Zobraziť v EDS

Identifying subphenotypes of patients undergoing post‐operative delirium assessment

Uložené v:
Podrobná bibliografia
Názov: Identifying subphenotypes of patients undergoing post‐operative delirium assessment
Autori: Bowman, EML, McAuley, DF, McGuinness, B, Passmore, AP, Beverland, D, Zetterberg, H, Schott, JM, Heslegrave, A, Veleva, E, Laban, R, Sweeney, A, Cunningham, EL
Zdroj: Alzheimers Dement
Bowman, E M L, McAuley, D F, McGuinness, B, Passmore, A P, Beverland, D, Zetterberg, H, Schott, J M, Heslegrave, A, Veleva, E, Laban, R, Sweeney, A & Cunningham, E L 2025, 'Identifying subphenotypes of patients undergoing post-operative delirium assessment', Alzheimer's & Dementia: The Journal of the Alzheimer's Association, vol. 21, no. 7, e70516. https://doi.org/10.1002/alz.70516
Informácie o vydavateľovi: Wiley, 2025.
Rok vydania: 2025
Predmety: phenotype, biomarkers/cerebrospinal fluid, tau proteins/cerebrospinal fluid, amyloid beta-peptides/cerebrospinal fluid, aged, female, delirium/diagnosis, male, cohort studies, latent class analysis, postoperative complications/diagnosis, humans, aged, 80 and over, Research Article
Popis: INTRODUCTIONDelirium has heterogeneous etiologies and clinical presentations and is often associated with poor outcomes. Its pathophysiological mechanisms remain largely hypothetical and without targeted pharmacological treatment. This work investigates subphenotypes of patients undergoing delirium assessment based on clinical features and fluid biomarkers.METHODSWe performed latent class analysis of an observational cohort of older adults undergoing elective surgery.RESULTSTwo classes were identified, both containing individuals experiencing delirium symptoms, with a higher number in Class 1 (p p p p p = 0.024); and amyloid beta 42/40 ratio (p p = 0.006) and received more morphine equivalents (p = 0.018).DISCUSSIONDelirium and neighboring phenotypes should be investigated thoroughly in the newly dawning era of precision medicine, to establish novel treatments.Highlights Latent class analysis identified two subphenotypes of patients. Both groups contained patients with delirium or its individual symptoms. Groups differed by age, education, depression, independent living, and pain levels. Groups differed by pre‐operative and post‐operative cognition. Groups differed by biomarker levels of neurodegeneration and neuronal injury.
Druh dokumentu: Article
Other literature type
Popis súboru: application/pdf
Jazyk: English
ISSN: 1552-5279
1552-5260
DOI: 10.1002/alz.70516
Prístupová URL adresa: https://pure.qub.ac.uk/en/publications/a8fc4e93-ae2a-4c59-82db-77fe2e118bdb
Rights: CC BY
Prístupové číslo: edsair.doi.dedup.....31bcba2a9ed7e7d1628ecc7228c641c1
Databáza: OpenAIRE
Popis
Abstrakt:INTRODUCTIONDelirium has heterogeneous etiologies and clinical presentations and is often associated with poor outcomes. Its pathophysiological mechanisms remain largely hypothetical and without targeted pharmacological treatment. This work investigates subphenotypes of patients undergoing delirium assessment based on clinical features and fluid biomarkers.METHODSWe performed latent class analysis of an observational cohort of older adults undergoing elective surgery.RESULTSTwo classes were identified, both containing individuals experiencing delirium symptoms, with a higher number in Class 1 (p p p p p = 0.024); and amyloid beta 42/40 ratio (p p = 0.006) and received more morphine equivalents (p = 0.018).DISCUSSIONDelirium and neighboring phenotypes should be investigated thoroughly in the newly dawning era of precision medicine, to establish novel treatments.Highlights Latent class analysis identified two subphenotypes of patients. Both groups contained patients with delirium or its individual symptoms. Groups differed by age, education, depression, independent living, and pain levels. Groups differed by pre‐operative and post‐operative cognition. Groups differed by biomarker levels of neurodegeneration and neuronal injury.
ISSN:15525279
15525260
DOI:10.1002/alz.70516