Matrix metalloproteinase 9 (MMP-9) activity, hippocampal extracellular free water, and cognitive deficits are associated with each other in early phase psychosis
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| Název: | Matrix metalloproteinase 9 (MMP-9) activity, hippocampal extracellular free water, and cognitive deficits are associated with each other in early phase psychosis |
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| Autoři: | Johanna Seitz-Holland, Yasser Alemán-Gómez, Kang Ik K. Cho, Ofer Pasternak, Martine Cleusix, Raoul Jenni, Philipp S. Baumann, Paul Klauser, Philippe Conus, Patric Hagmann, Kim Q. Do, Marek Kubicki, Daniella Dwir |
| Zdroj: | Neuropsychopharmacology Neuropsychopharmacology, vol. 49, no. 7, pp. 1140-1150 |
| Informace o vydavateli: | Springer Science and Business Media LLC, 2024. |
| Rok vydání: | 2024 |
| Témata: | Male, Adult, 16. Peace & justice, Hippocampus, Magnetic Resonance Imaging, Article, 3. Good health, Young Adult, Humans, Matrix Metalloproteinase 9/blood, Matrix Metalloproteinase 9/metabolism, Hippocampus/diagnostic imaging, Hippocampus/pathology, Female, Psychotic Disorders/diagnostic imaging, Psychotic Disorders/pathology, Psychotic Disorders/physiopathology, Cognitive Dysfunction/diagnostic imaging, Cognitive Dysfunction/physiopathology, Cognitive Dysfunction/pathology, Diffusion Magnetic Resonance Imaging, Matrix Metalloproteinase 9, Psychotic Disorders, Cognitive Dysfunction |
| Popis: | Increasing evidence points toward the role of the extracellular matrix, specifically matrix metalloproteinase 9 (MMP-9), in the pathophysiology of psychosis. MMP-9 is a critical regulator of the crosstalk between peripheral and central inflammation, extracellular matrix remodeling, hippocampal development, synaptic pruning, and neuroplasticity. Here, we aim to characterize the relationship between plasma MMP-9 activity, hippocampal microstructure, and cognition in healthy individuals and individuals with early phase psychosis. We collected clinical, blood, and structural and diffusion-weighted magnetic resonance imaging data from 39 individuals with early phase psychosis and 44 age and sex-matched healthy individuals. We measured MMP-9 plasma activity, hippocampal extracellular free water (FW) levels, and hippocampal volumes. We used regression analyses to compare MMP-9 activity, hippocampal FW, and volumes between groups. We then examined associations between MMP-9 activity, FW levels, hippocampal volumes, and cognitive performance assessed with the MATRICS battery. All analyses were controlled for age, sex, body mass index, cigarette smoking, and years of education. Individuals with early phase psychosis demonstrated higher MMP-9 activity (p p p p p |
| Druh dokumentu: | Article Other literature type |
| Popis souboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1740-634X 0893-133X |
| DOI: | 10.1038/s41386-024-01814-5 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/38431757 https://serval.unil.ch/notice/serval:BIB_3DD3152D3A91 http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_3DD3152D3A912 https://serval.unil.ch/resource/serval:BIB_3DD3152D3A91.P001/REF.pdf |
| Rights: | CC BY |
| Přístupové číslo: | edsair.doi.dedup.....336a5f083784127699a0b75b7c17f383 |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Increasing evidence points toward the role of the extracellular matrix, specifically matrix metalloproteinase 9 (MMP-9), in the pathophysiology of psychosis. MMP-9 is a critical regulator of the crosstalk between peripheral and central inflammation, extracellular matrix remodeling, hippocampal development, synaptic pruning, and neuroplasticity. Here, we aim to characterize the relationship between plasma MMP-9 activity, hippocampal microstructure, and cognition in healthy individuals and individuals with early phase psychosis. We collected clinical, blood, and structural and diffusion-weighted magnetic resonance imaging data from 39 individuals with early phase psychosis and 44 age and sex-matched healthy individuals. We measured MMP-9 plasma activity, hippocampal extracellular free water (FW) levels, and hippocampal volumes. We used regression analyses to compare MMP-9 activity, hippocampal FW, and volumes between groups. We then examined associations between MMP-9 activity, FW levels, hippocampal volumes, and cognitive performance assessed with the MATRICS battery. All analyses were controlled for age, sex, body mass index, cigarette smoking, and years of education. Individuals with early phase psychosis demonstrated higher MMP-9 activity (p p p p p |
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| ISSN: | 1740634X 0893133X |
| DOI: | 10.1038/s41386-024-01814-5 |