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Ameliorative Effects of Alkaloids from Narcissus cv. Hawera: Behavioral Changes Following Acute and Accelerated Chronic Restraint Stress

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Název: Ameliorative Effects of Alkaloids from Narcissus cv. Hawera: Behavioral Changes Following Acute and Accelerated Chronic Restraint Stress
Autoři: Daniela Pechlivanova, Petar Grozdanov, Zafer Sabit, Dimitar Bakalov, Alexander Stoynev, Strahil Berkov
Zdroj: Revista Brasileira de Farmacognosia. 33:1309-1314
Informace o vydavateli: Springer Science and Business Media LLC, 2023.
Rok vydání: 2023
Témata: Antinociception, Alkaloids dereplication, Sceletium-type alkaloids, Anxiety, Corticosterone, Anxiolytics
Popis: The adverse effects of stress explain the increased demand for phytochemical and biochemical pharmacological agents with potential adaptogenic effects. Narcissus cv. Hawera (a N. jonquilla x N. triandrus hybrid), Amaryllidaceae, has been recently found to biosynthesize a number of Sceletium-type alkaloids that show anxiolytic and antidepressant activities. The aim of the present study was to elucidate the effects of the Narcissus cv. Hawera alkaloidal fraction rich in Sceletium-type alkaloids on behavioral abnormalities following exposure to acute and chronic restraint stress in rats. The alkaloidal fraction, consisting of 6-epi-mesembranol, 6-epi-mesembrenol, sanguinine, and mesembrenone as main components, was applied before the stress to Wistar male rats. Behavioral parameters were assessed using forced swimming, open field, elevated plus-maze, and paw pressure tests. Blood corticosterone was measured by ELISA. The main effects of the alkaloidal fraction were the normalization of corticosterone levels, anxiolysis, and antinociception, which were not accompanied by a reduction in normal exploratory behavior. These findings point to the potential of the studied alkaloidal fraction as a new source of stress relievers.
Druh dokumentu: Article
Popis souboru: application/pdf
Jazyk: English
ISSN: 1981-528X
DOI: 10.1007/s43450-023-00464-w
Rights: Springer Nature TDM
Přístupové číslo: edsair.doi.dedup.....243cdf70d77796c5f27593fc02ef6403
Databáze: OpenAIRE
Popis
Abstrakt:The adverse effects of stress explain the increased demand for phytochemical and biochemical pharmacological agents with potential adaptogenic effects. Narcissus cv. Hawera (a N. jonquilla x N. triandrus hybrid), Amaryllidaceae, has been recently found to biosynthesize a number of Sceletium-type alkaloids that show anxiolytic and antidepressant activities. The aim of the present study was to elucidate the effects of the Narcissus cv. Hawera alkaloidal fraction rich in Sceletium-type alkaloids on behavioral abnormalities following exposure to acute and chronic restraint stress in rats. The alkaloidal fraction, consisting of 6-epi-mesembranol, 6-epi-mesembrenol, sanguinine, and mesembrenone as main components, was applied before the stress to Wistar male rats. Behavioral parameters were assessed using forced swimming, open field, elevated plus-maze, and paw pressure tests. Blood corticosterone was measured by ELISA. The main effects of the alkaloidal fraction were the normalization of corticosterone levels, anxiolysis, and antinociception, which were not accompanied by a reduction in normal exploratory behavior. These findings point to the potential of the studied alkaloidal fraction as a new source of stress relievers.
ISSN:1981528X
DOI:10.1007/s43450-023-00464-w