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Quality of life more than 10 years after radiotherapy for localized prostate cancer—impact of time after treatment and prescription dose

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Title: Quality of life more than 10 years after radiotherapy for localized prostate cancer—impact of time after treatment and prescription dose
Authors: Michael Pinkawa, Amr Gharib, Marsha Schlenter, Ludmila Timm, Michael J. Eble
Source: Qual Life Res
Quality of life research 30(2), 437-443 (2021). doi:10.1007/s11136-020-02639-7
Publisher Information: Springer Science and Business Media LLC, 2020.
Publication Year: 2020
Subject Terms: Aged, 80 and over, Male, Time Factors, Dose-Response Relationship, Drug, Dose-Response Relationship, Drug [MeSH], Dose–response relationship, Aged, 80 and over [MeSH], Aged [MeSH], Humans [MeSH], Quality of Life/psychology [MeSH], Middle Aged [MeSH], Prostatic Neoplasms/radiotherapy [MeSH], Time Factors [MeSH], Prostate neoplasms, Article, Quality of life, Male [MeSH], Prostatic Neoplasms/psychology [MeSH], Conformal radiotherapy, Prescriptions [MeSH], Prostatic Neoplasms, Middle Aged, 3. Good health, 03 medical and health sciences, Prescriptions, 0302 clinical medicine, Quality of Life, Humans, Aged
Description: Purpose Analysis of quality of life changes after radiotherapy with focus on the impact of time after treatment and prescription dose. Methods Consecutive patients were treated with doses from 70.2/1.8 Gy (n = 206) to 72/1.8–2.0 Gy (n = 176) in a single centre and surveyed using the Expanded Prostate Cancer Index Composite questionnaire. Results Urinary and bowel bother scores decreased 1 / 3 / 6 points and 7 / 7 / 9 points on average 1 / 5 / 10 years after RT in comparison to baseline scores. The rate of urinary (need of pads in 8% vs. 15% before vs. 10 years after RT; p = 0.01) and bowel (uncontrolled leakage of stool in 5% vs. 12% before vs. 10 years after RT; p A higher dose had a statistically significant impact on urinary bother and stool incontinence, but also tended to decrease urinary continence. Age and comorbidities did not have an influence on score changes, but on baseline urinary function/bother and baseline sexual function. Conclusion Apart from an increasing rate of erectile dysfunction, urinary and bowel incontinence rates increased with increasing follow-up period. A higher dose was found to be associated with increased urinary problems and larger stool incontinence rates. Age and comorbidities were found to be relevant for baseline scores, but not for score changes.
Document Type: Article
Other literature type
Language: English
ISSN: 1573-2649
0962-9343
DOI: 10.1007/s11136-020-02639-7
DOI: 10.18154/rwth-conv-244937
Access URL: https://link.springer.com/content/pdf/10.1007/s11136-020-02639-7.pdf
https://pubmed.ncbi.nlm.nih.gov/33034812
https://www.ncbi.nlm.nih.gov/pubmed/33034812
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886756
https://link.springer.com/article/10.1007/s11136-020-02639-7
https://europepmc.org/article/PMC/PMC7886756
https://link.springer.com/content/pdf/10.1007/s11136-020-02639-7.pdf
https://pubmed.ncbi.nlm.nih.gov/33034812/
https://repository.publisso.de/resource/frl:6468565
https://publications.rwth-aachen.de/record/815085
Rights: CC BY
Accession Number: edsair.doi.dedup.....3e5c77362df8b80878db35d03c55073f
Database: OpenAIRE
Description
Abstract:Purpose Analysis of quality of life changes after radiotherapy with focus on the impact of time after treatment and prescription dose. Methods Consecutive patients were treated with doses from 70.2/1.8 Gy (n = 206) to 72/1.8–2.0 Gy (n = 176) in a single centre and surveyed using the Expanded Prostate Cancer Index Composite questionnaire. Results Urinary and bowel bother scores decreased 1 / 3 / 6 points and 7 / 7 / 9 points on average 1 / 5 / 10 years after RT in comparison to baseline scores. The rate of urinary (need of pads in 8% vs. 15% before vs. 10 years after RT; p = 0.01) and bowel (uncontrolled leakage of stool in 5% vs. 12% before vs. 10 years after RT; p A higher dose had a statistically significant impact on urinary bother and stool incontinence, but also tended to decrease urinary continence. Age and comorbidities did not have an influence on score changes, but on baseline urinary function/bother and baseline sexual function. Conclusion Apart from an increasing rate of erectile dysfunction, urinary and bowel incontinence rates increased with increasing follow-up period. A higher dose was found to be associated with increased urinary problems and larger stool incontinence rates. Age and comorbidities were found to be relevant for baseline scores, but not for score changes.
ISSN:15732649
09629343
DOI:10.1007/s11136-020-02639-7