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Differentiated somatic gene expression is triggered in the dorsal hippocampus and the anterior retrosplenial cortex by hippocampal synaptic plasticity prompted by spatial content learning

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Název: Differentiated somatic gene expression is triggered in the dorsal hippocampus and the anterior retrosplenial cortex by hippocampal synaptic plasticity prompted by spatial content learning
Autoři: Thu-Huong Hoang, Denise Manahan-Vaughan
Zdroj: Brain Struct Funct
Informace o vydavateli: Springer Science and Business Media LLC, 2023.
Rok vydání: 2023
Témata: Neuronal Plasticity, Long-Term Synaptic Depression, Long-Term Potentiation, Spatial Learning, Gene Expression, Gyrus Cinguli, Hippocampus, Rats, Synapses, Animals, Original Article, CA1 Region, Hippocampal/metabolism [MeSH], Information encoding, Spatial learning, Synaptic plasticity, Rats [MeSH], Gene Expression [MeSH], Animals [MeSH], Immediate early gene, Long-Term Potentiation/physiology [MeSH], Long-Term Synaptic Depression/physiology [MeSH], Synapses [MeSH], Gyrus Cinguli [MeSH], Neuronal Plasticity [MeSH], Retrosplenial cortex, Spatial Learning/physiology [MeSH], Hippocampus/metabolism [MeSH], In Situ Hybridization, Fluorescence [MeSH], CA1 Region, Hippocampal, In Situ Hybridization, Fluorescence
Popis: Hippocampal afferent inputs, terminating on proximal and distal subfields of the cornus ammonis (CA), enable the functional discrimination of ‘what’ (item identity) and ‘where’ (spatial location) elements of a spatial representation. This kind of information is supported by structures such as the retrosplenial cortex (RSC). Spatial content learning promotes the expression of hippocampal synaptic plasticity, particularly long-term depression (LTD). In the CA1 region, this is specifically facilitated by the learning of item-place features of a spatial environment. Gene-tagging, by means of time-locked fluorescence in situ hybridization (FISH) to detect nuclear expression of immediate early genes, can reveal neuronal populations that engage in experience-dependent information encoding. In the current study, using FISH, we examined if learning-facilitated LTD results in subfield-specific information encoding in the hippocampus and RSC. Rats engaged in novel exploration of small items during stimulation of Schaffer collateral-CA1 synapses. This resulted in LTD (> 24 h). FISH, to detect nuclear expression of Homer1a, revealed that the distal-CA1 and proximal-CA3 subcompartments were particularly activated by this event. By contrast, all elements of the proximodistal cornus ammonis-axis showed equal nuclear Homer1a expression following LTD induction solely by means of afferent stimulation. The RSC exhibited stronger nuclear Homer1a expression in response to learning-facilitated LTD, and to novel item-place experience, compared to LTD induced by sole afferent stimulation in CA1. These results show that both the cornus ammonis and RSC engage in differentiated information encoding of item-place learning that is salient enough, in its own right, to drive the expression of hippocampal LTD. These results also reveal a novel role of the RSC in item-place learning.
Druh dokumentu: Article
Other literature type
Jazyk: English
ISSN: 1863-2661
DOI: 10.1007/s00429-023-02694-z
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/37690045
https://repository.publisso.de/resource/frl:6493642
Rights: CC BY
Přístupové číslo: edsair.doi.dedup.....23558c6d59984dcb2548d74caa8d1262
Databáze: OpenAIRE
Popis
Abstrakt:Hippocampal afferent inputs, terminating on proximal and distal subfields of the cornus ammonis (CA), enable the functional discrimination of ‘what’ (item identity) and ‘where’ (spatial location) elements of a spatial representation. This kind of information is supported by structures such as the retrosplenial cortex (RSC). Spatial content learning promotes the expression of hippocampal synaptic plasticity, particularly long-term depression (LTD). In the CA1 region, this is specifically facilitated by the learning of item-place features of a spatial environment. Gene-tagging, by means of time-locked fluorescence in situ hybridization (FISH) to detect nuclear expression of immediate early genes, can reveal neuronal populations that engage in experience-dependent information encoding. In the current study, using FISH, we examined if learning-facilitated LTD results in subfield-specific information encoding in the hippocampus and RSC. Rats engaged in novel exploration of small items during stimulation of Schaffer collateral-CA1 synapses. This resulted in LTD (> 24 h). FISH, to detect nuclear expression of Homer1a, revealed that the distal-CA1 and proximal-CA3 subcompartments were particularly activated by this event. By contrast, all elements of the proximodistal cornus ammonis-axis showed equal nuclear Homer1a expression following LTD induction solely by means of afferent stimulation. The RSC exhibited stronger nuclear Homer1a expression in response to learning-facilitated LTD, and to novel item-place experience, compared to LTD induced by sole afferent stimulation in CA1. These results show that both the cornus ammonis and RSC engage in differentiated information encoding of item-place learning that is salient enough, in its own right, to drive the expression of hippocampal LTD. These results also reveal a novel role of the RSC in item-place learning.
ISSN:18632661
DOI:10.1007/s00429-023-02694-z