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Physical activity levels are positively related to progression-free survival and reduced adverse events in advanced ER+ breast cancer

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Název: Physical activity levels are positively related to progression-free survival and reduced adverse events in advanced ER+ breast cancer
Autoři: Zimmer, Philipp, Esser, Tobias, Lueftner, Diana, Schuetz, Florian, Baumann, Freerk T., Rody, Achim, Schneeweiss, Andreas, Hartkopf, Andreas D., Decker, Thomas, Uleer, Christoph, Stoetzer, Oliver J., Foerster, Frank, Schmidt, Marcus, Mundhenke, Christoph, Steindorf, Karen, Tesch, Hans, Jackisch, Christian, Fischer, Thomas, Hanson, Sven, Kreuzeder, Julia, Guderian, Gernot, Fasching, Peter A., Bloch, Wilhelm
Zdroj: BMC Med
BMC Medicine, Vol 22, Iss 1, Pp 1-10 (2024)
Informace o vydavateli: Springer Science and Business Media LLC, 2024.
Rok vydání: 2024
Témata: Quality of life, Survival, Breast Neoplasms, Körperliche Aktivität, Erschöpfung, Breast cancer, Germany, Brustkrebs, Humans, Female [MeSH], Aged [MeSH], Postmenopause [MeSH], Receptors, Estrogen/metabolism [MeSH], Humans [MeSH], Prospective Studies [MeSH], Progression-Free Survival [MeSH], Middle Aged [MeSH], Androstadienes/therapeutic use [MeSH], Fatigue [MeSH], Exercise/physiology [MeSH], Adverse events, Exercise, Breast Neoplasms [MeSH], Fatigue, Quality of Life [MeSH], Germany [MeSH], Physical activity, Research Article, Everolimus/therapeutic use [MeSH], Prospective Studies, Everolimus, Aged, Sport, Lebensqualität, Middle Aged, Progression-Free Survival, Letalität, Androstadienes, Postmenopause, Receptors, Estrogen, Quality of Life, Medicine, Female
Popis: Background Increased levels of physical activity are associated with a reduction of breast cancer mortality, especially in postmenopausal women with positive hormone receptor status. So far, previous observational case–control and cohort studies have focused on associations between overall leisure time physical activity and survival of women with breast cancer in general. Methods In this multicenter prospective cohort study, conducted in Germany between 30th August 2012 to 29th December 2017, we investigated general physical activity in a homogenous sample of n = 1440 postmenopausal women with advanced (inoperable locally advanced or metastatic), hormone receptor-positive breast cancer receiving the same therapy (everolimus and exemestane). Self-reported physical activity was assessed using the Godin Leisure Time Exercise Questionnaire (GLTEQ) before and every 3 months during treatment. Participants were then classified into “active” and “insufficiently active” to screen their activity behavior the week prior to medical treatment. In addition, changes in physical activity patterns were assessed. Adjusted Cox regression analyses were performed for the activity categories to determine hazard ratios (HR). Besides progression-free survival (PFS), adverse events (AEs), QoL, and fatigue were assessed every 3 months until study termination. Results Compared to “insufficiently active” patients, “active” individuals indicated a significantly longer PFS (HR: 0.84 [0.74; 0.984], p = .0295). No significant differences were observed for changes of physical activity behavior. Patients who reported to be “active” at baseline revealed significantly fewer AEs compared to “insufficiently” active patients. In detail, both severe and non-severe AEs occurred less frequently in the “active” patients group. In line with that, QoL and fatigue were better in physical “active” patients compared to their insufficient active counterparts at the last post-baseline assessment. Participants who remained or become active indicated less AEs, a higher QoL, and reduced fatigue levels. Conclusions Physical activity behavior prior to medical treatment might have prognostic value in patients with advanced breast cancer in terms of extending the PFS. Moreover, physical activity before and during treatment may reduce treatment-related side effects and improve patients’ QoL and fatigue. Trial registration EUPAS9462. Registered 30th October 2012 “retrospectively registered.”
Druh dokumentu: Article
Other literature type
Jazyk: English
ISSN: 1741-7015
DOI: 10.1186/s12916-024-03671-x
DOI: 10.17877/de290r-25528
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39379960
https://doaj.org/article/8b259c9cfcde41269ea27b87fe454bf7
https://repository.publisso.de/resource/frl:6499841
Rights: CC BY
Přístupové číslo: edsair.doi.dedup.....29bb9b6b96f4de46877e985afbbb424f
Databáze: OpenAIRE
Popis
Abstrakt:Background Increased levels of physical activity are associated with a reduction of breast cancer mortality, especially in postmenopausal women with positive hormone receptor status. So far, previous observational case–control and cohort studies have focused on associations between overall leisure time physical activity and survival of women with breast cancer in general. Methods In this multicenter prospective cohort study, conducted in Germany between 30th August 2012 to 29th December 2017, we investigated general physical activity in a homogenous sample of n = 1440 postmenopausal women with advanced (inoperable locally advanced or metastatic), hormone receptor-positive breast cancer receiving the same therapy (everolimus and exemestane). Self-reported physical activity was assessed using the Godin Leisure Time Exercise Questionnaire (GLTEQ) before and every 3 months during treatment. Participants were then classified into “active” and “insufficiently active” to screen their activity behavior the week prior to medical treatment. In addition, changes in physical activity patterns were assessed. Adjusted Cox regression analyses were performed for the activity categories to determine hazard ratios (HR). Besides progression-free survival (PFS), adverse events (AEs), QoL, and fatigue were assessed every 3 months until study termination. Results Compared to “insufficiently active” patients, “active” individuals indicated a significantly longer PFS (HR: 0.84 [0.74; 0.984], p = .0295). No significant differences were observed for changes of physical activity behavior. Patients who reported to be “active” at baseline revealed significantly fewer AEs compared to “insufficiently” active patients. In detail, both severe and non-severe AEs occurred less frequently in the “active” patients group. In line with that, QoL and fatigue were better in physical “active” patients compared to their insufficient active counterparts at the last post-baseline assessment. Participants who remained or become active indicated less AEs, a higher QoL, and reduced fatigue levels. Conclusions Physical activity behavior prior to medical treatment might have prognostic value in patients with advanced breast cancer in terms of extending the PFS. Moreover, physical activity before and during treatment may reduce treatment-related side effects and improve patients’ QoL and fatigue. Trial registration EUPAS9462. Registered 30th October 2012 “retrospectively registered.”
ISSN:17417015
DOI:10.1186/s12916-024-03671-x