Impact of Imaging-Guided Localization on Performance of Tailored Axillary Surgery in Patients with Clinically Node-Positive Breast Cancer: Prospective Cohort Study Within TAXIS (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101)
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| Název: | Impact of Imaging-Guided Localization on Performance of Tailored Axillary Surgery in Patients with Clinically Node-Positive Breast Cancer: Prospective Cohort Study Within TAXIS (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101) |
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| Autoři: | Weber, Walter P., Heidinger, Martin, Hayoz, Stefanie, Matrai, Zoltan, Tausch, Christoph, Henke, Guido, Zwahlen, Daniel R., Gruber, Günther, Zimmermann, Frank, Montagna, Giacomo, Andreozzi, Mariacarla, Goldschmidt, Maite, Schulz, Alexandra, Mueller, Andreas, Ackerknecht, Markus, Tampaki, Ekaterini Christina, Bjelic-Radisic, Vesna, Kurzeder, Christian, Sávolt, Ákos, Smanykó, Viktor, Hagen, Daniela, Müller, Dieter J., Gnant, Michael, Loibl, Sibylle, Fitzal, Florian, Markellou, Pagona, Bekes, Inga, Egle, Daniel, Heil, Jörg, Knauer, Michael |
| Zdroj: | Ann Surg Oncol |
| Informace o vydavateli: | Springer Science and Business Media LLC, 2023. |
| Rok vydání: | 2023 |
| Témata: | Sentinel Lymph Node Biopsy, Lymphatic Metastasis, Axilla, Lymph Nodes/pathology [MeSH], Breast Neoplasms/diagnostic imaging [MeSH], Breast surgery, Female [MeSH], Humans [MeSH], Prospective Studies [MeSH], Axilla/pathology [MeSH], Breast cancer, Sentinel Lymph Node Biopsy/methods [MeSH], Neoadjuvant Therapy [MeSH], Sentinel lymph node procedure, Axillary staging, Breast Oncology, Lymphatic Metastasis/pathology [MeSH], Lymph Nodes/surgery [MeSH], Breast Neoplasms/surgery [MeSH], Lymph Node Excision/methods [MeSH], Axillary dissection, Breast Neoplasms/pathology [MeSH], Humans, Lymph Node Excision, Female, Breast Neoplasms, Prospective Studies, Lymph Nodes, Neoadjuvant Therapy, 3. Good health |
| Popis: | Background Tailored axillary surgery (TAS) is a novel surgical concept for clinical node-positive breast cancer. It consists of the removal of the sentinel lymph nodes (LNs), as well as palpably suspicious nodes. The TAS technique can be utilized in both the upfront and neoadjuvant chemotherapy (NACT) setting. This study assessed whether/how imaging-guided localization (IGL) influenced TAS. Patients and Methods This was a prospective observational cohort study preplanned in the randomized phase-III OPBC-03/TAXIS trial. IGL was performed at the surgeon’s discretion for targeted removal of LNs during TAS. Immediate back-up axillary lymph node dissection (ALND) followed TAS according to TAXIS randomization. Results Five-hundred patients were included from 44 breast centers in six countries, 151 (30.2%) of whom underwent NACT. IGL was performed in 84.4% of all patients, with significant variation by country (77.6–100%, p < 0.001). No difference in the median number of removed (5 vs. 4, p = 0.3) and positive (2 vs. 2, p = 0.6) LNs by use of IGL was noted. The number of LNs removed during TAS with IGL remained stable over time (p = 0.8), but decreased significantly without IGL, from six (IQR 4–6) in 2019 to four (IQR 3–4) in 2022 (p = 0.015). An ALND was performed in 249 patients, removing another 12 (IQR 9–17) LNs, in which a median number of 1 (IQR 0–4) was positive. There was no significant difference in residual nodal disease after TAS with or without IGL (68.0% vs. 57.6%, p = 0.2). Conclusions IGL did not significantly change either the performance of TAS or the volume of residual nodal tumor burden. Trial registration: ClinicalTrials.gov Identifier: NCT03513614. |
| Druh dokumentu: | Article Other literature type |
| Jazyk: | English |
| ISSN: | 1534-4681 1068-9265 |
| DOI: | 10.1245/s10434-023-14404-4 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/37903951 https://repository.publisso.de/resource/frl:6506208 |
| Rights: | CC BY |
| Přístupové číslo: | edsair.doi.dedup.....3b2ee0d9030f7ac8399ef7b8a865af6e |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Background Tailored axillary surgery (TAS) is a novel surgical concept for clinical node-positive breast cancer. It consists of the removal of the sentinel lymph nodes (LNs), as well as palpably suspicious nodes. The TAS technique can be utilized in both the upfront and neoadjuvant chemotherapy (NACT) setting. This study assessed whether/how imaging-guided localization (IGL) influenced TAS. Patients and Methods This was a prospective observational cohort study preplanned in the randomized phase-III OPBC-03/TAXIS trial. IGL was performed at the surgeon’s discretion for targeted removal of LNs during TAS. Immediate back-up axillary lymph node dissection (ALND) followed TAS according to TAXIS randomization. Results Five-hundred patients were included from 44 breast centers in six countries, 151 (30.2%) of whom underwent NACT. IGL was performed in 84.4% of all patients, with significant variation by country (77.6–100%, p < 0.001). No difference in the median number of removed (5 vs. 4, p = 0.3) and positive (2 vs. 2, p = 0.6) LNs by use of IGL was noted. The number of LNs removed during TAS with IGL remained stable over time (p = 0.8), but decreased significantly without IGL, from six (IQR 4–6) in 2019 to four (IQR 3–4) in 2022 (p = 0.015). An ALND was performed in 249 patients, removing another 12 (IQR 9–17) LNs, in which a median number of 1 (IQR 0–4) was positive. There was no significant difference in residual nodal disease after TAS with or without IGL (68.0% vs. 57.6%, p = 0.2). Conclusions IGL did not significantly change either the performance of TAS or the volume of residual nodal tumor burden. Trial registration: ClinicalTrials.gov Identifier: NCT03513614. |
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| ISSN: | 15344681 10689265 |
| DOI: | 10.1245/s10434-023-14404-4 |