Interactions between physical exercise, associative memory, and genetic risk for Alzheimer’s disease
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| Titel: | Interactions between physical exercise, associative memory, and genetic risk for Alzheimer’s disease |
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| Autoren: | Igloi, Kinga Katinka, Marin Bosch, Blanca, Kuenzi, Noémie, Thomas, Aurélien, Lauer, Estelle, Bringard, Aurélien, Schwartz, Sophie |
| Quelle: | Cereb Cortex Cerebral cortex, vol. 34, no. 5 |
| Verlagsinformationen: | Oxford University Press (OUP), 2024. |
| Publikationsjahr: | 2024 |
| Schlagwörter: | Humans, Alzheimer Disease/genetics, Alzheimer Disease/physiopathology, Alzheimer Disease/diagnostic imaging, Male, Female, Exercise/physiology, Magnetic Resonance Imaging, Adult, Young Adult, Memory/physiology, Endocannabinoids/genetics, Genetic Predisposition to Disease, Association Learning/physiology, Apolipoprotein E4/genetics, Hippocampus/diagnostic imaging, Hippocampus/physiology, Brain/diagnostic imaging, Brain/physiology, Heterozygote, Alzheimer's disease, endocannabinoids, fMRI, memory, physical exercise, 616.8, Hippocampus / diagnostic imaging, Brain / diagnostic imaging, Apolipoprotein E4, 128.37, Apolipoprotein E4 / genetics, 614.1, Hippocampus / physiology, Hippocampus, Alzheimer Disease, Memory, Memory / physiology, Alzheimer Disease / physiopathology, Exercise, Endocannabinoids / genetics, Association Learning / physiology, Exercise / physiology, Physical exercise, Association Learning, Brain, 3. Good health, Alzheimer Disease / genetics, FMRI, Brain / physiology, Original Article, Alzheimer Disease / diagnostic imaging, Endocannabinoids |
| Beschreibung: | The ε4 allele of the APOE gene heightens the risk of late onset Alzheimer’s disease. ε4 carriers, may exhibit cognitive and neural changes early on. Given the known memory-enhancing effects of physical exercise, particularly through hippocampal plasticity via endocannabinoid signaling, here we aimed to test whether a single session of physical exercise may benefit memory and underlying neurophysiological processes in young ε3 carriers (ε3/ε4 heterozygotes, risk group) compared with a matched control group (homozygotes for ε3). Participants underwent fMRI while learning picture sequences, followed by cycling or rest before a memory test. Blood samples measured endocannabinoid levels. At the behavioral level, the risk group exhibited poorer associative memory performance, regardless of the exercising condition. At the brain level, the risk group showed increased medial temporal lobe activity during memory retrieval irrespective of exercise (suggesting neural compensatory effects even at baseline), whereas, in the control group, such increase was only detectable after physical exercise. Critically, an exercise-related endocannabinoid increase correlated with task-related hippocampal activation in the control group only. In conclusion, healthy young individuals carrying the ε4 allele may present suboptimal associative memory performance (when compared with homozygote ε3 carriers), together with reduced plasticity (and functional over-compensation) within medial temporal structures. |
| Publikationsart: | Article Other literature type |
| Dateibeschreibung: | application/pdf |
| Sprache: | English |
| ISSN: | 1460-2199 1047-3211 |
| DOI: | 10.1093/cercor/bhae205 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/38802684 https://archive-ouverte.unige.ch/unige:186967 https://doi.org/10.1093/cercor/bhae205 https://serval.unil.ch/notice/serval:BIB_EC2404FC71AD http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_EC2404FC71AD1 https://serval.unil.ch/resource/serval:BIB_EC2404FC71AD.P001/REF.pdf |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Dokumentencode: | edsair.doi.dedup.....40dc684046623d7d1f42edf67b78fd4f |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | The ε4 allele of the APOE gene heightens the risk of late onset Alzheimer’s disease. ε4 carriers, may exhibit cognitive and neural changes early on. Given the known memory-enhancing effects of physical exercise, particularly through hippocampal plasticity via endocannabinoid signaling, here we aimed to test whether a single session of physical exercise may benefit memory and underlying neurophysiological processes in young ε3 carriers (ε3/ε4 heterozygotes, risk group) compared with a matched control group (homozygotes for ε3). Participants underwent fMRI while learning picture sequences, followed by cycling or rest before a memory test. Blood samples measured endocannabinoid levels. At the behavioral level, the risk group exhibited poorer associative memory performance, regardless of the exercising condition. At the brain level, the risk group showed increased medial temporal lobe activity during memory retrieval irrespective of exercise (suggesting neural compensatory effects even at baseline), whereas, in the control group, such increase was only detectable after physical exercise. Critically, an exercise-related endocannabinoid increase correlated with task-related hippocampal activation in the control group only. In conclusion, healthy young individuals carrying the ε4 allele may present suboptimal associative memory performance (when compared with homozygote ε3 carriers), together with reduced plasticity (and functional over-compensation) within medial temporal structures. |
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| ISSN: | 14602199 10473211 |
| DOI: | 10.1093/cercor/bhae205 |