moreno |
| Quelle: | Journal of Infection in Developing Countries, Vol 3, Iss 09 (2009) |
| Verlagsinformationen: | Journal of Infection in Developing Countries, 2009. |
| Publikationsjahr: | 2009 |
| Schlagwörter: | β-lactam-resistant bacteria, 0301 basic medicine, Microbial Sensitivity Tests, Plant Bark/chemistry, Biochimie, biophysique & biologie moléculaire, Microbiology, 01 natural sciences, beta-Lactam Resistance, 03 medical and health sciences, Plants, Medicinal/*chemistry, Cameroon, Anti-Bacterial Agents/isolation & purification/*pharmacology, Internal medicine, Plant Stems/chemistry, antimicrobial activity, Plants, Medicinal, Bacteria, Plant Stems, Plant Extracts, Medicinal plant, Bacteria/*drug effects, Plant Leaves/chemistry, 15. Life on land, β-lactamase, Life sciences, RC31-1245, QR1-502, Anti-Bacterial Agents, 3. Good health, 0104 chemical sciences, Plant Leaves, Sciences du vivant, Plant Bark, Microbial Sensitivity Tests/methods, Plant Extracts/isolation & purification/*pharmacology, Biochemistry, biophysics & molecular biology |
| Beschreibung: | Background: In effort to identify novel bacterial agents, this study was initiated to evaluate the antimicrobial properties of 17 crude extracts from 12 medicinal plants against beta-lactam-resistant bacteria. Methodology: The antimicrobial activities of plant extracts were evaluated against clinically proved beta-lactam-resistant bacteria (Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, Serratia marcescens, Acinetobacter baumannii, Staphylococcus aureus and Enterococcus sp.) and reference strains of bacteria (Escherichia coli ATCC 35218, Enterobacter aerogenes ATCC 29751, E. aerogenes ATCC 13048, Pseudomonas aeruginosa ATCC 27853 and Enterococcus hirae ATCC 9790) by using disc-diffusion and agar-dilution assays. Results: The crude plant extracts demonstrated broad spectrum activity against all bacteria tested with inhibition zones in the range of 8-30 mm. The minimal inhibitory concentration (MIC) values of different plant extracts against the tested bacteria were found to range from ≤ 0.3 to ≥ 10 mg ml-1. The most active plant extracts were from Dortenia picta and Bridelia micrantha (MIC: 1.25-10 mg ml-1) on beta-lactam-resistant Gram-negative bacilli and the extracts from B. micrantha, Mallotus oppositifolius, Garcinia lucida, Garcinia. kola, Campylospermum densiflorum (leaves) and C. zenkeri (root) on beta-lactam-resistant Gram-positive cocci (MIC: ≤ 0.3-5 mg ml-1). Conclusion: Of the 17 plant extracts studied, seven showed good antimicrobial activity against the tested bacteria. The stem bark of B. micrantha and the leaves of D. picta were most active towards beta-lactamase producing Gram-negative bacilli. This study shows that medicinal plants could be sources of compounds which can be used to fight against beta-lactam resistant bacteria. |
| Publikationsart: | Article |
| ISSN: | 1972-2680 |
| DOI: | 10.3855/jidc.77 |
| Zugangs-URL: | https://jidc.org/index.php/journal/article/download/19858568/300 https://pubmed.ncbi.nlm.nih.gov/19858568 https://doaj.org/article/e006bfcdac5d45aa98b0773504f0eae5 https://orbi.uliege.be/handle/2268/62988 https://pubmed.ncbi.nlm.nih.gov/19858568/ https://www.ncbi.nlm.nih.gov/pubmed/19858568 https://www.cabdirect.org/cabdirect/abstract/20093329123 https://europepmc.org/article/MED/19858568 |
| Rights: | CC BY |
| Dokumentencode: | edsair.doi.dedup.....40f9665dc6d79b5a6fb2f52727888f21 |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Background: In effort to identify novel bacterial agents, this study was initiated to evaluate the antimicrobial properties of 17 crude extracts from 12 medicinal plants against beta-lactam-resistant bacteria. Methodology: The antimicrobial activities of plant extracts were evaluated against clinically proved beta-lactam-resistant bacteria (Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, Serratia marcescens, Acinetobacter baumannii, Staphylococcus aureus and Enterococcus sp.) and reference strains of bacteria (Escherichia coli ATCC 35218, Enterobacter aerogenes ATCC 29751, E. aerogenes ATCC 13048, Pseudomonas aeruginosa ATCC 27853 and Enterococcus hirae ATCC 9790) by using disc-diffusion and agar-dilution assays. Results: The crude plant extracts demonstrated broad spectrum activity against all bacteria tested with inhibition zones in the range of 8-30 mm. The minimal inhibitory concentration (MIC) values of different plant extracts against the tested bacteria were found to range from ≤ 0.3 to ≥ 10 mg ml-1. The most active plant extracts were from Dortenia picta and Bridelia micrantha (MIC: 1.25-10 mg ml-1) on beta-lactam-resistant Gram-negative bacilli and the extracts from B. micrantha, Mallotus oppositifolius, Garcinia lucida, Garcinia. kola, Campylospermum densiflorum (leaves) and C. zenkeri (root) on beta-lactam-resistant Gram-positive cocci (MIC: ≤ 0.3-5 mg ml-1). Conclusion: Of the 17 plant extracts studied, seven showed good antimicrobial activity against the tested bacteria. The stem bark of B. micrantha and the leaves of D. picta were most active towards beta-lactamase producing Gram-negative bacilli. This study shows that medicinal plants could be sources of compounds which can be used to fight against beta-lactam resistant bacteria. |
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| ISSN: | 19722680 |
| DOI: | 10.3855/jidc.77 |