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Relationship between kinetic parameters of ultrafast dynamic contrast-enhanced (DCE) MRI and tumor-infiltrating lymphocytes (TILs) in breast cancer

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Název: Relationship between kinetic parameters of ultrafast dynamic contrast-enhanced (DCE) MRI and tumor-infiltrating lymphocytes (TILs) in breast cancer
Autoři: Ken Yamaguchi, Takahiko Nakazono, Ryoko Egashira, Shuichi Fukui, Tsutomu Imaizumi, Katsuya Maruyama, Dominik Nickel, Takahiro Hamamoto, Rin Yamaguchi, Hiroyuki Irie
Zdroj: Jpn J Radiol
Informace o vydavateli: Springer Science and Business Media LLC, 2024.
Rok vydání: 2024
Témata: 03 medical and health sciences, 0302 clinical medicine, Original Article, Breast Neoplasms/diagnostic imaging [MeSH], Female [MeSH], Aged, 80 and over [MeSH], Aged [MeSH], Adult [MeSH], Humans [MeSH], Breast cancer, TILs, Retrospective Studies [MeSH], Middle Aged [MeSH], Prognosis, Contrast Media [MeSH], Ultrafast, Breast Neoplasms/immunology [MeSH], Lymphocytes, Tumor-Infiltrating/immunology [MeSH], Image Enhancement/methods [MeSH], Magnetic resonance imaging, Magnetic Resonance Imaging/methods [MeSH], 3. Good health
Popis: Purpose To evaluate the relationship between kinetic parameters of ultrafast dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and tumor-infiltrating lymphocytes (TILs) in breast cancer. Patients and methods This retrospective study was approved by an institutional review board and included 76 women (median age: 60) with 76 surgically proven breast cancers who underwent DCE MRI including ultrafast sequence. Based on the TILs level, we classified the patients into the low-TILs ( Results Of the 76 breast cancers, 57 were in the low-TILs group and 19 comprised the high-TILs group. The median MS in the high-TILs group (32.4%/sec) was significantly higher than that in the low-TILs group (23.68%/s) (p = 0.037). In a receiver-operating characteristic (ROC) analysis, the area under the curve (AUC) for differentiating between the high- and low-TILs group was 0.661. The TTE in the high-TILs group was significantly shorter than that in the low-TILs group (p = 0.012). In the ROC analysis, the AUC was 0.685. There were no significant differences between the percentages of the six kinetic patterns from the conventional DCE sequence and the TILs level (p = 0.075–0.876). Conclusion Compared to the low-TILs group, the high-TILs group had higher MS and shorter TTE.
Druh dokumentu: Article
Other literature type
Jazyk: English
ISSN: 1867-108X
1867-1071
DOI: 10.1007/s11604-024-01645-w
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39186213
https://repository.publisso.de/resource/frl:6517276
Rights: CC BY
Přístupové číslo: edsair.doi.dedup.....36565549c83ed2b892e6454b74f5b5b3
Databáze: OpenAIRE
Popis
Abstrakt:Purpose To evaluate the relationship between kinetic parameters of ultrafast dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and tumor-infiltrating lymphocytes (TILs) in breast cancer. Patients and methods This retrospective study was approved by an institutional review board and included 76 women (median age: 60) with 76 surgically proven breast cancers who underwent DCE MRI including ultrafast sequence. Based on the TILs level, we classified the patients into the low-TILs ( Results Of the 76 breast cancers, 57 were in the low-TILs group and 19 comprised the high-TILs group. The median MS in the high-TILs group (32.4%/sec) was significantly higher than that in the low-TILs group (23.68%/s) (p = 0.037). In a receiver-operating characteristic (ROC) analysis, the area under the curve (AUC) for differentiating between the high- and low-TILs group was 0.661. The TTE in the high-TILs group was significantly shorter than that in the low-TILs group (p = 0.012). In the ROC analysis, the AUC was 0.685. There were no significant differences between the percentages of the six kinetic patterns from the conventional DCE sequence and the TILs level (p = 0.075–0.876). Conclusion Compared to the low-TILs group, the high-TILs group had higher MS and shorter TTE.
ISSN:1867108X
18671071
DOI:10.1007/s11604-024-01645-w