Prevalence of micro- and macrovascular diabetes complications at time of type 2 diabetes diagnosis and associated clinical characteristics: A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort: A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort
Uložené v:
| Názov: | Prevalence of micro- and macrovascular diabetes complications at time of type 2 diabetes diagnosis and associated clinical characteristics: A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort: A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort |
|---|---|
| Autori: | Allan Vaag, Anne Gedebjerg, Henrik Toft Sørensen, Søren Friborg, Reimar W. Thomsen, Jens Steen Nielsen, Henning Beck-Nielsen, Daniel R. Witte, Klara Berencsi, Thomas Almdal, Jørgen Rungby, Ivan Brandslund |
| Zdroj: | Gedebjerg, A, Almdal, T P, Berencsi, K, Rungby, J, Nielsen, J S, Witte, D R, Friborg, S, Brandslund, I, Vaag, A, Beck-Nielsen, H, Sørensen, H T & Thomsen, R W 2018, ' Prevalence of micro-and macrovascular diabetes complications at time of type 2 diabetes diagnosis and associated clinical characteristics : A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort ', Journal of Diabetes and its Complications, vol. 32, no. 1, pp. 34-40 . https://doi.org/10.1016/j.jdiacomp.2017.09.010 Gedebjerg, A, Almdal, T P, Berencsi, K, Rungby, J, Nielsen, J S, Witte, D R, Friborg, S, Brandslund, I, Vaag, A, Beck-Nielsen, H, Sørensen, H T & Thomsen, R W 2018, 'Prevalence of micro-and macrovascular diabetes complications at time of type 2 diabetes diagnosis and associated clinical characteristics: A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort', Journal of Diabetes and its Complications, vol. 32, no. 1, pp. 34-40. https://doi.org/10.1016/j.jdiacomp.2017.09.010 |
| Informácie o vydavateľovi: | Elsevier BV, 2018. |
| Rok vydania: | 2018 |
| Predmety: | Adult, Male, Microvascular complications, Delayed Diagnosis, Time Factors, Epidemiology, Denmark, Diabetes Complications/epidemiology, Cohort Studies, Diabetes Complications, 03 medical and health sciences, 0302 clinical medicine, Journal Article, Diabetes Mellitus, 80 and over, Prevalence, Humans, Macrovascular complications, Aged, Aged, 80 and over, Diabetic Angiopathies/classification, Diabetes Mellitus, Type 2/complications, Type 2 diabetes, Middle Aged, Type 2/complications, Denmark/epidemiology, 3. Good health, Cross-Sectional Studies, Risk factors, Diabetes Mellitus, Type 2, Female, Diabetic Angiopathies, Delayed Diagnosis/statistics & numerical data |
| Popis: | To examine the prevalence of micro- and macrovascular complications and their associated clinical characteristics at time of type 2 diabetes (T2D) diagnosis.We examined the prevalence of complications and associated clinical characteristics among 6958 newly diagnosed T2D patients enrolled in the prospective Danish Center for Strategic Research in T2D cohort during 2010-2016. We calculated age- and gender-adjusted prevalence ratios (aPRs) of complications using log-binomial and Poisson regression.In total, 35% (n=2456) T2D patients had diabetic complications around diagnosis; 12% (n=828) had microvascular complications, 17% (n=1186) macrovascular complications, and 6% (n=442) had both. HbA1c levels of ≥7% were associated with microvascular complications [HbA1c 7%-8%; aPR: 1.35, 95% confidence interval (CI): 1.12-1.62] but not macrovascular complications [aPR: 0.91, 95% CI: 0.76-1.08]. High C-peptide≥800pmol/L was associated with macrovascular [aPR 1.34, 95% CI: 1.00-1.80] but not microvascular [aPR 0.97, 95% CI: 0.71-1.33] complications. Macrovascular complications were associated with male sex, age>50years, obesity, hypertriglyceridemia, low HDL cholesterol, smoking, elevated CRP levels, and anti-hypertensive therapy. Microvascular complications were associated with high blood pressure, hypertriglyceridemia, and absence of lipid-lowering therapy.One-third of patients with T2D had diabetes complications around time of diagnosis. Our findings suggest different pathophysiological mechanisms behind micro- and macrovascular complications. |
| Druh dokumentu: | Article |
| Popis súboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1056-8727 |
| DOI: | 10.1016/j.jdiacomp.2017.09.010 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/29107454 https://www.ndorms.ox.ac.uk/publications/745839 https://portal.findresearcher.sdu.dk/da/publications/prevalence-of-micro-and-macrovascular-diabetes-complications-at-t http://findresearcher.sdu.dk/portal/da/publications/prevalence-of-micro-and-macrovascular-diabetes-complications-at-time-of-type-2-diabetes-diagnosis-and-associated-clinical-characteristics(fb3dfbf8-43e0-4001-8de2-f69875d45592).html https://www.sciencedirect.com/science/article/pii/S1056872717308991 https://pubmed.ncbi.nlm.nih.gov/29107454/ https://findresearcher.sdu.dk:8443/ws/files/134149535/Prevalence_of_micro_and_macrovascular_diabetes_complications_at_time_of_type_2_diabetes_diagnosis_and_associated_clinical_characteristics.pdf https://findresearcher.sdu.dk:8443/ws/files/134149535/Prevalence_of_micro_and_macrovascular_diabetes_complications_at_time_of_type_2_diabetes_diagnosis_and_associated_clinical_characteristics.pdf https://portal.findresearcher.sdu.dk/da/publications/fb3dfbf8-43e0-4001-8de2-f69875d45592 https://doi.org/10.1016/j.jdiacomp.2017.09.010 |
| Rights: | Elsevier TDM CC BY NC ND |
| Prístupové číslo: | edsair.doi.dedup.....39640e820ea2293d93489f1242cbfa23 |
| Databáza: | OpenAIRE |
Full Text Finder 
Nájsť tento článok vo Web of Science | Abstrakt: | To examine the prevalence of micro- and macrovascular complications and their associated clinical characteristics at time of type 2 diabetes (T2D) diagnosis.We examined the prevalence of complications and associated clinical characteristics among 6958 newly diagnosed T2D patients enrolled in the prospective Danish Center for Strategic Research in T2D cohort during 2010-2016. We calculated age- and gender-adjusted prevalence ratios (aPRs) of complications using log-binomial and Poisson regression.In total, 35% (n=2456) T2D patients had diabetic complications around diagnosis; 12% (n=828) had microvascular complications, 17% (n=1186) macrovascular complications, and 6% (n=442) had both. HbA1c levels of ≥7% were associated with microvascular complications [HbA1c 7%-8%; aPR: 1.35, 95% confidence interval (CI): 1.12-1.62] but not macrovascular complications [aPR: 0.91, 95% CI: 0.76-1.08]. High C-peptide≥800pmol/L was associated with macrovascular [aPR 1.34, 95% CI: 1.00-1.80] but not microvascular [aPR 0.97, 95% CI: 0.71-1.33] complications. Macrovascular complications were associated with male sex, age>50years, obesity, hypertriglyceridemia, low HDL cholesterol, smoking, elevated CRP levels, and anti-hypertensive therapy. Microvascular complications were associated with high blood pressure, hypertriglyceridemia, and absence of lipid-lowering therapy.One-third of patients with T2D had diabetes complications around time of diagnosis. Our findings suggest different pathophysiological mechanisms behind micro- and macrovascular complications. |
|---|---|
| ISSN: | 10568727 |
| DOI: | 10.1016/j.jdiacomp.2017.09.010 |