Evaluation of the 7th American Joint Committee on Cancer TNM Staging System for Prostate Cancer in Point of Classification of Bladder Neck Invasion
Uložené v:
| Názov: | Evaluation of the 7th American Joint Committee on Cancer TNM Staging System for Prostate Cancer in Point of Classification of Bladder Neck Invasion |
|---|---|
| Autori: | Dong Hoon Lee, Seung Hwan Lee, Byung Ha Chung, Mun Su Chung |
| Prispievatelia: | Mun Su Chung, Seung Hwan Lee, Dong Hoon Lee, Byung Ha Chung, Chung, Byung Ha, Lee, Dong Hoon, Lee, Seung Hwan |
| Zdroj: | Japanese Journal of Clinical Oncology. 43:184-188 |
| Informácie o vydavateľovi: | Oxford University Press (OUP), 2012. |
| Rok vydania: | 2012 |
| Predmety: | Asian Continental Ancestry Group, Male, Neoplasm, Residual, Prostate-Specific Antigen/blood, Urinary Bladder Neoplasms/pathology, Kaplan-Meier Estimate, Prostatic Neoplasms/immunology, prostatic neoplasms, Disease-Free Survival, Urinary Bladder Neoplasms/immunology, 03 medical and health sciences, Prostatic Neoplasms/pathology, 0302 clinical medicine, Asian People, Republic of Korea, 80 and over, Biomarkers, Tumor, Odds Ratio, Humans, Neoplasm Invasiveness, Prostatectomy, bladder, Aged, Neoplasm Staging, Proportional Hazards Models, Aged, 80 and over, Prostatic Neoplasms/surgery, prostatectomy, Prostatic Neoplasms, Reproducibility of Results, Prostate-Specific Antigen, 3. Good health, Urinary Bladder Neoplasms, Residual, Multivariate Analysis, Tumor/blood, Neoplasm, Biomarkers |
| Popis: | To assess the validity of the 7th edition of the American Joint Committee on Cancer TNM staging system for prostate cancer, paying special attention to bladder neck invasion, in an Asian population.Clinicopathologic data of 368 men who underwent radical prostatectomy between 2003 and 2011 at our institution were reviewed. The main interest of this study was to confirm that both isolated positive bladder neck margin and positive bladder neck margin associated with other surgical margin have more favorable biochemical outcomes than seminal vesicle invasion (pT3b).The 3-year biochemical recurrence-free survival for men with organ confined disease, extraprostatic extension, isolated positive bladder neck margin, positive bladder neck margin with other surgical margin and seminal vesicle invasion was 88.9, 74.8, 51.2, 19.4 and 18.8%, respectively. On multivariate analysis, the increased risk of progression associated with an isolated positive bladder neck margin (hazard ratio 4.34, 95% confidence interval 1.40-13.46, P = 0.011) was less than that of seminal vesicle invasion (hazard ratio 9.67, 95% confidence interval 3.70-25.25, P < 0.001). As for the positive bladder neck margin with other surgical margin, the increased risk of progression (hazard ratio 9.32, 95% confidence interval 3.50-24.82, P < 0.001) was similar to that of men with seminal vesicle invasion.In our study, men with isolated positive bladder neck margin and positive bladder neck margin plus other surgical margin had no worse biochemical outcomes than those with seminal vesicle invasion (pT3b). It is reasonable to classify prostate cancer with bladder neck invasion (the 6th American Joint Committee on Cancer edition pT4 category) into the 7th edition pT3 category. |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 1465-3621 0368-2811 |
| DOI: | 10.1093/jjco/hys196 |
| Prístupová URL adresa: | https://academic.oup.com/jjco/article-pdf/43/2/184/11658841/hys196.pdf https://pubmed.ncbi.nlm.nih.gov/23225909 http://jjco.oxfordjournals.org/content/43/2/184.full https://academic.oup.com/jjco/article/43/2/184/876465 https://www.ncbi.nlm.nih.gov/pubmed/23225909 https://yonsei.pure.elsevier.com/en/publications/evaluation-of-the-7th-american-joint-committee-on-cancer-tnm-stag https://ir.ymlib.yonsei.ac.kr/handle/22282913/86415 https://ir.ymlib.yonsei.ac.kr/bitstream/22282913/86415/1/T201300379.pdf |
| Rights: | CC BY NC ND |
| Prístupové číslo: | edsair.doi.dedup.....3110c7462b1d88358ab03a5566500eb0 |
| Databáza: | OpenAIRE |
Full Text Finder 
Nájsť tento článok vo Web of Science | Abstrakt: | To assess the validity of the 7th edition of the American Joint Committee on Cancer TNM staging system for prostate cancer, paying special attention to bladder neck invasion, in an Asian population.Clinicopathologic data of 368 men who underwent radical prostatectomy between 2003 and 2011 at our institution were reviewed. The main interest of this study was to confirm that both isolated positive bladder neck margin and positive bladder neck margin associated with other surgical margin have more favorable biochemical outcomes than seminal vesicle invasion (pT3b).The 3-year biochemical recurrence-free survival for men with organ confined disease, extraprostatic extension, isolated positive bladder neck margin, positive bladder neck margin with other surgical margin and seminal vesicle invasion was 88.9, 74.8, 51.2, 19.4 and 18.8%, respectively. On multivariate analysis, the increased risk of progression associated with an isolated positive bladder neck margin (hazard ratio 4.34, 95% confidence interval 1.40-13.46, P = 0.011) was less than that of seminal vesicle invasion (hazard ratio 9.67, 95% confidence interval 3.70-25.25, P < 0.001). As for the positive bladder neck margin with other surgical margin, the increased risk of progression (hazard ratio 9.32, 95% confidence interval 3.50-24.82, P < 0.001) was similar to that of men with seminal vesicle invasion.In our study, men with isolated positive bladder neck margin and positive bladder neck margin plus other surgical margin had no worse biochemical outcomes than those with seminal vesicle invasion (pT3b). It is reasonable to classify prostate cancer with bladder neck invasion (the 6th American Joint Committee on Cancer edition pT4 category) into the 7th edition pT3 category. |
|---|---|
| ISSN: | 14653621 03682811 |
| DOI: | 10.1093/jjco/hys196 |