Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein can reflect systemic lupus erythematosus activity
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| Title: | Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein can reflect systemic lupus erythematosus activity |
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| Authors: | Sang Won Lee, Younhee Park, Alfred L. M. Bothwell, Seung Min Jung, Jason Jungsik Song, Yoon-Ah Park, Sung Soo Ahn, D. D. Lee |
| Contributors: | College of Medicine, Dept. of Internal Medicine, S S Ahn, Y Park, D D Lee, A L M Bothwell, S M Jung, J J Song, Y-B Park, S-W Lee, Park, Yong Beom, Song, Jung Sik, Ahn, Sung Soo, Lee, Sang Won, Jung, Seung Min |
| Source: | Lupus. 27:771-779 |
| Publisher Information: | SAGE Publications, 2017. |
| Publication Year: | 2017 |
| Subject Terms: | Adult, Male, Mac-2 binding protein, Blood Sedimentation, 7. Clean energy, 03 medical and health sciences, Systemic lupus erythematosus, 0302 clinical medicine, Antigens, Neoplasm, galectin-3, Biomarkers, Tumor, Humans, Lupus Erythematosus, Systemic, Glycoproteins, Immunoassay, Chi-Square Distribution, Membrane Glycoproteins, Middle Aged, 3. Good health, C-Reactive Protein, Logistic Models, 13. Climate action, Multivariate Analysis, Linear Models, Wisteria floribunda, Female, Inflammation Mediators, Carrier Proteins, disease activity, Biomarkers |
| Description: | Serum Mac-2-binding protein (M2BP) is elevated in various chronic inflammatory diseases, and evidence suggests that glycosylation of M2BP induces discrete biological effects. However, the role of serum M2BP in systemic lupus erythematosus (SLE) is still unclear. Recently, a Wisteria floribunda agglutinin-positive–M2BP (WFA+–M2BP) immunoassay has shown promise in detecting highly glycosylated M2BP. In this study, by using WFA+–M2BP immunoassay, we measured serum M2BP in 203 SLE patients and evaluated its clinical significance. Eighty patients were classified as having active SLE and 123 patients as having inactive SLE. The median serum M2BP was higher in patients with active SLE than in those with inactive SLE (2.1 vs. 0.9, p |
| Document Type: | Article |
| Language: | English |
| ISSN: | 1477-0962 0961-2033 |
| DOI: | 10.1177/0961203317747719 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/29233037 https://ir.ymlib.yonsei.ac.kr/handle/22282913/162178 https://journals.sagepub.com/doi/abs/10.1177/0961203317747719 https://yonsei.pure.elsevier.com/en/publications/serum-wisteria-floribunda-agglutinin-positive-mac-2-binding-prote http://journals.sagepub.com/doi/abs/10.1177/0961203317747719 https://pubmed.ncbi.nlm.nih.gov/29233037/ https://www.ncbi.nlm.nih.gov/pubmed/29233037 |
| Rights: | CC BY NC ND URL: https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| Accession Number: | edsair.doi.dedup.....243cc71ed8d6eca592b29668745e302b |
| Database: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstract: | Serum Mac-2-binding protein (M2BP) is elevated in various chronic inflammatory diseases, and evidence suggests that glycosylation of M2BP induces discrete biological effects. However, the role of serum M2BP in systemic lupus erythematosus (SLE) is still unclear. Recently, a Wisteria floribunda agglutinin-positive–M2BP (WFA+–M2BP) immunoassay has shown promise in detecting highly glycosylated M2BP. In this study, by using WFA+–M2BP immunoassay, we measured serum M2BP in 203 SLE patients and evaluated its clinical significance. Eighty patients were classified as having active SLE and 123 patients as having inactive SLE. The median serum M2BP was higher in patients with active SLE than in those with inactive SLE (2.1 vs. 0.9, p |
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| ISSN: | 14770962 09612033 |
| DOI: | 10.1177/0961203317747719 |