SNPs of Fc-gamma Receptor Genes and Chronic Periodontitis
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| Titel: | SNPs of Fc-gamma Receptor Genes and Chronic Periodontitis |
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| Autoren: | Wai K. Leung, L Chai, Kwan-Yat Zee, You-Qiang Song |
| Quelle: | Journal of Dental Research. 89:705-710 |
| Verlagsinformationen: | SAGE Publications, 2010. |
| Publikationsjahr: | 2010 |
| Schlagwörter: | Adult, Male, Guanine, Genotype, IgG, Receptors, IgG - genetics, 1105 Dentistry, Single-nucleotide, Polymorphism, Single Nucleotide, IgG - genetics, Cytosine, 03 medical and health sciences, C1, Sex Factors, 0302 clinical medicine, Receptors, Single Nucleotide - genetics, Humans, Polymorphism, Alleles, Chronic Periodontitis - genetics, Adenine, Receptors, IgG, Smoking, Age Factors, Middle Aged, Polymorphism, Single Nucleotide - genetics, 3. Good health, Haplotypes, Case-Control Studies, Chronic Periodontitis, Chronic periodontitis, Hong Kong, Female, Polymorphisms, Thymine |
| Beschreibung: | Genetic polymorphisms of host defense genes might increase risk for periodontitis. This case-control study investigated whether 102 single-nucleotide polymorphisms (SNPs) in Fc gamma receptor ( FCGR) genes are associated with chronic periodontitis. Cases were 190 Hong Kong Chinese patients with severe chronic periodontitis, and there were 169 periodontitis-free individuals as controls. Genotype CC and allele C of rs445509 ( p < 0.0001, OR = 0.30) of FCGR3A were significantly more prevalent among control individuals than among cases, after adjustment for age, sex, and smoking. Smoking was significantly associated with chronic periodontitis ( p = 0.003, OR = 3.35). Within the limitations of this study, SNP rs445509 of FCGR3A seem to be negatively associated, while smoking was positively associated, with severe chronic periodontitis among Hong Kong Chinese. |
| Publikationsart: | Article |
| Sprache: | English |
| ISSN: | 1544-0591 0022-0345 |
| DOI: | 10.1177/0022034510365444 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/20439936 http://journals.sagepub.com/doi/10.1177/0022034510365444 https://www.cabdirect.org/cabdirect/abstract/20103224913 http://europepmc.org/abstract/MED/20439936 http://hub.hku.hk/handle/10722/129103 https://www.ncbi.nlm.nih.gov/pubmed/20439936 https://espace.library.uq.edu.au/view/UQ:216845 http://hdl.handle.net/10722/129103 |
| Rights: | URL: https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| Dokumentencode: | edsair.doi.dedup.....3f7092b5a175d226faa11960859fdcf5 |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Genetic polymorphisms of host defense genes might increase risk for periodontitis. This case-control study investigated whether 102 single-nucleotide polymorphisms (SNPs) in Fc gamma receptor ( FCGR) genes are associated with chronic periodontitis. Cases were 190 Hong Kong Chinese patients with severe chronic periodontitis, and there were 169 periodontitis-free individuals as controls. Genotype CC and allele C of rs445509 ( p < 0.0001, OR = 0.30) of FCGR3A were significantly more prevalent among control individuals than among cases, after adjustment for age, sex, and smoking. Smoking was significantly associated with chronic periodontitis ( p = 0.003, OR = 3.35). Within the limitations of this study, SNP rs445509 of FCGR3A seem to be negatively associated, while smoking was positively associated, with severe chronic periodontitis among Hong Kong Chinese. |
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| ISSN: | 15440591 00220345 |
| DOI: | 10.1177/0022034510365444 |