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Lipid compounds of the umbilical cord artery and their alterations in preeclampsia

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Název: Lipid compounds of the umbilical cord artery and their alterations in preeclampsia
Autoři: Lech Romanowicz, Edward Bańkowski
Zdroj: Atherosclerosis. 204:e44-e51
Informace o vydavateli: Elsevier BV, 2009.
Rok vydání: 2009
Témata: thin layer, Adult, 0301 basic medicine, Lipids - analysis, Umbilical arteries - chemistry, Gestational Age, Case-control studies, Fatty Acids, Nonesterified, Umbilical Arteries, Diglycerides, Young Adult, 03 medical and health sciences, Pre-Eclampsia, Pregnancy, nonesterified - analysis, high pressure liquid, Humans, Cholesterol esters - analysis, Diglycerides - analysis, Fatty acids, Chromatography, High Pressure Liquid, Triglycerides, Chromatography, 0303 health sciences, Monoglycerides - analysis, Cholesterol - analysis, Gestational age, unsaturated - analysis, Lipids, 3. Good health, Young adult, Cholesterol, Case-Control Studies, Fatty Acids, Unsaturated, Monoglycerides, Triglycerides - analysis, Female, Cholesterol Esters, Chromatography, Thin Layer, Pre-eclampsia - metabolism
Popis: The lipid composition of arterial walls changes during development, ageing and pathological processes. Preeclampsia is the most common pregnancy-associated pathological syndrome. It is accompanied by significant remodelling of the extracellular matrix, both in the umbilical cord vessels and in the surrounding Wharton's jelly. Lipids of the umbilical cord have not been extensively studied. Here we evaluate the lipid composition of the umbilical cord artery (UCA) and its alteration in preeclampsia. Thin layer chromatography and high-performance liquid chromatography were employed for these analyses. It was found that the UCA wall, as with most human tissues, contains free fatty acids, mono-, di- and triacylglycerols, free cholesterol and its esters. The characteristic feature of the UCA wall is the presence of high amounts of long chain polyunsaturated fatty acids (PUFA), including eicosapentaenoic acid (C20:5) and docosahexaenoic acid (C22:6), which are rather minor lipid components of most human tissues. They exist both in a free form and in a form of acylglycerols and cholesterol esters. Preeclampsia is associated with a marked decrease in most free fatty acids and acylglycerols. The total amount of long chain PUFA: C18:2, C:18:3, C20:4, C20:5 and C22:6 in these lipid fractions is decreased by half, with a concomitant increase in free cholesterol and its esters. We propose that these lower levels of PUFA may reduce prostaglandin synthesis in the arterial wall and thereby impair blood flow in the foetal vascular system, leading to preeclamptic symptoms.
Druh dokumentu: Article
Jazyk: English
ISSN: 0021-9150
DOI: 10.1016/j.atherosclerosis.2008.11.008
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/19110248
https://pubmed.ncbi.nlm.nih.gov/19110248/
https://www.sciencedirect.com/science/article/pii/S0021915008007892
Rights: Elsevier TDM
Přístupové číslo: edsair.doi.dedup.....2491b7e3486b024c0bb66d4ed85c8270
Databáze: OpenAIRE
Popis
Abstrakt:The lipid composition of arterial walls changes during development, ageing and pathological processes. Preeclampsia is the most common pregnancy-associated pathological syndrome. It is accompanied by significant remodelling of the extracellular matrix, both in the umbilical cord vessels and in the surrounding Wharton's jelly. Lipids of the umbilical cord have not been extensively studied. Here we evaluate the lipid composition of the umbilical cord artery (UCA) and its alteration in preeclampsia. Thin layer chromatography and high-performance liquid chromatography were employed for these analyses. It was found that the UCA wall, as with most human tissues, contains free fatty acids, mono-, di- and triacylglycerols, free cholesterol and its esters. The characteristic feature of the UCA wall is the presence of high amounts of long chain polyunsaturated fatty acids (PUFA), including eicosapentaenoic acid (C20:5) and docosahexaenoic acid (C22:6), which are rather minor lipid components of most human tissues. They exist both in a free form and in a form of acylglycerols and cholesterol esters. Preeclampsia is associated with a marked decrease in most free fatty acids and acylglycerols. The total amount of long chain PUFA: C18:2, C:18:3, C20:4, C20:5 and C22:6 in these lipid fractions is decreased by half, with a concomitant increase in free cholesterol and its esters. We propose that these lower levels of PUFA may reduce prostaglandin synthesis in the arterial wall and thereby impair blood flow in the foetal vascular system, leading to preeclamptic symptoms.
ISSN:00219150
DOI:10.1016/j.atherosclerosis.2008.11.008