Parental occupational exposure to solvents and heavy metals and risk of developing testicular germ cell tumors in sons (NORD-TEST Denmark)
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| Názov: | Parental occupational exposure to solvents and heavy metals and risk of developing testicular germ cell tumors in sons (NORD-TEST Denmark) |
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| Autori: | Olsson, Ann, Togawa, Kayo, Schüz, Joachim, Le Cornet, Charlotte, Fervers, Beatrice, Oksbjerg Dalton, Susanne, Pukkala, Eero, Feychting, Maria, Skakkebæk, Niels Erik, Hansen, Johnni |
| Prispievatelia: | University of Tampere |
| Zdroj: | Scandinavian Journal of Work, Environment & Health, Vol 44, Iss 6, Pp 658-669 (2018) Olsson, A, Togawa, K, Schüz, J, Le Cornet, C, Fervers, B, Oksbjerg Dalton, S, Pukkala, E, Maria Feychting, M F, Skakkebæk, N E & Hansen, J 2018, ' Parental occupational exposure to solvents and heavy metals and risk of developing testicular germ cell tumors in sons (NORD-TEST Denmark) ', Scandinavian Journal of Work, Environment & Health, vol. 44, no. 6, pp. 658-669 . https://doi.org/10.5271/sjweh.3732 |
| Informácie o vydavateľovi: | Scandinavian Journal of Work, Environment and Health, 2018. |
| Rok vydania: | 2018 |
| Predmety: | Adult, Male, Adolescent, Denmark, Testicular Neoplasms/epidemiology, statistics denmark, prenatal risk factor, solvent, Nuclear Family, 03 medical and health sciences, 0302 clinical medicine, Testicular Neoplasms, Neoplasms, Syöpätaudit - Cancers, Paternal Exposure/adverse effects, Metals, Heavy, Occupational Exposure, perinatal risk factor, cancer, toluene, Humans, nord-test, Registries, nocca-jem, chromium vi, danish cancer registry, Germ Cell and Embryonal/epidemiology, occupational exposure, denmark, heavy metal, Neoplasms, Germ Cell and Embryonal, Neoplasms, Germ Cell and Embryonal/epidemiology, Denmark/epidemiology, parental occupational exposure, Metals, Heavy/toxicity, Solvents/toxicity, Paternal Exposure, case−control study, Solvents, Metals, Heavy/toxicity, danish supplementary pension fund, testicular germ cell tumor, Public aspects of medicine, RA1-1270 |
| Popis: | Objective The present study aims to assess if parental occupational exposure to solvents or heavy metals is associated with risk of testicular germ cell tumors (TGCT) in sons in Denmark. Methods The NORD-TEST Denmark included 3421 cases diagnosed with TGCT at ages 14-49 years in Denmark between 1981 and 2014. Controls (N=14 024) selected from the central population registry were matched to cases on birth year. The Danish Supplementary Pension Fund provided parental occupational information. A job-exposure matrix was used to assign exposures, and conditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results The overall analyses showed no significant associations except for paternal exposure to a sub-group of "heavy metal(s) and solvent(s)" (OR 1.50, 95% CI 1.01-2.24). Most fathers in this category had worked in wood related jobs and were assigned exposure to chromium VI and toluene. Other sub-group analyses suggested that maternal exposure to aromatic hydrocarbon were associated with TGCT risk, in sons born in 1970-1979, and to heavy metals (chromium, iron and nickel) in sons born in 1980-1998. Conclusion NORD-TEST Denmark provides no strong support for an association between parental exposures to solvents or heavy metals and TGCT in sons, and only weak support for an association between paternal exposure to chromium and toluene and TGCT risk in sons. |
| Druh dokumentu: | Article |
| Popis súboru: | application/pdf; fulltext |
| Jazyk: | English |
| ISSN: | 1795-990X 0355-3140 |
| DOI: | 10.5271/sjweh.3732 |
| Prístupová URL adresa: | https://www.sjweh.fi/download.php?abstract_id=3732&file_nro=1 https://pubmed.ncbi.nlm.nih.gov/29877553 https://doaj.org/article/9c8d99824bfd4fd58a8f57e1197c4ac9 https://pubmed.ncbi.nlm.nih.gov/29877553/ https://www.airitilibrary.com/Publication/alDetailedMesh?DocID=03553140-201811-201811190016-201811190016-658-669 https://www.ncbi.nlm.nih.gov/pubmed/29877553 https://www.sjweh.fi/show_abstract.php?abstract_id=3732 http://www.ncbi.nlm.nih.gov/pubmed/29877553 http://europepmc.org/abstract/MED/29877553 https://curis.ku.dk/ws/files/217938283/658_669_olsson.pdf https://trepo.tuni.fi/handle/10024/104515 |
| Rights: | CC BY |
| Prístupové číslo: | edsair.doi.dedup.....39a3761faaa3d4981109b07c05ca6e8c |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Objective The present study aims to assess if parental occupational exposure to solvents or heavy metals is associated with risk of testicular germ cell tumors (TGCT) in sons in Denmark. Methods The NORD-TEST Denmark included 3421 cases diagnosed with TGCT at ages 14-49 years in Denmark between 1981 and 2014. Controls (N=14 024) selected from the central population registry were matched to cases on birth year. The Danish Supplementary Pension Fund provided parental occupational information. A job-exposure matrix was used to assign exposures, and conditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results The overall analyses showed no significant associations except for paternal exposure to a sub-group of "heavy metal(s) and solvent(s)" (OR 1.50, 95% CI 1.01-2.24). Most fathers in this category had worked in wood related jobs and were assigned exposure to chromium VI and toluene. Other sub-group analyses suggested that maternal exposure to aromatic hydrocarbon were associated with TGCT risk, in sons born in 1970-1979, and to heavy metals (chromium, iron and nickel) in sons born in 1980-1998. Conclusion NORD-TEST Denmark provides no strong support for an association between parental exposures to solvents or heavy metals and TGCT in sons, and only weak support for an association between paternal exposure to chromium and toluene and TGCT risk in sons. |
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| ISSN: | 1795990X 03553140 |
| DOI: | 10.5271/sjweh.3732 |