Utility of a simplified [18F] sodium fluoride PET imaging method to quantify bone metabolic flux for a wide range of clinical applications
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| Titel: | Utility of a simplified [18F] sodium fluoride PET imaging method to quantify bone metabolic flux for a wide range of clinical applications |
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| Autoren: | Tanuj Puri, Michelle L. Frost, Amelia E. B. Moore, Ananya Choudhury, Sobhan Vinjamuri, Abhishek Mahajan, Claire Fynbo, Marie Vrist, Jørn Theil, Kalevi Kairemo, James Wong, Habib Zaidi, Mona-Elisabeth Revheim, Thomas J. Werner, Abass Alavi, Gary J. R. Cook, Glen M. Blake |
| Quelle: | Front Endocrinol (Lausanne) Frontiers in Endocrinology, Vol 14 (2023) Puri, T, Frost, M L, Moore, A E B, Choudhury, A, Vinjamuri, S, Mahajan, A, Fynbo, C, Vrist, M, Theil, J, Kairemo, K, Wong, J, Zaidi, H, Revheim, M-E, Werner, T J, Alavi, A N, Cook, G & Blake, G 2023, 'Utility of a simplified [ 18 F] sodium fluoride PET imaging method to quantify bone metabolic flux for a wide range of clinical applications', Frontiers in Endocrinology, vol. 14, 1236881. https://doi.org/10.3389/fendo.2023.1236881 |
| Verlagsinformationen: | Frontiers Media SA, 2023. |
| Publikationsjahr: | 2023 |
| Schlagwörter: | 0301 basic medicine, Positron Emission Tomography Computed Tomography / methods, [18F]NaF, Ki, PET-CT, Bone and Bones / diagnostic imaging, Bone Neoplasms, Clinical applications, clinical applications, Bone metabolic flux, Diseases of the endocrine glands. Clinical endocrinology, Bone and Bones, 03 medical and health sciences, Endocrinology, Positron Emission Tomography Computed Tomography, Humans, quantitative measurement of bone, Positron-Emission Tomography / methods, Quantitative measurement of bone, 0303 health sciences, 616.0757, [ F]NaF, [18F] sodium fluoride, Bone and Bones/diagnostic imaging, Positron-Emission Tomography/methods, RC648-665, future developments, [ F] sodium fluoride, Positron-Emission Tomography, Sodium Fluoride, Future developments, bone metabolic flux, Positron Emission Tomography Computed Tomography/methods |
| Beschreibung: | We review the rationale, methodology, and clinical utility of quantitative [18F] sodium fluoride ([18F]NaF) positron emission tomography-computed tomography (PET-CT) imaging to measure bone metabolic flux (Ki, also known as bone plasma clearance), a measurement indicative of the local rate of bone formation at the chosen region of interest. We review the bone remodelling cycle and explain what aspects of bone remodelling are addressed by [18F]NaF PET-CT. We explain how the technique works, what measurements are involved, and what makes [18F]NaF PET-CT a useful tool for the study of bone remodelling. We discuss how these measurements can be simplified without loss of accuracy to make the technique more accessible. Finally, we briefly review some key clinical applications and discuss the potential for future developments. We hope that the simplified method described here will assist in promoting the wider use of the technique. |
| Publikationsart: | Article Other literature type |
| Dateibeschreibung: | application/pdf |
| ISSN: | 1664-2392 |
| DOI: | 10.3389/fendo.2023.1236881 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/37780613 https://doaj.org/article/ecee5e2d72544041862cd79c8bf9871c https://research.manchester.ac.uk/en/publications/1b2bfb3f-bc66-42ff-87ce-dd39c87a96e6 https://doi.org/10.3389/fendo.2023.1236881 http://www.scopus.com/inward/record.url?scp=85173048500&partnerID=8YFLogxK https://research.manchester.ac.uk/en/publications/1b2bfb3f-bc66-42ff-87ce-dd39c87a96e6 https://doi.org/10.3389/fendo.2023.1236881 https://www.mendeley.com/catalogue/ce82e2ad-a864-353c-9d1a-3443d1c4d124/ https://www.frontiersin.org/articles/10.3389/fendo.2023.1236881/abstract |
| Rights: | CC BY |
| Dokumentencode: | edsair.doi.dedup.....3be099d96ca8a8a3a26d0fa747fdd50e |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | We review the rationale, methodology, and clinical utility of quantitative [18F] sodium fluoride ([18F]NaF) positron emission tomography-computed tomography (PET-CT) imaging to measure bone metabolic flux (Ki, also known as bone plasma clearance), a measurement indicative of the local rate of bone formation at the chosen region of interest. We review the bone remodelling cycle and explain what aspects of bone remodelling are addressed by [18F]NaF PET-CT. We explain how the technique works, what measurements are involved, and what makes [18F]NaF PET-CT a useful tool for the study of bone remodelling. We discuss how these measurements can be simplified without loss of accuracy to make the technique more accessible. Finally, we briefly review some key clinical applications and discuss the potential for future developments. We hope that the simplified method described here will assist in promoting the wider use of the technique. |
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| ISSN: | 16642392 |
| DOI: | 10.3389/fendo.2023.1236881 |