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Parental occupational exposure to solvents and heavy metals and risk of developing testicular germ cell tumors in sons (NORD-TEST Denmark)

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Title: Parental occupational exposure to solvents and heavy metals and risk of developing testicular germ cell tumors in sons (NORD-TEST Denmark)
Authors: Olsson, Ann, Togawa, Kayo, Schüz, Joachim, Le Cornet, Charlotte, Fervers, Beatrice, Oksbjerg Dalton, Susanne, Pukkala, Eero, Feychting, Maria, Skakkebæk, Niels Erik, Hansen, Johnni
Contributors: University of Tampere
Source: Scandinavian Journal of Work, Environment & Health, Vol 44, Iss 6, Pp 658-669 (2018)
Olsson, A, Togawa, K, Schüz, J, Le Cornet, C, Fervers, B, Oksbjerg Dalton, S, Pukkala, E, Maria Feychting, M F, Skakkebæk, N E & Hansen, J 2018, ' Parental occupational exposure to solvents and heavy metals and risk of developing testicular germ cell tumors in sons (NORD-TEST Denmark) ', Scandinavian Journal of Work, Environment & Health, vol. 44, no. 6, pp. 658-669 . https://doi.org/10.5271/sjweh.3732
Publisher Information: Scandinavian Journal of Work, Environment and Health, 2018.
Publication Year: 2018
Subject Terms: Adult, Male, Adolescent, Denmark, Testicular Neoplasms/epidemiology, statistics denmark, prenatal risk factor, solvent, Nuclear Family, 03 medical and health sciences, 0302 clinical medicine, Testicular Neoplasms, Neoplasms, Syöpätaudit - Cancers, Paternal Exposure/adverse effects, Metals, Heavy, Occupational Exposure, perinatal risk factor, cancer, toluene, Humans, nord-test, Registries, nocca-jem, chromium vi, danish cancer registry, Germ Cell and Embryonal/epidemiology, occupational exposure, denmark, heavy metal, Neoplasms, Germ Cell and Embryonal, Neoplasms, Germ Cell and Embryonal/epidemiology, Denmark/epidemiology, parental occupational exposure, Metals, Heavy/toxicity, Solvents/toxicity, Paternal Exposure, case−control study, Solvents, Metals, Heavy/toxicity, danish supplementary pension fund, testicular germ cell tumor, Public aspects of medicine, RA1-1270
Description: Objective The present study aims to assess if parental occupational exposure to solvents or heavy metals is associated with risk of testicular germ cell tumors (TGCT) in sons in Denmark. Methods The NORD-TEST Denmark included 3421 cases diagnosed with TGCT at ages 14-49 years in Denmark between 1981 and 2014. Controls (N=14 024) selected from the central population registry were matched to cases on birth year. The Danish Supplementary Pension Fund provided parental occupational information. A job-exposure matrix was used to assign exposures, and conditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results The overall analyses showed no significant associations except for paternal exposure to a sub-group of "heavy metal(s) and solvent(s)" (OR 1.50, 95% CI 1.01-2.24). Most fathers in this category had worked in wood related jobs and were assigned exposure to chromium VI and toluene. Other sub-group analyses suggested that maternal exposure to aromatic hydrocarbon were associated with TGCT risk, in sons born in 1970-1979, and to heavy metals (chromium, iron and nickel) in sons born in 1980-1998. Conclusion NORD-TEST Denmark provides no strong support for an association between parental exposures to solvents or heavy metals and TGCT in sons, and only weak support for an association between paternal exposure to chromium and toluene and TGCT risk in sons.
Document Type: Article
File Description: application/pdf; fulltext
Language: English
ISSN: 1795-990X
0355-3140
DOI: 10.5271/sjweh.3732
Access URL: https://www.sjweh.fi/download.php?abstract_id=3732&file_nro=1
https://pubmed.ncbi.nlm.nih.gov/29877553
https://doaj.org/article/9c8d99824bfd4fd58a8f57e1197c4ac9
https://pubmed.ncbi.nlm.nih.gov/29877553/
https://www.airitilibrary.com/Publication/alDetailedMesh?DocID=03553140-201811-201811190016-201811190016-658-669
https://www.ncbi.nlm.nih.gov/pubmed/29877553
https://www.sjweh.fi/show_abstract.php?abstract_id=3732
http://www.ncbi.nlm.nih.gov/pubmed/29877553
http://europepmc.org/abstract/MED/29877553
https://curis.ku.dk/ws/files/217938283/658_669_olsson.pdf
https://trepo.tuni.fi/handle/10024/104515
Rights: CC BY
Accession Number: edsair.doi.dedup.....39a3761faaa3d4981109b07c05ca6e8c
Database: OpenAIRE
Description
Abstract:Objective The present study aims to assess if parental occupational exposure to solvents or heavy metals is associated with risk of testicular germ cell tumors (TGCT) in sons in Denmark. Methods The NORD-TEST Denmark included 3421 cases diagnosed with TGCT at ages 14-49 years in Denmark between 1981 and 2014. Controls (N=14 024) selected from the central population registry were matched to cases on birth year. The Danish Supplementary Pension Fund provided parental occupational information. A job-exposure matrix was used to assign exposures, and conditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results The overall analyses showed no significant associations except for paternal exposure to a sub-group of "heavy metal(s) and solvent(s)" (OR 1.50, 95% CI 1.01-2.24). Most fathers in this category had worked in wood related jobs and were assigned exposure to chromium VI and toluene. Other sub-group analyses suggested that maternal exposure to aromatic hydrocarbon were associated with TGCT risk, in sons born in 1970-1979, and to heavy metals (chromium, iron and nickel) in sons born in 1980-1998. Conclusion NORD-TEST Denmark provides no strong support for an association between parental exposures to solvents or heavy metals and TGCT in sons, and only weak support for an association between paternal exposure to chromium and toluene and TGCT risk in sons.
ISSN:1795990X
03553140
DOI:10.5271/sjweh.3732