Periodontitis and pulmonary function: a Mendelian randomization study
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| Názov: | Periodontitis and pulmonary function: a Mendelian randomization study |
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| Autori: | Sven Gläser, Michael Nolde, Sebastian-Edgar Baumeister, Birte Holtfreter, Benjamin Ehmke, Hansjörg Baurecht, Thomas Kocher |
| Zdroj: | Clin Oral Investig |
| Informácie o vydavateľovi: | Springer Science and Business Media LLC, 2021. |
| Rok vydania: | 2021 |
| Predmety: | 0301 basic medicine, ddc:610, 0303 health sciences, Short Communication, 610 Medizin, Mendelian Randomization Analysis, Polymorphism, Single Nucleotide, HEALTH, Periodontitis, Lung function, Mendelian randomization, 3. Good health, 03 medical and health sciences, Humans, Polymorphism, Single Nucleotide [MeSH], Humans [MeSH], Mendelian Randomization Analysis [MeSH], Periodontitis/genetics [MeSH], Lung [MeSH], Genome-Wide Association Study [MeSH], Lung, Genome-Wide Association Study |
| Popis: | Objectives Observational research suggests that periodontitis affects pulmonary function; however, observational studies are subject to confounding and reverse causation, making causal inference and the direction of these associations difficult. We used Mendelian randomization (MR) to assess the potential causal association between genetic liability to periodontitis and pulmonary function. Materials and methods We used six single-nucleotide polymorphisms (SNPs) associated with periodontitis (P −6) from a genome-wide association study (GWAS) of 17,353 European descent periodontitis cases and 28,210 controls from the GeneLifestyle Interactions in Dental Endpoints consortium and the UK Biobank, and related these to SNPs from a lung function GWAS including 79,055 study participants of the SpiroMeta Consortium. Results MR analysis suggested no effect of periodontitis on the ratio of forced expiratory volume in one second to lower forced vital capacity (standard deviation increment in outcome per doubling of the odds of the exposure (95% confidence interval) = − 0.004 (− 0.028; 0.020)). Replication analysis using genetic instruments from two different GWAS and sensitivity analyses to address potential pleiotropy led to no substantial changes in estimates. Conclusions Collectively, these findings do not support a relationship between genetic liability for periodontitis and pulmonary function. Clinical relevance Periodontitis does not seem to be a risk factor for worsening of pulmonary function. |
| Druh dokumentu: | Article Other literature type |
| Popis súboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1436-3771 1432-6981 |
| DOI: | 10.1007/s00784-021-04000-9 |
| DOI: | 10.5283/epub.56482 |
| DOI: | 10.5283/epub.5648210.1007/s00784-021-04000-9 |
| Prístupová URL adresa: | https://link.springer.com/content/pdf/10.1007/s00784-021-04000-9.pdf https://pubmed.ncbi.nlm.nih.gov/34046741 https://www.ncbi.nlm.nih.gov/pubmed/34046741 https://link.springer.com/content/pdf/10.1007/s00784-021-04000-9.pdf https://europepmc.org/article/MED/34046741 https://link.springer.com/article/10.1007/s00784-021-04000-9 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342344 https://pubmed.ncbi.nlm.nih.gov/34046741/ https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/87357 https://doi.org/10.1007/s00784-021-04000-9 https://opus.bibliothek.uni-augsburg.de/opus4/files/87357/Baumeister2021_Article_PeriodontitisAndPulmonaryFunct.pdf https://nbn-resolving.org/urn:nbn:de:bvb:384-opus4-873574 https://repository.publisso.de/resource/frl:6449190 https://epub.uni-regensburg.de/56482/ |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) . |
| Prístupové číslo: | edsair.doi.dedup.....2b46a7c8ea18009ca83bc59ad783bf92 |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Objectives Observational research suggests that periodontitis affects pulmonary function; however, observational studies are subject to confounding and reverse causation, making causal inference and the direction of these associations difficult. We used Mendelian randomization (MR) to assess the potential causal association between genetic liability to periodontitis and pulmonary function. Materials and methods We used six single-nucleotide polymorphisms (SNPs) associated with periodontitis (P −6) from a genome-wide association study (GWAS) of 17,353 European descent periodontitis cases and 28,210 controls from the GeneLifestyle Interactions in Dental Endpoints consortium and the UK Biobank, and related these to SNPs from a lung function GWAS including 79,055 study participants of the SpiroMeta Consortium. Results MR analysis suggested no effect of periodontitis on the ratio of forced expiratory volume in one second to lower forced vital capacity (standard deviation increment in outcome per doubling of the odds of the exposure (95% confidence interval) = − 0.004 (− 0.028; 0.020)). Replication analysis using genetic instruments from two different GWAS and sensitivity analyses to address potential pleiotropy led to no substantial changes in estimates. Conclusions Collectively, these findings do not support a relationship between genetic liability for periodontitis and pulmonary function. Clinical relevance Periodontitis does not seem to be a risk factor for worsening of pulmonary function. |
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| ISSN: | 14363771 14326981 |
| DOI: | 10.1007/s00784-021-04000-9 |