Prevalence and risk factors of hypothalamic–pituitary dysfunction in infant and toddler childhood brain tumor survivors
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| Název: | Prevalence and risk factors of hypothalamic–pituitary dysfunction in infant and toddler childhood brain tumor survivors |
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| Autoři: | A. Y. N. Schouten-van Meeteren, William P. Vandertop, S.C. Clement, Geert O. Janssens, A S P van Trotsenburg, Chantal A Lebbink, L van Iersel, T P Ringers, H.M. van Santen, A M Boot, Erna M.C. Michiels, K S Han, D G van Vuurden, H.L. Claahsen-van der Grinten, L. C. M. Kremer |
| Přispěvatelé: | Endocrinologie onderzoek, Child Health, MS Radiotherapie, Cancer, KinderComfortTeam, Neurochirurgen, Zorg en O&O, Endocrinologie patientenzorg, Brain |
| Zdroj: | Lebbink, C A, Ringers, T P, Schouten-van Meeteren, A Y N, van Iersel, L, Clement, S C, Boot, A M, Claahsen-van der Grinten, H L, Janssens, G O, van Vuurden, D G, Michiels, E M, Han, K S, van Trotsenburg, A S P, Vandertop, W P, Kremer, L C M & van Santen, H M 2021, 'Prevalence and risk factors of hypothalamic-pituitary dysfunction in infant and toddler childhood brain tumor survivors', European Journal of Endocrinology, vol. 185, no. 4, pp. 597-606. https://doi.org/10.1530/EJE-21-0137 European Journal of Endocrinology, 185, 4, pp. 597-606 |
| Informace o vydavateli: | Oxford University Press (OUP), 2021. |
| Rok vydání: | 2021 |
| Témata: | Adult, Male, Adolescent, Pituitary Diseases, Netherlands/epidemiology, Pituitary Diseases/epidemiology, Cohort Studies, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Cancer Survivors, Risk Factors, Hypothalamic Diseases/epidemiology, Journal Article, Prevalence, Humans, Paediatrics - Radboud University Medical Center, Age of Onset, Child, Netherlands, Retrospective Studies, Radboudumc 16: Vascular damage RIMLS: Radboud Institute for Molecular Life Sciences, Brain Neoplasms, Infant, 3. Good health, Brain Neoplasms/complications, Child, Preschool, Female, Hypothalamic Diseases, Cancer Survivors/statistics & numerical data, Follow-Up Studies |
| Popis: | Objective Childhood brain tumor survivors (CBTS) are at risk to develop hypothalamic–pituitary (HP) dysfunction (HPD). The risk for HPD may vary between different age groups due to maturation of the brain and differences in oncologic treatment protocols. Specific studies on HPD in infant brain tumor survivors (infant-BTS, 0–1 years at diagnosis) or toddler brain tumor survivors (toddler-BTS, ≥1–3 years) have not been performed. Patients and methods A retrospective nationwide cohort study in CBTS was performed. Prevalence and risk factors for HPD were compared between infant-, toddler-, and older-BTS. Subgroup analysis was performed for all non-irradiated CBTS (n = 460). Results In total, 718 CBTS were included, with a median follow-up time of 7.9 years. Overall, despite the less frequent use of radiotherapy (RT) in infants, no differences in the prevalence of HPD were found between the three groups. RT (OR: 16.44; 95% CI: 8.93–30.27), suprasellar tumor location (OR: 44.76; 95% CI: 19.00–105.49), and younger age (OR: 1.11; 95% CI: 1.05–1.18) were associated with HP dysfunction. Infant-BTS and toddler-BTS showed more weight gain (P < 0.0001) and smaller height SDS (P = 0.001) during follow-up. In non-irradiated CBTS, infant-BTS and toddler-BTS were significantly more frequently diagnosed with TSH-, ACTH-, and ADH deficiency, compared to older-BTS. Conclusion Infant and toddler brain tumor survivors seem to be more vulnerable to develop HP dysfunction than older children. These results emphasize the importance of special infant and toddler brain tumor treatment protocols and the need for endocrine surveillance in children treated for a brain tumor at a young age. |
| Druh dokumentu: | Article |
| Popis souboru: | application/pdf |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/eje-21-0137 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/34324432 https://hdl.handle.net/11370/20effda1-2fe3-453e-8b99-625da0cb726e https://doi.org/10.1530/EJE-21-0137 https://research.rug.nl/en/publications/20effda1-2fe3-453e-8b99-625da0cb726e https://www.ncbi.nlm.nih.gov/pubmed/34324432 https://research.vumc.nl/en/publications/prevalence-and-risk-factors-of-hypothalamic-pituitary-dysfunction https://pubmed.ncbi.nlm.nih.gov/34324432/ https://researchinformation.amsterdamumc.org/en/publications/prevalence-and-risk-factors-of-hypothalamic-pituitary-dysfunction-2 https://eje.bioscientifica.com/view/journals/eje/185/4/EJE-21-0137.xml https://www.narcis.nl/publication/RecordID/oai%3Apure.atira.dk%3Apublications%2F33d3de6d-52da-43c0-8000-3bdcb269893c https://research.vumc.nl/en/publications/94679db0-26e1-45d9-8c8d-d8ed8477ca1f https://dspace.library.uu.nl/handle/1874/443824 https://pure.amsterdamumc.nl/en/publications/1ea8384f-b651-4eae-a0aa-3bea0cba1259 https://doi.org/10.1530/EJE-21-0137 https://repository.ubn.ru.nl//bitstream/handle/2066/237497/237497.pdf https://hdl.handle.net/2066/237497 |
| Rights: | taverne CC BY |
| Přístupové číslo: | edsair.doi.dedup.....2a3cad39d8ca56584de7d69171243741 |
| Databáze: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstrakt: | Objective Childhood brain tumor survivors (CBTS) are at risk to develop hypothalamic–pituitary (HP) dysfunction (HPD). The risk for HPD may vary between different age groups due to maturation of the brain and differences in oncologic treatment protocols. Specific studies on HPD in infant brain tumor survivors (infant-BTS, 0–1 years at diagnosis) or toddler brain tumor survivors (toddler-BTS, ≥1–3 years) have not been performed. Patients and methods A retrospective nationwide cohort study in CBTS was performed. Prevalence and risk factors for HPD were compared between infant-, toddler-, and older-BTS. Subgroup analysis was performed for all non-irradiated CBTS (n = 460). Results In total, 718 CBTS were included, with a median follow-up time of 7.9 years. Overall, despite the less frequent use of radiotherapy (RT) in infants, no differences in the prevalence of HPD were found between the three groups. RT (OR: 16.44; 95% CI: 8.93–30.27), suprasellar tumor location (OR: 44.76; 95% CI: 19.00–105.49), and younger age (OR: 1.11; 95% CI: 1.05–1.18) were associated with HP dysfunction. Infant-BTS and toddler-BTS showed more weight gain (P < 0.0001) and smaller height SDS (P = 0.001) during follow-up. In non-irradiated CBTS, infant-BTS and toddler-BTS were significantly more frequently diagnosed with TSH-, ACTH-, and ADH deficiency, compared to older-BTS. Conclusion Infant and toddler brain tumor survivors seem to be more vulnerable to develop HP dysfunction than older children. These results emphasize the importance of special infant and toddler brain tumor treatment protocols and the need for endocrine surveillance in children treated for a brain tumor at a young age. |
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| ISSN: | 1479683X 08044643 |
| DOI: | 10.1530/eje-21-0137 |