An 18 year data-linkage study on the association between air pollution and acute limb ischaemia
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| Názov: | An 18 year data-linkage study on the association between air pollution and acute limb ischaemia |
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| Autori: | Fitton, Catherine A., Cox, Bianca, Chalmers, James D., Belch, Jill J.F. |
| Prispievatelia: | Belch, Jill JF/0000-0001-8280-6689, Fitton, Catherine A., COX, Bianca, Chalmers, James D., Belch, Jill J. F. |
| Zdroj: | Vasa. 50:462-467 |
| Informácie o vydavateľovi: | Hogrefe Publishing Group, 2021. |
| Rok vydania: | 2021 |
| Predmety: | AMBIENT-TEMPERATURE, hospital admissions, MODELS, 01 natural sciences, BLOOD MARKERS, DISEASE, 03 medical and health sciences, 0302 clinical medicine, INFLAMMATION, 3203 Dentistry, acute limb ischaemia, PARTICULATE MATTER, Ischemia, death, Air Pollution, 11. Sustainability, pollution, Humans, Aged, Retrospective Studies, 0105 earth and related environmental sciences, RISK, Air Pollutants, Science & Technology, 3202 Clinical sciences, 1103 Clinical Sciences, Aged [MeSH], Humans [MeSH], Air Pollutants/toxicity [MeSH], Ischemia/epidemiology [MeSH], Particulate Matter/analysis [MeSH], Retrospective Studies [MeSH], Air Pollution/analysis [MeSH], Air Pollution/statistics, Ischemia/diagnosis [MeSH], Original communication, Particulate Matter/toxicity [MeSH], Air Pollutants/analysis [MeSH], 3. Good health, THROMBOSIS, RESIDENTIAL EXPOSURE, Peripheral Vascular Disease, Cardiovascular System & Hematology, 13. Climate action, Cardiovascular System & Cardiology, Particulate Matter, 3201 Cardiovascular medicine and haematology, Life Sciences & Biomedicine, name=Cardiology and Cardiovascular Medicine |
| Popis: | Summary: Background: There is limited information regarding the effects of air pollutants, such as nitrogen oxides (NOx), nitric oxide (NO2), nitrous oxide (NO) and particulate matter with a diameter smaller than 10 μm (PM10), on acute limb ischaemia (ALI), a peripheral arterial disease (PAD) often with a poor clinical outcome. Patients and methods: We conducted an 18-year retrospective cohort study using routinely collected healthcare records from Ninewells Hospital, Dundee, and Perth Royal Infirmary, in Tayside, Scotland, UK from 2000 to 2017. ALI hospitalisation events and deaths were linked to daily NOx, NO2, NO and PM10 levels extracted from publicly available data over this same time period. Distributed lag models were used to estimate risk ratios for ALI hospitalisation and for ALI mortality, adjusting for temperature, humidity, day of the week, month and public holiday. Results: 5,608 hospital admissions in 2,697 patients were identified over the study period (mean age 71.2 years, ±11.1). NOx and NO were associated with an increase of ALI hospital admissions on days of exposure to pollutant (p=.018), while PM10 was associated with a cumulative (lag 0–9 days) increase (p=.027) of ALI hospital admissions in our study. There was no increase of ALI mortality associated with pollution levels. Conclusions: ALI hospital admissions were positively associated with ambient NOx and NO on day of high measured pollution levels and a cumulative effect was seen with PM10. |
| Druh dokumentu: | Article |
| Popis súboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1664-2872 0301-1526 |
| DOI: | 10.1024/0301-1526/a000972 |
| Prístupová URL adresa: | https://econtent.hogrefe.com/doi/pdf/10.1024/0301-1526/a000972 https://pubmed.ncbi.nlm.nih.gov/34743586 https://discovery.dundee.ac.uk/en/publications/an-18-year-data-linkage-study-on-the-association-between-air-poll https://econtent.hogrefe.com/doi/10.1024/0301-1526/a000972 https://europepmc.org/article/MED/34743586 https://pubmed.ncbi.nlm.nih.gov/34743586/ https://lirias.kuleuven.be/handle/20.500.12942/707638 https://doi.org/10.1024/0301-1526/a000972 https://repository.publisso.de/resource/frl:6479448 http://hdl.handle.net/1942/36714 |
| Rights: | CC BY ND CC BY NC ND |
| Prístupové číslo: | edsair.doi.dedup.....39c8dc364482910ce83c9adcfdff230d |
| Databáza: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstrakt: | Summary: Background: There is limited information regarding the effects of air pollutants, such as nitrogen oxides (NOx), nitric oxide (NO2), nitrous oxide (NO) and particulate matter with a diameter smaller than 10 μm (PM10), on acute limb ischaemia (ALI), a peripheral arterial disease (PAD) often with a poor clinical outcome. Patients and methods: We conducted an 18-year retrospective cohort study using routinely collected healthcare records from Ninewells Hospital, Dundee, and Perth Royal Infirmary, in Tayside, Scotland, UK from 2000 to 2017. ALI hospitalisation events and deaths were linked to daily NOx, NO2, NO and PM10 levels extracted from publicly available data over this same time period. Distributed lag models were used to estimate risk ratios for ALI hospitalisation and for ALI mortality, adjusting for temperature, humidity, day of the week, month and public holiday. Results: 5,608 hospital admissions in 2,697 patients were identified over the study period (mean age 71.2 years, ±11.1). NOx and NO were associated with an increase of ALI hospital admissions on days of exposure to pollutant (p=.018), while PM10 was associated with a cumulative (lag 0–9 days) increase (p=.027) of ALI hospital admissions in our study. There was no increase of ALI mortality associated with pollution levels. Conclusions: ALI hospital admissions were positively associated with ambient NOx and NO on day of high measured pollution levels and a cumulative effect was seen with PM10. |
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| ISSN: | 16642872 03011526 |
| DOI: | 10.1024/0301-1526/a000972 |