Luminal matrices: An inside view on organ morphogenesis
Uloženo v:
| Název: | Luminal matrices: An inside view on organ morphogenesis |
|---|---|
| Autoři: | Luschnig Stefan, Uv Anne |
| Přispěvatelé: | University of Zurich |
| Zdroj: | EXPERIMENTAL CELL RESEARCH Experimental Cell Research |
| Informace o vydavateli: | Elsevier BV, 2014. |
| Rok vydání: | 2014 |
| Témata: | 0301 basic medicine, 0303 health sciences, Organogenesis, Chitin, Apical extracellular matrix, Tubulogenesis, 10124 Institute of Molecular Life Sciences, Extracellular Matrix, 1307 Cell Biology, 03 medical and health sciences, Luminal pressure, Lumen, 570 Life sciences, biology, Animals, Drosophila Proteins, Drosophila, Mechanical forces |
| Popis: | Tubular epithelia come in various shapes and sizes to accommodate the specific needs for transport, excretion and absorption in multicellular organisms. The intestinal tract, glandular organs and conduits for liquids and gases are all lined by a continuous layer of epithelial cells, which form the boundary of the luminal space. Defects in epithelial architecture and lumen dimensions will impair transport and can lead to serious organ malfunctions. Not surprisingly, multiple cellular and molecular mechanisms contribute to the shape of tubular epithelial structures. One intriguing aspect of epithelial organ formation is the highly coordinate behavior of individual cells as they mold the mature lumen. Here, we focus on recent findings, primarily from Drosophila, demonstrating that informative cues can emanate from the developing organ lumen in the form of solid luminal material. The luminal material is produced by the surrounding epithelium and helps to coordinate changes in shape and arrangement of the very same cells, resulting in correct lumen dimensions. |
| Druh dokumentu: | Article Other literature type |
| Popis souboru: | Luschnig_Uv_ECR_2013_accepted_ms.pdf - application/pdf |
| Jazyk: | English |
| ISSN: | 0014-4827 |
| DOI: | 10.1016/j.yexcr.2013.09.010 |
| DOI: | 10.5167/uzh-81590 |
| Přístupová URL adresa: | https://www.zora.uzh.ch/id/eprint/81590/1/Luschnig_Uv_ECR_2013_accepted_ms.pdf https://pubmed.ncbi.nlm.nih.gov/24075963 https://www.zora.uzh.ch/id/eprint/81590/1/Luschnig_Uv_ECR_2013_accepted_ms.pdf https://pubmed.ncbi.nlm.nih.gov/24075963/ http://www.sciencedirect.com/science/article/pii/S0014482713003935 https://www.sciencedirect.com/science/article/pii/S0014482713003935 https://europepmc.org/article/MED/24075963 https://www.ncbi.nlm.nih.gov/pubmed/24075963 https://www.zora.uzh.ch/id/eprint/81590/ https://doi.org/10.5167/uzh-81590 http://www.sciencedirect.com/science/article/pii/S0014482713003935 |
| Rights: | Elsevier TDM |
| Přístupové číslo: | edsair.doi.dedup.....2cd2de289d3a84f569eea10f5094c88a |
| Databáze: | OpenAIRE |
Full Text Finder 
Nájsť tento článok vo Web of Science | Abstrakt: | Tubular epithelia come in various shapes and sizes to accommodate the specific needs for transport, excretion and absorption in multicellular organisms. The intestinal tract, glandular organs and conduits for liquids and gases are all lined by a continuous layer of epithelial cells, which form the boundary of the luminal space. Defects in epithelial architecture and lumen dimensions will impair transport and can lead to serious organ malfunctions. Not surprisingly, multiple cellular and molecular mechanisms contribute to the shape of tubular epithelial structures. One intriguing aspect of epithelial organ formation is the highly coordinate behavior of individual cells as they mold the mature lumen. Here, we focus on recent findings, primarily from Drosophila, demonstrating that informative cues can emanate from the developing organ lumen in the form of solid luminal material. The luminal material is produced by the surrounding epithelium and helps to coordinate changes in shape and arrangement of the very same cells, resulting in correct lumen dimensions. |
|---|---|
| ISSN: | 00144827 |
| DOI: | 10.1016/j.yexcr.2013.09.010 |