Relationship between systolic blood pressure and renal function on clinical outcomes in patients with atrial fibrillation: a report from the prospective AF-GEN-UK Registry
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| Název: | Relationship between systolic blood pressure and renal function on clinical outcomes in patients with atrial fibrillation: a report from the prospective AF-GEN-UK Registry |
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| Autoři: | Shantsila, Alena, Lip, Gregory Y. H., Lane, Deirdre A. |
| Zdroj: | J Hypertens Shantsila, A, Lip, G Y H & Lane, D A 2024, 'Relationship between systolic blood pressure and renal function on clinical outcomes in patients with atrial fibrillation: a report from the prospective AF-GEN-UK Registry', Journal of Hypertension, vol. 42, no. 12, pp. 2148-2154. https://doi.org/10.1097/HJH.0000000000003856 |
| Informace o vydavateli: | Ovid Technologies (Wolters Kluwer Health), 2024. |
| Rok vydání: | 2024 |
| Témata: | Male, Aged, 80 and over, United Kingdom/epidemiology, renal function, blood pressure, Blood Pressure, Original Articles, prospective, Middle Aged, Kidney, Prognosis, mortality, Blood Pressure/drug effects, United Kingdom, Atrial Fibrillation/physiopathology, Atrial Fibrillation, Humans, atrial fibrillation, Female, Prospective Studies, Registries, Kidney/physiopathology, Aged, Glomerular Filtration Rate |
| Popis: | Background: Blood pressure (BP) extremes and renal (dys)function contribute to poor outcomes in patients with atrial fibrillation (AF). Using data from the prospective AF-GEN-UK study, we investigated the effect of systolic BP and interaction with renal function for prognostication. Methods: Baseline systolic BP (SBP) values were recorded for 1580 patients (mean [SD] age 71 [11] years, 60% male) and categorized as follows: 120–129 mmHg (n = 289, reference group) n = 165), 110–119 mmHg, (n = 254), 130–139 mmHg (n = 321), 140–159 mmHg (n = 385) and ≥160 mmHg (n = 166). Cox regression analysis, adjusted for age, oral anticoagulation (OAC) and CHA2DS2-VASc score established the impact of SBP, renal function and their interaction on 1-year outcomes. SBP groups were compared using ANOVA and chi-square tests. Results: OAC use was 84% and similar across SBP groups. Renal dysfunction [estimated baseline glomerular filtration rate (eGFR) < 60 ml/min] was present in 24%, with significantly lower eGFR values in the SBP 110–119 mmHg group. History of heart failure was significantly higher in those with SBP Conclusions: In people with AF, SBP |
| Druh dokumentu: | Article Other literature type |
| Popis souboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1473-5598 0263-6352 |
| DOI: | 10.1097/hjh.0000000000003856 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/39315543 https://vbn.aau.dk/ws/files/754668892/Shantsila_Lip_Lane_2024_._Relationship_between_systolic_blood_pressure_and_renal_function_on_clinical_outcomes_in_patients_with_atrial_fibrillation_-_a_report_from_the_prospective_AF-GEN-UK_Registry.pdf https://vbn.aau.dk/da/publications/d0c2ce7a-16b5-4d14-82a2-15b6f08afbe7 http://www.scopus.com/inward/record.url?scp=85208160707&partnerID=8YFLogxK https://doi.org/10.1097/HJH.0000000000003856 |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (http://creativecommons.org/licenses/by/4.0/) |
| Přístupové číslo: | edsair.doi.dedup.....3eb209ac2b56ae921fe684dda3128ed4 |
| Databáze: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstrakt: | Background: Blood pressure (BP) extremes and renal (dys)function contribute to poor outcomes in patients with atrial fibrillation (AF). Using data from the prospective AF-GEN-UK study, we investigated the effect of systolic BP and interaction with renal function for prognostication. Methods: Baseline systolic BP (SBP) values were recorded for 1580 patients (mean [SD] age 71 [11] years, 60% male) and categorized as follows: 120–129 mmHg (n = 289, reference group) n = 165), 110–119 mmHg, (n = 254), 130–139 mmHg (n = 321), 140–159 mmHg (n = 385) and ≥160 mmHg (n = 166). Cox regression analysis, adjusted for age, oral anticoagulation (OAC) and CHA2DS2-VASc score established the impact of SBP, renal function and their interaction on 1-year outcomes. SBP groups were compared using ANOVA and chi-square tests. Results: OAC use was 84% and similar across SBP groups. Renal dysfunction [estimated baseline glomerular filtration rate (eGFR) < 60 ml/min] was present in 24%, with significantly lower eGFR values in the SBP 110–119 mmHg group. History of heart failure was significantly higher in those with SBP Conclusions: In people with AF, SBP |
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| ISSN: | 14735598 02636352 |
| DOI: | 10.1097/hjh.0000000000003856 |