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TTF-1 is a highly sensitive but not fully specific marker for pulmonary and thyroidal cancer: a tissue microarray study evaluating more than 17,000 tumors from 152 different tumor entities

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Title: TTF-1 is a highly sensitive but not fully specific marker for pulmonary and thyroidal cancer: a tissue microarray study evaluating more than 17,000 tumors from 152 different tumor entities
Authors: Katharina Möller, Tayyaba Gulzar, Maximilian Lennartz, Florian Viehweger, Martina Kluth, Claudia Hube-Magg, Christian Bernreuther, Ahmed Abdulwahab Bawahab, Ronald Simon, Till S. Clauditz, Guido Sauter, Ria Schlichter, Andrea Hinsch, Simon Kind, Frank Jacobsen, Eike Burandt, Nikolaj Frost, Martin Reck, Andreas H. Marx, Till Krech, Patrick Lebok, Christoph Fraune, Stefan Steurer
Source: Virchows Arch
Publisher Information: Springer Science and Business Media LLC, 2024.
Publication Year: 2024
Subject Terms: Lung Neoplasms, Thyroid Nuclear Factor 1, Nuclear Proteins, Adenocarcinoma, Sensitivity and Specificity, Immunohistochemistry, Tissue Array Analysis, Transcription Factors/analysis [MeSH], Lung Neoplasms/diagnosis [MeSH], TTF-1, Aspartic Acid Endopeptidases [MeSH], Tissue Array Analysis [MeSH], Tissue microarray, Adenocarcinoma/metabolism [MeSH], Original Article, Nuclear Proteins/metabolism [MeSH], Sensitivity and Specificity [MeSH], Thyroid Neoplasms/metabolism [MeSH], Adenocarcinoma/pathology [MeSH], Diagnosis, Transcription Factors/metabolism [MeSH], Biomarkers, Tumor/analysis [MeSH], Nuclear Proteins/analysis [MeSH], Thyroid Neoplasms/diagnosis [MeSH], Thyroid Nuclear Factor 1/analysis [MeSH], Humans [MeSH], Pulmonary adenocarcinomas, Thyroid Neoplasms/pathology [MeSH], Immunohistochemistry [MeSH], Lung Neoplasms/pathology [MeSH], Adenocarcinoma/diagnosis [MeSH], Lung Neoplasms/metabolism [MeSH], Thyroid Nuclear Factor 1/metabolism [MeSH], Biomarkers, Tumor, Humans, Aspartic Acid Endopeptidases, Thyroid Neoplasms, Transcription Factors
Description: Thyroid transcription factor 1 (TTF-1) immunohistochemistry (IHC) is routinely used for the distinction of primary pulmonary adenocarcinomas. However, TTF-1 can also occur in other malignancies. A tissue microarray containing 17,772 samples from 152 different tumor types was analyzed. Napsin-A, CK20, SATB2, FABP1, and Villin-1 IHC data were available from previous studies. TTF-1 staining was seen in 82 of 152 tumor categories including thyroidal cancers (19–100%), adenocarcinomas (94%), neuroendocrine tumors (67%) of the lung, small cell neuroendocrine carcinomas (71–80%), mesenchymal tumors (up to 42%), and thymomas (39%). Comparative analysis of TTF-1 and Napsin-A revealed a sensitivity/specificity of 94%/86% (TTF-1), 87%/98% (Napsin-A), and 85%/99.1% (TTF-1 and Napsin-A) for the distinction of pulmonary adenocarcinomas. Combined analysis of TTF-1 and enteric markers revealed a positivity for TTF-1 and at least one enteric marker in 22% of pulmonary adenocarcinomas but also a TTF-1 positivity in 6% of colorectal, 2% of pancreatic, and 3% of gastric adenocarcinomas. TTF-1 is a marker of high sensitivity but insufficient specificity for pulmonary adenocarcinomas. A small fraction of TTF-1-positive gastrointestinal adenocarcinomas represents a pitfall mimicking enteric-type pulmonary adenocarcinoma. Combined analysis of TTF-1 and Napsin-A improves the specificity of pulmonary adenocarcinoma diagnosis.
Document Type: Article
Other literature type
Language: English
ISSN: 1432-2307
0945-6317
DOI: 10.1007/s00428-024-03926-1
Access URL: https://pubmed.ncbi.nlm.nih.gov/39377914
https://repository.publisso.de/resource/frl:6504593
Rights: CC BY
Accession Number: edsair.doi.dedup.....3e92d0c7805c99079fa94c08c7c821df
Database: OpenAIRE
Description
Abstract:Thyroid transcription factor 1 (TTF-1) immunohistochemistry (IHC) is routinely used for the distinction of primary pulmonary adenocarcinomas. However, TTF-1 can also occur in other malignancies. A tissue microarray containing 17,772 samples from 152 different tumor types was analyzed. Napsin-A, CK20, SATB2, FABP1, and Villin-1 IHC data were available from previous studies. TTF-1 staining was seen in 82 of 152 tumor categories including thyroidal cancers (19–100%), adenocarcinomas (94%), neuroendocrine tumors (67%) of the lung, small cell neuroendocrine carcinomas (71–80%), mesenchymal tumors (up to 42%), and thymomas (39%). Comparative analysis of TTF-1 and Napsin-A revealed a sensitivity/specificity of 94%/86% (TTF-1), 87%/98% (Napsin-A), and 85%/99.1% (TTF-1 and Napsin-A) for the distinction of pulmonary adenocarcinomas. Combined analysis of TTF-1 and enteric markers revealed a positivity for TTF-1 and at least one enteric marker in 22% of pulmonary adenocarcinomas but also a TTF-1 positivity in 6% of colorectal, 2% of pancreatic, and 3% of gastric adenocarcinomas. TTF-1 is a marker of high sensitivity but insufficient specificity for pulmonary adenocarcinomas. A small fraction of TTF-1-positive gastrointestinal adenocarcinomas represents a pitfall mimicking enteric-type pulmonary adenocarcinoma. Combined analysis of TTF-1 and Napsin-A improves the specificity of pulmonary adenocarcinoma diagnosis.
ISSN:14322307
09456317
DOI:10.1007/s00428-024-03926-1