The fracture predictive ability of lumbar spine BMD and TBS as calculated based on different combinations of the lumbar spine vertebrae
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| Názov: | The fracture predictive ability of lumbar spine BMD and TBS as calculated based on different combinations of the lumbar spine vertebrae |
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| Autori: | Shevroja, E., Mo Costabella, F., Gonzalez Rodriguez, E., Lamy, O., Hans, D. |
| Zdroj: | Arch Osteoporos Archives of osteoporosis, vol. 17, no. 1, pp. 83 |
| Informácie o vydavateľovi: | Springer Science and Business Media LLC, 2022. |
| Rok vydania: | 2022 |
| Predmety: | 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, Absorptiometry, Photon, Lumbar Vertebrae, Bone Density, Cancellous Bone, Humans, Original Article, Female, Absorptiometry, Photon/methods, Cancellous Bone/diagnostic imaging, Lumbar Vertebrae/diagnostic imaging, Osteoporotic Fractures/diagnostic imaging, Bone mineral density, DXA, Fracture risk assessment, Osteoporosis, Trabecular bone score, Osteoporotic Fractures |
| Popis: | Summary Lumbar spine bone mineral density (BMD) and trabecular bone score (TBS) are both calculated on L1-L4 vertebrae. This study investigated the ability to predict osteoporotic fractures of BMD and TBS as calculated based on all possible adjacent L1-L4 vertebrae combinations. Present findings indicate that L1-L3 is an optimal combination to calculate LS-BMD or TBS. Introduction Lumbar spine (LS) BMD and TBS are both assessed in the LS DXA scans in the same region of interest, L1-L4. We aimed to investigate the ability to predict osteoporotic fractures of all the possible adjacent LS vertebrae combinations used to calculate BMD and TBS and to evaluate if any of these combinations performs better at osteoporotic fracture prediction than the traditional L1-L4 combination. Methods This study was embedded in OsteoLaus-women cohort in Switzerland. LS-DXA scans were performed using Discovery A System (Hologic). The incident vertebral fractures (VFs) and major osteoporotic fractures (MOFs) were assessed from VF assessments using Genant’s method or questionnaires (non-VF MOF). We ran logistic models using TBS and BMD to predict MOF, VF, and non-VF MOF, combining different adjustment factors (age, fracture level, or BMD). Results One thousand six hundred thirty-two women (mean ± SD) 64.4 ± 7.5 years, BMI 25.9 ± 4.5 kg/m2, were followed for 4.4 years and 133 experienced MOF. The association of one SD decrease L1-L3 BMD with the odds ratios (ORs) of MOF was OR 1.32 (95%CI 1.15–1.53), L2-L4 BMD was 1.25 (95%CI 1.09–1.42), and L1-L4 BMD was 1.30 (95%CI 1.14–1.48). One SD decrease in L1-L3 TBS was more strongly associated with the odds of having a MOF (OR 1.64, 95% CI 1.34–2.00), than one SD decrease in L2-L4 TBS (OR 1.48, 95% CI 1.21–1.81), or in L1-L4 TBS (OR 1.60, CI 95% 1.32–1.95). Conclusion Current findings indicate that L1-L3 is an optimal combination for the TBS or LS-BMD calculation. |
| Druh dokumentu: | Article Other literature type |
| Popis súboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1862-3514 1862-3522 |
| DOI: | 10.1007/s11657-022-01123-8 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/35678937 https://serval.unil.ch/notice/serval:BIB_8219FD93EE7B https://serval.unil.ch/resource/serval:BIB_8219FD93EE7B.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_8219FD93EE7B3 |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) . |
| Prístupové číslo: | edsair.doi.dedup.....3fc8a9e37c399738eb93c42e5da1044e |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Summary Lumbar spine bone mineral density (BMD) and trabecular bone score (TBS) are both calculated on L1-L4 vertebrae. This study investigated the ability to predict osteoporotic fractures of BMD and TBS as calculated based on all possible adjacent L1-L4 vertebrae combinations. Present findings indicate that L1-L3 is an optimal combination to calculate LS-BMD or TBS. Introduction Lumbar spine (LS) BMD and TBS are both assessed in the LS DXA scans in the same region of interest, L1-L4. We aimed to investigate the ability to predict osteoporotic fractures of all the possible adjacent LS vertebrae combinations used to calculate BMD and TBS and to evaluate if any of these combinations performs better at osteoporotic fracture prediction than the traditional L1-L4 combination. Methods This study was embedded in OsteoLaus-women cohort in Switzerland. LS-DXA scans were performed using Discovery A System (Hologic). The incident vertebral fractures (VFs) and major osteoporotic fractures (MOFs) were assessed from VF assessments using Genant’s method or questionnaires (non-VF MOF). We ran logistic models using TBS and BMD to predict MOF, VF, and non-VF MOF, combining different adjustment factors (age, fracture level, or BMD). Results One thousand six hundred thirty-two women (mean ± SD) 64.4 ± 7.5 years, BMI 25.9 ± 4.5 kg/m2, were followed for 4.4 years and 133 experienced MOF. The association of one SD decrease L1-L3 BMD with the odds ratios (ORs) of MOF was OR 1.32 (95%CI 1.15–1.53), L2-L4 BMD was 1.25 (95%CI 1.09–1.42), and L1-L4 BMD was 1.30 (95%CI 1.14–1.48). One SD decrease in L1-L3 TBS was more strongly associated with the odds of having a MOF (OR 1.64, 95% CI 1.34–2.00), than one SD decrease in L2-L4 TBS (OR 1.48, 95% CI 1.21–1.81), or in L1-L4 TBS (OR 1.60, CI 95% 1.32–1.95). Conclusion Current findings indicate that L1-L3 is an optimal combination for the TBS or LS-BMD calculation. |
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| ISSN: | 18623514 18623522 |
| DOI: | 10.1007/s11657-022-01123-8 |