Structural and functional imaging markers for susceptibility to psychosis
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| Názov: | Structural and functional imaging markers for susceptibility to psychosis |
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| Autori: | Christina Andreou, Stefan Borgwardt |
| Zdroj: | Mol Psychiatry |
| Informácie o vydavateľovi: | Springer Science and Business Media LLC, 2020. |
| Rok vydania: | 2020 |
| Predmety: | 03 medical and health sciences, 0302 clinical medicine, Psychotic Disorders, Expert Review, Neuroscience, Psychotic Disorders/diagnostic imaging [MeSH], Psychotic Disorders/diagnosis [MeSH], Humans [MeSH], Neuroimaging [MeSH], Comorbidity [MeSH], Biomarkers [MeSH], Schizophrenia, Disease Susceptibility [MeSH], Humans, Neuroimaging, Comorbidity, Disease Susceptibility, Biomarkers, 3. Good health |
| Popis: | The introduction of clinical criteria for the operationalization of psychosis high risk provided a basis for early detection and treatment of vulnerable individuals. However, about two-thirds of people meeting clinical high-risk (CHR) criteria will never develop a psychotic disorder. In the effort to increase prognostic precision, structural and functional neuroimaging have received growing attention as a potentially useful resource in the prediction of psychotic transition in CHR patients. The present review summarizes current research on neuroimaging biomarkers in the CHR state, with a particular focus on their prognostic utility and limitations. Large, multimodal/multicenter studies are warranted to address issues important for clinical applicability such as generalizability and replicability, standardization of clinical definitions and neuroimaging methods, and consideration of contextual factors (e.g., age, comorbidity). |
| Druh dokumentu: | Article Other literature type |
| Jazyk: | English |
| ISSN: | 1476-5578 1359-4184 |
| DOI: | 10.1038/s41380-020-0679-7 |
| Prístupová URL adresa: | https://www.nature.com/articles/s41380-020-0679-7.pdf https://pubmed.ncbi.nlm.nih.gov/32066828 https://europepmc.org/article/MED/32066828 http://www.ncbi.nlm.nih.gov/pubmed/32066828 https://www.nature.com/articles/s41380-020-0679-7 https://www.nature.com/articles/s41380-020-0679-7.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577836 https://repository.publisso.de/resource/frl:6471336 |
| Rights: | CC BY |
| Prístupové číslo: | edsair.doi.dedup.....3aa3c70a2239b0e68f33b7531709b64e |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | The introduction of clinical criteria for the operationalization of psychosis high risk provided a basis for early detection and treatment of vulnerable individuals. However, about two-thirds of people meeting clinical high-risk (CHR) criteria will never develop a psychotic disorder. In the effort to increase prognostic precision, structural and functional neuroimaging have received growing attention as a potentially useful resource in the prediction of psychotic transition in CHR patients. The present review summarizes current research on neuroimaging biomarkers in the CHR state, with a particular focus on their prognostic utility and limitations. Large, multimodal/multicenter studies are warranted to address issues important for clinical applicability such as generalizability and replicability, standardization of clinical definitions and neuroimaging methods, and consideration of contextual factors (e.g., age, comorbidity). |
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| ISSN: | 14765578 13594184 |
| DOI: | 10.1038/s41380-020-0679-7 |