Fabrication and Characterization of Bioactive Gelatin–Alginate–Bioactive Glass Composite Coatings on Porous Titanium Substrates
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| Title: | Fabrication and Characterization of Bioactive Gelatin–Alginate–Bioactive Glass Composite Coatings on Porous Titanium Substrates |
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| Authors: | Belen Begines, Cristina Arevalo, Carlos Romero, Zoya Hadzhieva, Aldo R. Boccaccini, Yadir Torres |
| Contributors: | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica, Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte |
| Source: | ACS Appl Mater Interfaces idUS. Depósito de Investigación de la Universidad de Sevilla instname Universidad de Sevilla (US) |
| Publisher Information: | American Chemical Society (ACS), 2022. |
| Publication Year: | 2022 |
| Subject Terms: | biopolymer composites, Titanium, 0301 basic medicine, tribomechanical behavior, Alginates, bioactive coating, Prostheses and Implants, 02 engineering and technology, porous titanium, 03 medical and health sciences, osteochondral defects, Gelatin, Glass, 0210 nano-technology, Porosity |
| Description: | In this research work, the fabrication of biphasic composite implants has been investigated. Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues. The microstructure, degradation rates, biofunctionality, and wear behavior of the different composites were analyzed to find the best possible coating. Experiments demonstrated the best micromechanical balance for the substrate containing 200-355 μm size range distribution. In addition, although the coating prepared from alginate presented a lower mass loss, the composite containing 50% alginate and 50% gelatin showed a higher elastic recovery, which entails that this type of coating could replicate the functions of the soft tissue in areas of the joints. Therefore, results revealed that the combinations of porous commercially pure Ti and composites prepared from alginate/gelatin/45S5 BG are candidates for the fabrication of biphasic implants not only for the treatment of osteochondral defects but also potentially for any other diseases affecting simultaneously hard and soft tissues. |
| Document Type: | Article Other literature type |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.2c01241 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/35316017 https://idus.us.es/handle//11441/132206 https://hdl.handle.net/11441/132206 |
| Rights: | CC BY CC BY NC ND URL: http://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (http://creativecommons.org/licenses/by/4.0/). |
| Accession Number: | edsair.doi.dedup.....2e234b31465e86e9683d3c2d1d66bf88 |
| Database: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstract: | In this research work, the fabrication of biphasic composite implants has been investigated. Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues. The microstructure, degradation rates, biofunctionality, and wear behavior of the different composites were analyzed to find the best possible coating. Experiments demonstrated the best micromechanical balance for the substrate containing 200-355 μm size range distribution. In addition, although the coating prepared from alginate presented a lower mass loss, the composite containing 50% alginate and 50% gelatin showed a higher elastic recovery, which entails that this type of coating could replicate the functions of the soft tissue in areas of the joints. Therefore, results revealed that the combinations of porous commercially pure Ti and composites prepared from alginate/gelatin/45S5 BG are candidates for the fabrication of biphasic implants not only for the treatment of osteochondral defects but also potentially for any other diseases affecting simultaneously hard and soft tissues. |
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| ISSN: | 19448252 19448244 |
| DOI: | 10.1021/acsami.2c01241 |