Neonatal Inflammation and Feeding Disorders at 1 Year in Infants With Congenital Gastrointestinal Malformations
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| Názov: | Neonatal Inflammation and Feeding Disorders at 1 Year in Infants With Congenital Gastrointestinal Malformations |
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| Autori: | Cristina Mastropietro, Gaia Dimino, Nicolas Vinit, Fredérique Quetin, Véronique Rousseau, Victor Sartorius, Elsa Kermorvant‐Duchemin, Alexandre Lapillonne |
| Zdroj: | Acta Paediatr Acta paediatrica, vol. 114, no. 7, pp. 1702-1708 |
| Informácie o vydavateľovi: | Wiley, 2025. |
| Rok vydania: | 2025 |
| Predmety: | Humans, Infant, Newborn, Male, Female, Inflammation/etiology, Inflammation/complications, Infant, Retrospective Studies, C-Reactive Protein/analysis, Digestive System Abnormalities/complications, Prospective Studies, Risk Factors, Feeding and Eating Disorders of Childhood/etiology, Feeding and Eating Disorders of Childhood/epidemiology, congenital gastrointestinal malformations, feeding disorders, inflammation, neonatal surgery, Original Article |
| Popis: | AimTo investigate the associations between inflammatory markers and the risk of paediatric feeding disorders (PFD) at 1 year of age in infants with congenital gastrointestinal malformations (CGMs).MethodsNeonates with CGMs admitted to our NICU and prospectively followed up in our outpatient clinic were included. The presence of PFD was assessed at the 1‐year visit using the Montreal Children's Hospital Feeding Scale (MCH‐FS). Data on potential risk factors for PFD were retrospectively collected.ResultsFifty‐nine neonates were included. They had a median MCH‐FS at 1 year of 25 [IQR = 19–37]. PFD (MCH‐FS > 45) was diagnosed in 15% of cases, of which 56% were severe. The number of days with a C‐reactive protein (CRP) level > 40 mg/L was significantly higher in the PFD patients. After adjusting for confounding factors, a duration of CRP > 40 mg/L remained significantly associated with PFD at 1 year (OR = 1.23, [1.02–1.47]). Similarly, the number of neonatal surgical procedures (OR = 11.4, [2.15–60.6]) was independently associated with PFD at 1 year.ConclusionPFD at 1 year was observed in 15% of newborns with CGMs in our cohort. Our results suggest that sustained severe inflammation caused by surgery and its complications during the neonatal period may have long‐term effects on feeding behaviour. |
| Druh dokumentu: | Article Other literature type |
| Popis súboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1651-2227 0803-5253 |
| DOI: | 10.1111/apa.70025 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/39943894 http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_7677D965F1BC2 https://serval.unil.ch/notice/serval:BIB_7677D965F1BC https://serval.unil.ch/resource/serval:BIB_7677D965F1BC.P001/REF.pdf |
| Rights: | CC BY NC |
| Prístupové číslo: | edsair.doi.dedup.....3bf5d8cda8c7060dd068f2a804cdf924 |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | AimTo investigate the associations between inflammatory markers and the risk of paediatric feeding disorders (PFD) at 1 year of age in infants with congenital gastrointestinal malformations (CGMs).MethodsNeonates with CGMs admitted to our NICU and prospectively followed up in our outpatient clinic were included. The presence of PFD was assessed at the 1‐year visit using the Montreal Children's Hospital Feeding Scale (MCH‐FS). Data on potential risk factors for PFD were retrospectively collected.ResultsFifty‐nine neonates were included. They had a median MCH‐FS at 1 year of 25 [IQR = 19–37]. PFD (MCH‐FS > 45) was diagnosed in 15% of cases, of which 56% were severe. The number of days with a C‐reactive protein (CRP) level > 40 mg/L was significantly higher in the PFD patients. After adjusting for confounding factors, a duration of CRP > 40 mg/L remained significantly associated with PFD at 1 year (OR = 1.23, [1.02–1.47]). Similarly, the number of neonatal surgical procedures (OR = 11.4, [2.15–60.6]) was independently associated with PFD at 1 year.ConclusionPFD at 1 year was observed in 15% of newborns with CGMs in our cohort. Our results suggest that sustained severe inflammation caused by surgery and its complications during the neonatal period may have long‐term effects on feeding behaviour. |
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| ISSN: | 16512227 08035253 |
| DOI: | 10.1111/apa.70025 |