Regional specialization of movement encoding across the primate sensorimotor cortex
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| Názov: | Regional specialization of movement encoding across the primate sensorimotor cortex |
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| Autori: | Simon Borgognon, Nicolò Macellari, Alexandra M. Hickey, Matthew G. Perich, Houman Javaheri, Rafael Ornelas-Kobayashi, Maude Delacombaz, Christopher Hitz, Florian Fallegger, Stéphanie P. Lacour, Erwan Bezard, Eric M. Rouiller, Jocelyne Bloch, Tomislav Milekovic, Ismael Seáñez, Grégoire Courtine |
| Zdroj: | Nat Commun Nature communications, vol. 16, no. 1, pp. 5729 Nature Communications, 16 (1) |
| Informácie o vydavateľovi: | Springer Science and Business Media LLC, 2025. |
| Rok vydania: | 2025 |
| Predmety: | Motor cortex, Premotor cortex, Animals, Motor Cortex/physiology, Movement/physiology, Male, Sensorimotor Cortex/physiology, Somatosensory Cortex/physiology, Macaca mulatta/physiology, Female, Neurons/physiology, Article |
| Popis: | The process by which the cerebral cortex generates movements to achieve different tasks remains poorly understood. Here, we leveraged the rich repertoire of well-controlled primate locomotor behaviors to study how task-specific movements are encoded across the dorsal premotor cortex (PMd), primary motor cortex (M1), and primary somatosensory cortex (S1) under naturalistic conditions. Neural population activity was confined within low-dimensional manifolds and partitioned into task-dependent and task-independent subspaces. However, the prevalence of these subspaces differed between cortical regions. PMd primarily operated within its task-dependent subspace, while S1, and to a lesser extent M1, largely evolved within their task-independent subspaces. The temporal structure of movement was encoded in the task-independent subspaces, which also dominated the PMd-to-M1 communication as the movement plans were translated into motor commands. Our results suggest that the brain utilizes different cortical regions to serialize the motor control by first performing task-specific computations in PMd to then generate task-independent commands in M1. |
| Druh dokumentu: | Article Other literature type |
| Popis súboru: | application/pdf; application/application/pdf |
| Jazyk: | English |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-025-61172-8 |
| DOI: | 10.3929/ethz-b-000745218 |
| Prístupová URL adresa: | https://serval.unil.ch/notice/serval:BIB_87F23DE32CFA https://serval.unil.ch/resource/serval:BIB_87F23DE32CFA.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_87F23DE32CFA4 http://hdl.handle.net/20.500.11850/745218 |
| Rights: | CC BY |
| Prístupové číslo: | edsair.doi.dedup.....2b0d562699c7f60f36e0fc8d83758efe |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | The process by which the cerebral cortex generates movements to achieve different tasks remains poorly understood. Here, we leveraged the rich repertoire of well-controlled primate locomotor behaviors to study how task-specific movements are encoded across the dorsal premotor cortex (PMd), primary motor cortex (M1), and primary somatosensory cortex (S1) under naturalistic conditions. Neural population activity was confined within low-dimensional manifolds and partitioned into task-dependent and task-independent subspaces. However, the prevalence of these subspaces differed between cortical regions. PMd primarily operated within its task-dependent subspace, while S1, and to a lesser extent M1, largely evolved within their task-independent subspaces. The temporal structure of movement was encoded in the task-independent subspaces, which also dominated the PMd-to-M1 communication as the movement plans were translated into motor commands. Our results suggest that the brain utilizes different cortical regions to serialize the motor control by first performing task-specific computations in PMd to then generate task-independent commands in M1. |
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| ISSN: | 20411723 |
| DOI: | 10.1038/s41467-025-61172-8 |