View in EDS

Temporal variation in nutritional status and preoperative anemia among patients with retroperitoneal soft tissue sarcoma: a retrospective longitudinal cohort study

Saved in:
Bibliographic Details
Title: Temporal variation in nutritional status and preoperative anemia among patients with retroperitoneal soft tissue sarcoma: a retrospective longitudinal cohort study
Authors: Willis, Franziska, Trunk, Anna-Marlen, Musa, Julian, Harnoss, Jonathan M., Strowitzki, Moritz J., Engerer, Cosima, Harnoss, Julian-C., Al-Saeedi, Mohammed, Büchler, Markus W., Schneider, Martin
Source: Langenbecks Arch Surg
Publisher Information: Springer Science and Business Media LLC, 2025.
Publication Year: 2025
Subject Terms: Male, Adult, Research, Nutritional Status, Anemia, Sarcoma, Middle Aged, Hemoglobins, Aged [MeSH], Retroperitoneal Neoplasms/surgery [MeSH], Sarcoma/surgery [MeSH], Sarcoma/mortality [MeSH], Retroperitoneal Neoplasms/mortality [MeSH], Cohort Studies [MeSH], Male [MeSH], Preoperative Period [MeSH], Neoplasm Recurrence, Local [MeSH], Retroperitoneal Neoplasms/complications [MeSH], Hemoglobin, Female [MeSH], Sarcoma/complications [MeSH], Adult [MeSH], Humans [MeSH], Multivisceral resection, Hemoglobins/analysis [MeSH], Overall survival, Longitudinal Studies [MeSH], Retrospective Studies [MeSH], Middle Aged [MeSH], Nutritional status, Anemia/complications [MeSH], Sarcoma/pathology [MeSH], Preoperative anemia, Retroperitoneal soft tissue sarcoma, Prognosis [MeSH], Nutritional Status [MeSH], Retroperitoneal Neoplasms/pathology [MeSH], Preoperative Period, Humans, Female, Retroperitoneal Neoplasms, Longitudinal Studies, Neoplasm Recurrence, Local, Retrospective Studies, Aged
Description: Purpose Optimal management of retroperitoneal soft tissue sarcoma (RPS) often requires extensive tumor resections, frequently involving gastrointestinal organs. The impact of these procedures on the nutritional status and hemoglobin (Hb) levels of RPS patients remain unexplored. In this study, we aimed to evaluate preoperative nutritional status as well as the prevalence of anemia in RPS patients, and to investigate longitudinal changes throughout the disease course in order to identify potential strategies for prehabilitation. Materials and methods Patients undergoing resection of primary and recurrent RPS at Heidelberg University Hospital were retrospectively analyzed. Changes in nutritional parameters and Hb levels throughout the disease course were analyzed using hierarchical linear regression models. Multivariable Cox regression analyses were performed to identify independent predictors of overall survival. Subgroup analyses were conducted for primary tumors, first, second and third recurrences. Results Amongst 370 patients analyzed, comprising 219 with primary disease, we observed neither a significant prevalence of preoperative malnutrition nor notable changes in BMI or serum albumin levels throughout the disease course. Preoperative anemia affected up to 40% of RPS patients, and Hb levels significantly decreased over the course of the disease (p = 0.022), particularly in correlation with the number of tumor resections performed (p = 0.010). Low preoperative Hb levels were associated with increased 30-day mortality and they were identified as an independent prognostic factor for shorter overall survival in primary RPS as well as in second and third recurrences. Conclusion Anemia screening should be performed preoperatively and during regular follow-ups to enable early-on therapy, thus potentially improving patient outcomes in RPS.
Document Type: Article
Other literature type
Language: English
ISSN: 1435-2451
DOI: 10.1007/s00423-024-03585-5
Access URL: https://pubmed.ncbi.nlm.nih.gov/39841283
https://repository.publisso.de/resource/frl:6489858
Rights: CC BY
Accession Number: edsair.doi.dedup.....393a2360ad7e268035cd15df6bb4c8d5
Database: OpenAIRE
Description
Abstract:Purpose Optimal management of retroperitoneal soft tissue sarcoma (RPS) often requires extensive tumor resections, frequently involving gastrointestinal organs. The impact of these procedures on the nutritional status and hemoglobin (Hb) levels of RPS patients remain unexplored. In this study, we aimed to evaluate preoperative nutritional status as well as the prevalence of anemia in RPS patients, and to investigate longitudinal changes throughout the disease course in order to identify potential strategies for prehabilitation. Materials and methods Patients undergoing resection of primary and recurrent RPS at Heidelberg University Hospital were retrospectively analyzed. Changes in nutritional parameters and Hb levels throughout the disease course were analyzed using hierarchical linear regression models. Multivariable Cox regression analyses were performed to identify independent predictors of overall survival. Subgroup analyses were conducted for primary tumors, first, second and third recurrences. Results Amongst 370 patients analyzed, comprising 219 with primary disease, we observed neither a significant prevalence of preoperative malnutrition nor notable changes in BMI or serum albumin levels throughout the disease course. Preoperative anemia affected up to 40% of RPS patients, and Hb levels significantly decreased over the course of the disease (p = 0.022), particularly in correlation with the number of tumor resections performed (p = 0.010). Low preoperative Hb levels were associated with increased 30-day mortality and they were identified as an independent prognostic factor for shorter overall survival in primary RPS as well as in second and third recurrences. Conclusion Anemia screening should be performed preoperatively and during regular follow-ups to enable early-on therapy, thus potentially improving patient outcomes in RPS.
ISSN:14352451
DOI:10.1007/s00423-024-03585-5