Immunological and virological response to antiretroviral treatment in migrant and native men and women in Western Europe; is benefit equal for all?
Saved in:
| Title: | Immunological and virological response to antiretroviral treatment in migrant and native men and women in Western Europe; is benefit equal for all? |
|---|---|
| Authors: | Monge, S., Mocroft, A., Sabin, A., Touloumi, G., Sighem, A., Abgrall, S., Dray-Spira, R., Spire, B., Castagna, A., Mussini, C., Zangerle, R., Hessamfar, M., Anderson, J., Hamouda, O., Ehren, K., Obel, N., Kirk, O., Antinori, A., Girardi, E., Saracino, A., Calmy, A., Wit, S., Wittkop, L., Bucher, C., Montoliu, A., Raben, D., Prins, M., Meyer, L., Chene, G., Burns, F., Amo, J., Judd, Ali, Zangerle, Robert, Touloumi, Giota, Warszawski, Josiane, Meyer, Laurence, Dabis, François, Krause, Murielle, Ghosn, Jade, Leport, Catherine, Wittkop, Linda, Reiss, Peter, Wit, Ferdinand, Prins, Maria, Bucher, Heiner, Gibb, Diana, Fätkenheuer, Gerd, Amo, Julia, Obel, Niels, Thorne, Claire, Mocroft, Amanda, Kirk, Ole, Stephan, Christoph, Pérez-Hoyos, Santiago, Bartmeyer, Barbara, Chkhartishvili, Nikoloz, Noguera-Julian, Antoni, Antinori, Andrea, Monforte, Antonella, Brockmeyer, Norbert, Prieto, Luis, Conejo, Pablo, Soriano-Arandes, Antoni, Battegay, Manuel, Kouyos, Roger, Mussini, Cristina, Tookey, Pat, Casabona, Jordi, Miró, JoseM, Castagna, Antonella, Konopnick, Deborah, Goetghebuer, Tessa, Sönnerborg, Anders, Torti, Carlo, Sabin, Caroline, Teira, Ramon, Garrido, Myriam, Haerry, David, Wit, Stéphane, Miró, M., Costagliola, Dominique, d'Arminio-Monforte, Antonella, Raben, Dorthe, Chêne, Geneviève, Barger, Diana, Schwimmer, Christine, Termote, Monique, Campbell, Maria, Frederiksen, Casper M, Friis-Møller, Nina, Kjaer, Jesper, Brandt, Rikke, Berenguer, Juan, Bohlius, Julia, Bouteloup, Vincent, Cozzi-Lepri, Alessandro, Davies, Mary-Anne, Dorrucci, Maria, Dunn, David, Egger, Matthias, Furrer, Hansjakob, Guiguet, Marguerite, Grabar, Sophie, Lambotte, Olivier, Leroy, Valériane, Lodi, Sara, Matheron, Sophie, Miró, Jose, Monge, Susana, Nakagawa, Fumiyo, Paredes, Roger, Phillips, Andrew, Puoti, Massimo, Rohner, Eliane, Schomaker, Michael, Smit, Colette, Sterne, Jonathan, Thiebaut, Rodolphe, Valk, Marc |
| Contributors: | Monge, S., Mocroft, A., Sabin, A., Touloumi, G., Sighem, A., Abgrall, S., Dray-Spira, R., Spire, B., Castagna, A., Mussini, C., Zangerle, R., Hessamfar, M., Anderson, J., Hamouda, O., Ehren, K., Obel, N., Kirk, O., Antinori, A., Girardi, E., Saracino, A., Calmy, A., Wit, S., Wittkop, L., Bucher, C., Montoliu, A., Raben, D., Prins, M., Meyer, L., Chene, G., Burns, F., Amo, J., Judd, A., Warszawski, J., Dabis, F., Krause, M., Ghosn, J., Leport, C., Reiss, P., Wit, F., Bucher, H., Gibb, D., Fatkenheuer, G., Thorne, C., Stephan, C., Perez-Hoyos, S., Bartmeyer, B., Chkhartishvili, N., Noguera-Julian, A., Monforte, A., Brockmeyer, N., Prieto, L., Conejo, P., Soriano-Arandes, A., Battegay, M., Kouyos, R., Tookey, P., Casabona, J., Miro, J., Konopnick, D., Goetghebuer, T., Sonnerborg, A., Torti, C., Sabin, C., Teira, R., Garrido, M., Haerry, D., Miro, M., Costagliola, D., d'Arminio-Monforte, A., Barger, D., Schwimmer, C., Termote, M., Campbell, M., Frederiksen, C. M., Friis-Moller, N., Kjaer, J., Brandt, R., Berenguer, J., Bohlius, J., Bouteloup, V., Cozzi-Lepri, A., Davies, M. -A., Dorrucci, M., Dunn, D., Egger, M., Furrer, H., Guiguet, M., Grabar, S., Lambotte, O., Leroy, V., Lodi, S., Matheron, S., Nakagawa, F., Paredes, R., Phillips, A., Puoti, M., Rohner, E., Schomaker, M., Smit, C. |
| Source: | HIV Medicine, Vol. 19, No 1 (2018) pp. 42-48 |
| Publisher Information: | Wiley, 2017. |
| Publication Year: | 2017 |
| Subject Terms: | Combination antiretroviral therapy, Adult, Male, Adolescent, combination antiretroviral therapy, HIV, immunovirological response, migrants, sex, HIV Infections/drug therapy, HIV Infections, Anti-Retroviral Agents/therapeutic use, Cohort Studies, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Population Groups, Antiretroviral Therapy, Highly Active, Humans, Pharmacology (medical), Immunovirological response, RNA, Viral/blood, 10. No inequality, Aged, ddc:616, Transients and Migrants, Health Policy, Migrant, Middle Aged, Viral Load, 16. Peace & justice, Migrants, Sex, Infectious Diseases, CD4 Lymphocyte Count, 3. Good health, Europe, Treatment Outcome, Anti-Retroviral Agents, RNA, Viral, Female |
| Description: | ObjectivesThe aim of the study was to evaluate differences in immunovirological response to combination antiretroviral therapy (cART) in migrant and native men and women within a European collaboration of HIV cohorts Collaboration of Observational HIV Epidemiological Research in Europ (COHERE) in EuroCoord, 2004–2013.MethodsMigrants were defined as those with geographical origin (GO) different from the reporting country and were grouped as originating from Western Europe and Western Countries (WEWC), Eastern Europe (EE), North Africa and the Middle East (NAME), sub‐Saharan Africa (SSA), Latin America (LA), Caribbean (CRB) and Asia/Oceania (ASIA/OCE). Native (NAT) individuals were defined as those originating from the reporting country. CD4 cell counts were modelled using piecewise linear mixed‐effects models with two slopes, whereas models to estimate subdistribution hazard ratios (sHRs) were used for time to virological response (VR) (i.e. time from cART initiation to the first of two successive HIV RNA measurements < 400 HIV‐1 RNA copies/ml).ResultsOf 32 817 individuals, 25 799 (78.6%) were men. The percentage of migrants was higher in women (48.9%) than in men (21.2%) and migrants from SSA accounted for the largest migrant group (29.9% in men and 63.3% in women). Migrant men and women from SSA started at lower CD4 cell counts than NAT individuals, which remained lower over time. VR was ≥ 85% at 12 months for all groups except CRB women (77.7%). Compared with NAT men and women, lower VR was experienced by NAME [sHR 0.91; 95% confidence interval (CI) 0.86–0.97] and SSA (sHR 0.88; 95% CI 0.82–0.95) men and CRB (sHR 0.77; 85% CI 0.67–0.89) women, respectively.ConclusionsImmunovirological response to cART in Western Europe varies by GO and sex of patients. ART benefits are not equal for all, underlining the point that efforts need to prioritize those most in need. |
| Document Type: | Article |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 1468-1293 1464-2662 |
| DOI: | 10.1111/hiv.12536 |
| Access URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hiv.12536 https://pubmed.ncbi.nlm.nih.gov/28741837 http://dspace.library.uu.nl/handle/1874/366154 https://iris.unimore.it/handle/11380/1155074 https://ricerca.uniba.it/handle/11586/203430 https://moh-it.pure.elsevier.com/en/publications/immunological-and-virological-response-to-antiretroviral-treatmen https://boa.unimib.it/handle/10281/304402 https://core.ac.uk/display/132564143 http://www.wiley.com/bw/journal.asp?ref=1464-2662 https://hdl.handle.net/20.500.11768/68526 https://doi.org/10.1111/hiv.12536 https://pure.amsterdamumc.nl/en/publications/4fe266fa-671c-41b3-b806-a82b5d49b1dd https://doi.org/10.1111/hiv.12536 https://archive-ouverte.unige.ch/unige:115834 https://archive-ouverte.unige.ch/unige:115834 https://doi.org/10.1111/hiv.12536 http://www.wiley.com/bw/journal.asp?ref=1464-2662 https://doi.org/10.1111/hiv.12536 https://hdl.handle.net/11380/1155074 |
| Rights: | Wiley Online Library User Agreement |
| Accession Number: | edsair.doi.dedup.....33ebdfdad503b87df5dbad12f653ec20 |
| Database: | OpenAIRE |
Full Text Finder 
Nájsť tento článok vo Web of Science | Abstract: | ObjectivesThe aim of the study was to evaluate differences in immunovirological response to combination antiretroviral therapy (cART) in migrant and native men and women within a European collaboration of HIV cohorts Collaboration of Observational HIV Epidemiological Research in Europ (COHERE) in EuroCoord, 2004–2013.MethodsMigrants were defined as those with geographical origin (GO) different from the reporting country and were grouped as originating from Western Europe and Western Countries (WEWC), Eastern Europe (EE), North Africa and the Middle East (NAME), sub‐Saharan Africa (SSA), Latin America (LA), Caribbean (CRB) and Asia/Oceania (ASIA/OCE). Native (NAT) individuals were defined as those originating from the reporting country. CD4 cell counts were modelled using piecewise linear mixed‐effects models with two slopes, whereas models to estimate subdistribution hazard ratios (sHRs) were used for time to virological response (VR) (i.e. time from cART initiation to the first of two successive HIV RNA measurements < 400 HIV‐1 RNA copies/ml).ResultsOf 32 817 individuals, 25 799 (78.6%) were men. The percentage of migrants was higher in women (48.9%) than in men (21.2%) and migrants from SSA accounted for the largest migrant group (29.9% in men and 63.3% in women). Migrant men and women from SSA started at lower CD4 cell counts than NAT individuals, which remained lower over time. VR was ≥ 85% at 12 months for all groups except CRB women (77.7%). Compared with NAT men and women, lower VR was experienced by NAME [sHR 0.91; 95% confidence interval (CI) 0.86–0.97] and SSA (sHR 0.88; 95% CI 0.82–0.95) men and CRB (sHR 0.77; 85% CI 0.67–0.89) women, respectively.ConclusionsImmunovirological response to cART in Western Europe varies by GO and sex of patients. ART benefits are not equal for all, underlining the point that efforts need to prioritize those most in need. |
|---|---|
| ISSN: | 14681293 14642662 |
| DOI: | 10.1111/hiv.12536 |