Blunted coronary flow velocity reserve is associated with impairment in systolic function and functional capacity in hypertrophic cardiomyopathy
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| Titel: | Blunted coronary flow velocity reserve is associated with impairment in systolic function and functional capacity in hypertrophic cardiomyopathy |
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| Autoren: | Aguiar Rosa, S, Rocha Lopes, L, Branco, L, Galrinho, A, Fiarresga, A, Thomas, B, Brás, P, Gonçalves, A, Cardoso, I, Papoila, A, Alves, M, Rio, P, Cruz, I, Selas, M, Silva, F, Silva, A, Cruz Ferreira, R, Mota Carmo, M |
| Quelle: | International Journal of Cardiology. 359:61-68 |
| Verlagsinformationen: | Elsevier BV, 2022. |
| Publikationsjahr: | 2022 |
| Schlagwörter: | Male, Cardiomyopathy, Hypertrophic, HSM CAR, Coronary Vessels, Cardiomyopathy, Hypertrophic* / diagnostic imaging, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Coronary Circulation, Blood Flow Velocity / physiology, Coronary Circulation* / physiology, Humans, Female, Prospective Studies, Blood Flow Velocity |
| Beschreibung: | Coronary microvascular dysfunction constitutes an important pathophysiological feature in hypertrophic cardiomyopathy (HCM). We aimed to assess the association between impaired coronary flow velocity reserve (CFVR) and ventricular systolic function and functional capacity.Eighty-three patients with HCM were enrolled in this prospective cohort study. Patients underwent echocardiogram to evaluate ventricular performance and CFVR in the left anterior descending artery (LAD) and posterior descending artery (PD). Diastolic coronary flow velocity was measured in basal conditions and in hyperemia. CFVR was calculated as the ratio of hyperemic and basal peak diastolic flow velocities. Functional capacity was evaluated by cardiopulmonary exercise testing (CPET). The link between CFVR and biventricular systolic function and peak VO2 was studied.Age was 55.0(14.4)years, 50 patients (60%) were male; 59 patients (71%) had nonobstructive HCM. Mean CFVR LAD was 1.81(0.49) and CFVR PD was 1.73(0.55). Lower CFVR PD was associated with impaired global longitudinal strain (GLS) 2D (β-estimate:-3.240,95%CI:-4.634;-1.846, p |
| Publikationsart: | Article |
| Sprache: | English |
| ISSN: | 0167-5273 |
| DOI: | 10.1016/j.ijcard.2022.04.032 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/35427701 http://hdl.handle.net/10400.17/4102 |
| Rights: | Elsevier TDM |
| Dokumentencode: | edsair.doi.dedup.....33b0341150f97f194f442209a009c1dd |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Coronary microvascular dysfunction constitutes an important pathophysiological feature in hypertrophic cardiomyopathy (HCM). We aimed to assess the association between impaired coronary flow velocity reserve (CFVR) and ventricular systolic function and functional capacity.Eighty-three patients with HCM were enrolled in this prospective cohort study. Patients underwent echocardiogram to evaluate ventricular performance and CFVR in the left anterior descending artery (LAD) and posterior descending artery (PD). Diastolic coronary flow velocity was measured in basal conditions and in hyperemia. CFVR was calculated as the ratio of hyperemic and basal peak diastolic flow velocities. Functional capacity was evaluated by cardiopulmonary exercise testing (CPET). The link between CFVR and biventricular systolic function and peak VO2 was studied.Age was 55.0(14.4)years, 50 patients (60%) were male; 59 patients (71%) had nonobstructive HCM. Mean CFVR LAD was 1.81(0.49) and CFVR PD was 1.73(0.55). Lower CFVR PD was associated with impaired global longitudinal strain (GLS) 2D (β-estimate:-3.240,95%CI:-4.634;-1.846, p |
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| ISSN: | 01675273 |
| DOI: | 10.1016/j.ijcard.2022.04.032 |