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Plasma metabolomic profiling of dietary patterns associated with glucose metabolism status: The Maastricht Study: The Maastricht Study

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Titel: Plasma metabolomic profiling of dietary patterns associated with glucose metabolism status: The Maastricht Study: The Maastricht Study
Autoren: Evan Yi-Wen Yu, Zhewen Ren, Siamak Mehrkanoon, Coen D. A. Stehouwer, Marleen M. J. van Greevenbroek, Simone J. P. M. Eussen, Maurice P. Zeegers, Anke Wesselius
Weitere Verfasser: Sub Algorithmic Data Analysis, Sub Pharmacotherapy, Theoretical, Algorithmic Data Analysis
Quelle: BMC Med
BMC Medicine, Vol 20, Iss 1, Pp 1-16 (2022)
Verlagsinformationen: Springer Science and Business Media LLC, 2022.
Publikationsjahr: 2022
Schlagwörter: 0301 basic medicine, Mediterranean, Diet, Mediterranean, Prediabetic State, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Diabetes Mellitus, Humans, Metabolomics, Prospective Studies, Dietary patterns, Type 2/epidemiology, Prediabetic State/epidemiology, 2. Zero hunger, Glucose metabolism, General Medicine, Middle Aged, Diet, 3. Good health, Cross-Sectional Studies, Glucose, Diabetes Mellitus, Type 2, Molecular epidemiology, Medicine, Cohort study, Research Article
Beschreibung: Background Glucose metabolism has been reported to be affected by dietary patterns, while the underlying mechanisms involved remain unclear. This study aimed to investigate the potential mediation role of circulating metabolites in relation to dietary patterns for prediabetes and type 2 diabetes. Methods Data was derived from The Maastricht Study that comprised of 3441 participants (mean age of 60 years) with 28% type 2 diabetes patients by design. Dietary patterns were assessed using a validated food frequency questionnaire (FFQ), and the glucose metabolism status (GMS) was defined according to WHO guidelines. Both cross-sectional and prospective analyses were performed for the circulating metabolome to investigate their associations and mediations with responses to dietary patterns and GMS. Results Among 226 eligible metabolite measures obtained from targeted metabolomics, 14 were identified to be associated and mediated with three dietary patterns (i.e. Mediterranean Diet (MED), Dietary Approaches to Stop Hypertension Diet (DASH), and Dutch Healthy Diet (DHD)) and overall GMS. Of these, the mediation effects of 5 metabolite measures were consistent for all three dietary patterns and GMS. Based on a 7-year follow-up, a decreased risk for apolipoprotein A1 (APOA1) and docosahexaenoic acid (DHA) (RR 0.60, 95% CI 0.55, 0.65; RR 0.89, 95% CI 0.83, 0.97, respectively) but an increased risk for ratio of ω-6 to ω-3 fatty acids (RR 1.29, 95% CI 1.05, 1.43) of type 2 diabetes were observed from prediabetes, while APOA1 showed a decreased risk of type 2 diabetes from normal glucose metabolism (NGM; RR 0.82, 95% CI 0.75, 0.89). Conclusions In summary, this study suggests that adherence to a healthy dietary pattern (i.e. MED, DASH, or DHD) could affect the GMS through circulating metabolites, which provides novel insights into understanding the biological mechanisms of diet on glucose metabolism and leads to facilitating prevention strategy for type 2 diabetes.
Publikationsart: Article
Other literature type
Dateibeschreibung: application/pdf
Sprache: English
ISSN: 1741-7015
DOI: 10.1186/s12916-022-02653-1
Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/36414942
https://doaj.org/article/205cd320a1734b06b48aa9a09010e10b
https://cris.maastrichtuniversity.nl/en/publications/fb8b4673-aa7e-40d6-9743-a2bdac4ea581
https://doi.org/10.1186/s12916-022-02653-1
https://research-portal.uu.nl/en/publications/92bb69c2-9e51-4321-b78d-8ee0fe8c7779
https://doi.org/10.1186/s12916-022-02653-1
https://dspace.library.uu.nl/handle/1874/431863
Rights: CC BY
Dokumentencode: edsair.doi.dedup.....24e7001a6dbec5d012eb0a5fe2d88566
Datenbank: OpenAIRE
Beschreibung
Abstract:Background Glucose metabolism has been reported to be affected by dietary patterns, while the underlying mechanisms involved remain unclear. This study aimed to investigate the potential mediation role of circulating metabolites in relation to dietary patterns for prediabetes and type 2 diabetes. Methods Data was derived from The Maastricht Study that comprised of 3441 participants (mean age of 60 years) with 28% type 2 diabetes patients by design. Dietary patterns were assessed using a validated food frequency questionnaire (FFQ), and the glucose metabolism status (GMS) was defined according to WHO guidelines. Both cross-sectional and prospective analyses were performed for the circulating metabolome to investigate their associations and mediations with responses to dietary patterns and GMS. Results Among 226 eligible metabolite measures obtained from targeted metabolomics, 14 were identified to be associated and mediated with three dietary patterns (i.e. Mediterranean Diet (MED), Dietary Approaches to Stop Hypertension Diet (DASH), and Dutch Healthy Diet (DHD)) and overall GMS. Of these, the mediation effects of 5 metabolite measures were consistent for all three dietary patterns and GMS. Based on a 7-year follow-up, a decreased risk for apolipoprotein A1 (APOA1) and docosahexaenoic acid (DHA) (RR 0.60, 95% CI 0.55, 0.65; RR 0.89, 95% CI 0.83, 0.97, respectively) but an increased risk for ratio of ω-6 to ω-3 fatty acids (RR 1.29, 95% CI 1.05, 1.43) of type 2 diabetes were observed from prediabetes, while APOA1 showed a decreased risk of type 2 diabetes from normal glucose metabolism (NGM; RR 0.82, 95% CI 0.75, 0.89). Conclusions In summary, this study suggests that adherence to a healthy dietary pattern (i.e. MED, DASH, or DHD) could affect the GMS through circulating metabolites, which provides novel insights into understanding the biological mechanisms of diet on glucose metabolism and leads to facilitating prevention strategy for type 2 diabetes.
ISSN:17417015
DOI:10.1186/s12916-022-02653-1