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Differences in the prevalence of erectile dysfunction between novel subgroups of recent-onset diabetes

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Názov: Differences in the prevalence of erectile dysfunction between novel subgroups of recent-onset diabetes
Autori: Haifa Maalmi, Christian Herder, Gidon J. Bönhof, Klaus Strassburger, Oana-Patricia Zaharia, Wolfgang Rathmann, Volker Burkart, Julia Szendroedi, Michael Roden, Dan Ziegler
Zdroj: Diabetologia
Informácie o vydavateľovi: Springer Science and Business Media LLC, 2021.
Rok vydania: 2021
Predmety: Male, 03 medical and health sciences, Diabetes Mellitus, Type 2/epidemiology [MeSH], Diabetes Mellitus, Type 1/epidemiology [MeSH], Diabetes Mellitus, Type 2/complications [MeSH], Insulin resistance, Humans [MeSH], Inflammation, Risk Factors [MeSH], Cross-Sectional Studies [MeSH], Erectile Dysfunction/epidemiology [MeSH], Article, Male [MeSH], Erectile Dysfunction/complications [MeSH], Erectile dysfunction, Diabetes subgroups, Prevalence [MeSH], New-onset diabetes, Cross-Sectional Studies, Diabetes Mellitus, Type 1, 0302 clinical medicine, Diabetes Mellitus, Type 2, Erectile Dysfunction, Risk Factors, Prevalence, Humans, 3. Good health
Popis: Aims/hypothesis In men with diabetes, the prevalence of erectile dysfunction increases with advanced age and longer diabetes duration and is substantially higher in men with type 2 diabetes than those with type 1 diabetes. This study aimed to evaluate the prevalence of erectile dysfunction among the five novel subgroups of recent-onset diabetes and determine the strength of associations between diabetes subgroups and erectile dysfunction. Methods A total of 351 men with recent-onset diabetes ( Results The prevalence of erectile dysfunction was markedly higher in men with diabetes than in men without diabetes (23% vs 11%, p = 0.004). Among men with diabetes, the prevalence of erectile dysfunction was highest in men with severe insulin-resistant diabetes (SIRD) (52%), lowest in men with severe autoimmune diabetes (SAID) (7%), and intermediate in men with severe insulin-deficient diabetes (SIDD), mild obesity-related diabetes (MOD) and mild age-related diabetes (MARD) (31%, 18% and 29%, respectively). Men with SIRD had an adjusted RR of 1.93 (95% CI 1.04, 3.58) for prevalent erectile dysfunction (p = 0.038). Similarly, men with SIDD had an adjusted RR of 3.27 (95% CI 1.18, 9.10) (p = 0.023). In contrast, men with SAID and those with MARD had unadjusted RRs of 0.26 (95% CI 0.11, 0.58) (p = 0.001) and 1.52 (95% CI 1.04, 2.22) (p = 0.027), respectively. However, these associations did not remain statistically significant after adjustment. Conclusions/interpretation The high RRs for erectile dysfunction in men with recent-onset SIRD and SIDD point to both insulin resistance and insulin deficiency as major contributing factors to this complication, suggesting different mechanisms underlying erectile dysfunction in these subgroups. Graphical abstract
Druh dokumentu: Article
Other literature type
Jazyk: English
ISSN: 1432-0428
0012-186X
DOI: 10.1007/s00125-021-05607-z
Prístupová URL adresa: https://link.springer.com/content/pdf/10.1007/s00125-021-05607-z.pdf
https://pubmed.ncbi.nlm.nih.gov/34800144
https://link.springer.com/article/10.1007/s00125-021-05607-z
https://link.springer.com/content/pdf/10.1007/s00125-021-05607-z.pdf
https://www.ncbi.nlm.nih.gov/pubmed/34800144
https://repository.publisso.de/resource/frl:6451886
Rights: CC BY
Prístupové číslo: edsair.doi.dedup.....379611c2cfeebe928ceaf865feafa41d
Databáza: OpenAIRE
Popis
Abstrakt:Aims/hypothesis In men with diabetes, the prevalence of erectile dysfunction increases with advanced age and longer diabetes duration and is substantially higher in men with type 2 diabetes than those with type 1 diabetes. This study aimed to evaluate the prevalence of erectile dysfunction among the five novel subgroups of recent-onset diabetes and determine the strength of associations between diabetes subgroups and erectile dysfunction. Methods A total of 351 men with recent-onset diabetes ( Results The prevalence of erectile dysfunction was markedly higher in men with diabetes than in men without diabetes (23% vs 11%, p = 0.004). Among men with diabetes, the prevalence of erectile dysfunction was highest in men with severe insulin-resistant diabetes (SIRD) (52%), lowest in men with severe autoimmune diabetes (SAID) (7%), and intermediate in men with severe insulin-deficient diabetes (SIDD), mild obesity-related diabetes (MOD) and mild age-related diabetes (MARD) (31%, 18% and 29%, respectively). Men with SIRD had an adjusted RR of 1.93 (95% CI 1.04, 3.58) for prevalent erectile dysfunction (p = 0.038). Similarly, men with SIDD had an adjusted RR of 3.27 (95% CI 1.18, 9.10) (p = 0.023). In contrast, men with SAID and those with MARD had unadjusted RRs of 0.26 (95% CI 0.11, 0.58) (p = 0.001) and 1.52 (95% CI 1.04, 2.22) (p = 0.027), respectively. However, these associations did not remain statistically significant after adjustment. Conclusions/interpretation The high RRs for erectile dysfunction in men with recent-onset SIRD and SIDD point to both insulin resistance and insulin deficiency as major contributing factors to this complication, suggesting different mechanisms underlying erectile dysfunction in these subgroups. Graphical abstract
ISSN:14320428
0012186X
DOI:10.1007/s00125-021-05607-z