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Visceral Fat Area Is an Independent Risk Factor for Overweight or Obese Nonalcoholic Fatty Liver Disease in Potential Living Liver Donors

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Title: Visceral Fat Area Is an Independent Risk Factor for Overweight or Obese Nonalcoholic Fatty Liver Disease in Potential Living Liver Donors
Authors: Sunyoung Lee, Kyoung Won Kim, Jeongjin Lee, Taeyong Park, Kyoyeong Koo, Gi-Won Song, Sung-Gyu Lee
Contributors: Sunyoung Lee, Kyoung Won Kim, Jeongjin Lee, Taeyong Park, Kyoyeong Koo, Gi-Won Song, Sung-Gyu Lee, Lee, Sunyoung
Source: Transplantation Proceedings. 54:702-705
Publisher Information: Elsevier BV, 2022.
Publication Year: 2022
Subject Terms: Adult, Male, 0301 basic medicine, Intra-Abdominal Fat, Body Mass Index, Young Adult, 03 medical and health sciences, Non-alcoholic Fatty Liver Disease, Risk Factors, Humans, Abdominal, Obesity, Intra-Abdominal Fat* / diagnostic imaging, Overweight / complications, Retrospective Studies, 2. Zero hunger, Non-alcoholic Fatty Liver Disease* / complications, 0303 health sciences, Liver / pathology, Overweight, Obesity / complications, Liver / diagnostic imaging, Liver, Non-alcoholic Fatty Liver Disease* / pathology, Obesity, Abdominal, Intra-Abdominal Fat* / pathology, Female
Description: The present study aimed to evaluate the correlation between hepatic steatosis (HS), determined by biopsy, and visceral adiposity, measured by computed tomography (CT), in overweight or obese potential living liver donors, and to investigate the risk factors for overweight or obese nonalcoholic fatty liver disease (NAFLD).This retrospective study included 375 overweight or obese (body mass index ≥23 kg/m2) potential living liver donors (mean age, 30.4 ± 9.5 years; 273 men) who underwent liver biopsies and abdominal CT examinations in 2017 and 2018. Anthropometry, laboratory parameters, body composition, and HS were assessed. Correlations were analyzed using Pearson's correlation coefficient, and logistic regression was used to identify independent predictors of overweight or obese NAFLD.Visceral fat area (VFA) was positively correlated with the degree of HS in men (r = 0.307; P < .001) and women (r = 0.387; P < .001). Multivariable logistic regression analysis showed that alanine aminotransferase (odds ratio [OR], 1.017; 95% confidence interval [CI], 1.001-1.033; P = .033) and VFA (OR, 1.015; 95% CI, 1.008-1.022; P < .001) were independent risk factors for overweight or obese NAFLD in men, and VFA (OR, 1.029; 95% CI, 1.011-1.047; P = .002) was an independent risk factor for overweight or obese NAFLD in women.Visceral adiposity was positively correlated with the degree of HS in overweight or obese potential living liver donors. Additionally, visceral adiposity may be an independent risk factor for overweight or obese NAFLD in potential living liver donors.
Document Type: Article
Language: English
ISSN: 0041-1345
DOI: 10.1016/j.transproceed.2021.10.032
Access URL: https://pubmed.ncbi.nlm.nih.gov/35256204
Rights: Elsevier TDM
CC BY NC ND
Accession Number: edsair.doi.dedup.....32e803384f460fc4439f4a16854a144e
Database: OpenAIRE
Description
Abstract:The present study aimed to evaluate the correlation between hepatic steatosis (HS), determined by biopsy, and visceral adiposity, measured by computed tomography (CT), in overweight or obese potential living liver donors, and to investigate the risk factors for overweight or obese nonalcoholic fatty liver disease (NAFLD).This retrospective study included 375 overweight or obese (body mass index ≥23 kg/m2) potential living liver donors (mean age, 30.4 ± 9.5 years; 273 men) who underwent liver biopsies and abdominal CT examinations in 2017 and 2018. Anthropometry, laboratory parameters, body composition, and HS were assessed. Correlations were analyzed using Pearson's correlation coefficient, and logistic regression was used to identify independent predictors of overweight or obese NAFLD.Visceral fat area (VFA) was positively correlated with the degree of HS in men (r = 0.307; P < .001) and women (r = 0.387; P < .001). Multivariable logistic regression analysis showed that alanine aminotransferase (odds ratio [OR], 1.017; 95% confidence interval [CI], 1.001-1.033; P = .033) and VFA (OR, 1.015; 95% CI, 1.008-1.022; P < .001) were independent risk factors for overweight or obese NAFLD in men, and VFA (OR, 1.029; 95% CI, 1.011-1.047; P = .002) was an independent risk factor for overweight or obese NAFLD in women.Visceral adiposity was positively correlated with the degree of HS in overweight or obese potential living liver donors. Additionally, visceral adiposity may be an independent risk factor for overweight or obese NAFLD in potential living liver donors.
ISSN:00411345
DOI:10.1016/j.transproceed.2021.10.032