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Associations of Depressive and Anxiety Disorders with Pulmonary Disorders in the Community: The PneumoLaus and PsyCoLaus Studies

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Title: Associations of Depressive and Anxiety Disorders with Pulmonary Disorders in the Community: The PneumoLaus and PsyCoLaus Studies
Authors: Touilloux, B., Casutt, A., Strippoli, M.F., Lenoir, A., Janett, S., Vollenweider, P., Vaucher, J., Nicod, L., Preisig, M., Von Garnier, C.
Source: Respiration
Respiration; international review of thoracic diseases, vol. 103, no. 8, pp. 503-512
Publisher Information: S. Karger AG, 2024.
Publication Year: 2024
Subject Terms: Male, Depressive Disorder, Major, Comorbidity, Humans, Female, Middle Aged, Anxiety Disorders/epidemiology, Aged, Switzerland/epidemiology, Pulmonary Disease, Chronic Obstructive/epidemiology, Pulmonary Disease, Chronic Obstructive/psychology, Pulmonary Disease, Chronic Obstructive/complications, Pulmonary Disease, Chronic Obstructive/physiopathology, Asthma/epidemiology, Asthma/complications, Asthma/psychology, Depressive Disorder, Major/epidemiology, Depressive Disorder, Major/complications, Spirometry, Cross-Sectional Studies, Cohort Studies, Anxiety disorders, Asthma, Chronic obstructive pulmonary disease, Depression, Lung function, Anxiety Disorders, Pulmonary Disease, Chronic Obstructive, 03 medical and health sciences, 0302 clinical medicine, Basic Science Investigations, Switzerland
Description: Introduction: Mental health disorders figure among the many comorbidities of obstructive respiratory diseases. The multisystemic characteristics of chronic respiratory disease and its impact on quality of life could affect depressive and/or anxiety disorders. We aimed to evaluate the association of spirometric indices, ventilatory disorders, and self-reported respiratory diseases with psychiatric disorders considering potential confounders. Methods: We analysed data from CoLaus|PsyCoLaus, a Swiss population-based cohort study, consisting of 2’774 participants (56% women; mean age: 62.3 (standard deviation = ±9.9) years) who performed spirometry and completed semi-structured psychiatric interviews. We defined ventilatory disorders using GLI-2012 references. Major depressive episode (MDE) and anxiety disorders were defined using the DSM-IV (Diagnostic and Statistical Manual). Results: 630 subjects (22.7%) presented a recent MDE. Reversible obstructive ventilatory disorders were associated with recent MDE (OR = 1.94, 95% confidence interval (95% CI) 1.10–3.43) and recent anxiety disorders (2.21 [1.16–4.22]) only in unadjusted model. Self-reported chronic obstructive pulmonary (COPD) and asthma were associated with MDE with ORs of 2.49 (95% CI, 1.19–5.27) and 1.56 (95% CI, 1.04–2.35) after adjustment, respectively. Possible restrictive ventilatory impairment was positively associated with recent anxiety disorders (OR = 2.46, 1.10–5.51). Z-scores of FEV1, FVC, and maximal mid-expiratory flow were not associated with psychiatric disorders. There was no association between ventilatory disorders and MDE in adjusted models. Conclusions: In this cross-sectional population-based study, the association between respiratory disorders and depressive disorders was observed for self-reported COPD and asthma, but not with objective diagnoses based on spirometry. Lung volumes are not associated with psychiatric disorders. Further prospective studies will be necessary to understand the significance of the association.
Document Type: Article
Other literature type
File Description: application/pdf
Language: English
ISSN: 1423-0356
0025-7931
DOI: 10.1159/000537918
Access URL: https://pubmed.ncbi.nlm.nih.gov/38417406
https://serval.unil.ch/notice/serval:BIB_2768E4F2E465
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http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_2768E4F2E4651
Rights: CC BY NC
URL: http://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
Accession Number: edsair.doi.dedup.....2f050abe7246a11e2926f5bef6a465f8
Database: OpenAIRE
Description
Abstract:Introduction: Mental health disorders figure among the many comorbidities of obstructive respiratory diseases. The multisystemic characteristics of chronic respiratory disease and its impact on quality of life could affect depressive and/or anxiety disorders. We aimed to evaluate the association of spirometric indices, ventilatory disorders, and self-reported respiratory diseases with psychiatric disorders considering potential confounders. Methods: We analysed data from CoLaus|PsyCoLaus, a Swiss population-based cohort study, consisting of 2’774 participants (56% women; mean age: 62.3 (standard deviation = ±9.9) years) who performed spirometry and completed semi-structured psychiatric interviews. We defined ventilatory disorders using GLI-2012 references. Major depressive episode (MDE) and anxiety disorders were defined using the DSM-IV (Diagnostic and Statistical Manual). Results: 630 subjects (22.7%) presented a recent MDE. Reversible obstructive ventilatory disorders were associated with recent MDE (OR = 1.94, 95% confidence interval (95% CI) 1.10–3.43) and recent anxiety disorders (2.21 [1.16–4.22]) only in unadjusted model. Self-reported chronic obstructive pulmonary (COPD) and asthma were associated with MDE with ORs of 2.49 (95% CI, 1.19–5.27) and 1.56 (95% CI, 1.04–2.35) after adjustment, respectively. Possible restrictive ventilatory impairment was positively associated with recent anxiety disorders (OR = 2.46, 1.10–5.51). Z-scores of FEV1, FVC, and maximal mid-expiratory flow were not associated with psychiatric disorders. There was no association between ventilatory disorders and MDE in adjusted models. Conclusions: In this cross-sectional population-based study, the association between respiratory disorders and depressive disorders was observed for self-reported COPD and asthma, but not with objective diagnoses based on spirometry. Lung volumes are not associated with psychiatric disorders. Further prospective studies will be necessary to understand the significance of the association.
ISSN:14230356
00257931
DOI:10.1159/000537918