Organoids in the Clinic: A Systematic Review of Outcomes: A Systematic Review of Outcomes
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| Titel: | Organoids in the Clinic: A Systematic Review of Outcomes: A Systematic Review of Outcomes |
|---|---|
| Autoren: | Hofmann, Bjørn, Zinöcker, Severin, Holm, Søren, Lewis, Jonathan, Kavouras, Panagiotis |
| Quelle: | Cells Tissues Organs Hofmann, B, Zinöcker, S, Holm, S, Lewis, J & Kavouras, P 2023, ' Organoids in the Clinic : A Systematic Review of Outcomes ', Cells Tissues Organs, vol. 212, no. 6, pp. 499-511 . https://doi.org/10.1159/000527237 Hofmann, B, Zinöcker, S, Holm, S, Lewis, J & Kavouras, P 2022, 'Organoids in the Clinic : A Systematic Review of Outcomes', Cells Tissues Organs, vol. 212, no. 6, pp. 499-511. https://doi.org/10.1159/000527237, https://doi.org/10.1159/000527237 |
| Verlagsinformationen: | S. Karger AG, 2022. |
| Publikationsjahr: | 2022 |
| Schlagwörter: | Organoids, 0206 medical engineering, Systematic review, Outcomes, 02 engineering and technology, 0210 nano-technology, Tissue Engineering − Regenerative Medicine / Systematic Review Article, Evidence, 3. Good health |
| Beschreibung: | Research on organoids has undergone significant advances during the last decade. However, outcomes from the use of organoids in clinical trials have not yet been documented. Therefore, there is an urgent need to assess the reporting of clinically relevant outcomes from organoid research in the scientific literature. This article presents a systematic review and appraisal of the published literature in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, together with a synopsis of recent relevant reviews. Surprisingly, no randomized controlled trials have reported clinical outcomes with any types of organoids. We found very few ongoing and registered studies that may provide clinically relevant results within this decade. Our screening and interpretation of the literature, including review articles, indicate a focus on technical and preclinical aspects of organoid research. This is the first systematic review of clinical trials involving organoids. Few clinical studies are planned or already underway, and, so far, no high-quality evidence relating to the clinical outcomes of organoid research has been published. The many promises of organoid research still need to be translated from bench to bed. |
| Publikationsart: | Article Other literature type |
| Dateibeschreibung: | application/pdf |
| Sprache: | English |
| ISSN: | 1422-6421 1422-6405 |
| DOI: | 10.1159/000527237 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/36170843 https://research.manchester.ac.uk/en/publications/a834d0af-1778-4643-b99c-29c0013e371c https://doi.org/10.1159/000527237 http://www.scopus.com/inward/record.url?scp=85160112484&partnerID=8YFLogxK https://hdl.handle.net/11250/3046150 https://hdl.handle.net/11250/3046208 |
| Rights: | CC BY NC URL: http://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission. |
| Dokumentencode: | edsair.doi.dedup.....267a2c6b4c42474aaedc0c1c0725e9b3 |
| Datenbank: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstract: | Research on organoids has undergone significant advances during the last decade. However, outcomes from the use of organoids in clinical trials have not yet been documented. Therefore, there is an urgent need to assess the reporting of clinically relevant outcomes from organoid research in the scientific literature. This article presents a systematic review and appraisal of the published literature in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, together with a synopsis of recent relevant reviews. Surprisingly, no randomized controlled trials have reported clinical outcomes with any types of organoids. We found very few ongoing and registered studies that may provide clinically relevant results within this decade. Our screening and interpretation of the literature, including review articles, indicate a focus on technical and preclinical aspects of organoid research. This is the first systematic review of clinical trials involving organoids. Few clinical studies are planned or already underway, and, so far, no high-quality evidence relating to the clinical outcomes of organoid research has been published. The many promises of organoid research still need to be translated from bench to bed. |
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| ISSN: | 14226421 14226405 |
| DOI: | 10.1159/000527237 |