Zobrazit v EDS

Stroke Recovery–Related Changes in Cortical Reactivity Based on Modulation of Intracortical Inhibition

Uloženo v:
Podrobná bibliografie
Název: Stroke Recovery–Related Changes in Cortical Reactivity Based on Modulation of Intracortical Inhibition
Autoři: Harquel, Sylvain, Cadic-Melchior, Andéol, Morishita, Takuya, Fleury, Lisa, Witon, Adrien, Ceroni, Martino, Bruegger, Julia, Meyer, Nathalie H, Evangelista, Giorgia G, Egger, Philip, Beanato, Elena, Menoud, Pauline, Van De Ville, Dimitri, Micera, Silvestro, Blanke, Olaf, Léger, Bertrand, Adolphsen, Jan, Jagella, Caroline, Constantin, Christophe, Alvarez, Vincent, Vuadens, Philippes, Turlan, Jean-Luc, Mühl, Andreas, Bonvin, Christophe, Koch, Philipp J, Wessel, Maximilian J, Hummel, Friedhelm
Přispěvatelé: Ecole Polytechnique Fédérale de Lausanne (EPFL), Laboratoire de Psychologie et NeuroCognition (LPNC), Université Savoie Mont Blanc (USMB Université de Savoie Université de Chambéry )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)
Zdroj: Stroke. 55:1629-1640
Informace o vydavateli: Ovid Technologies (Wolters Kluwer Health), 2024.
Rok vydání: 2024
Témata: Male, 0301 basic medicine, 616.8, Upper extremity, Evoked potential, Stroke / physiopathology, 03 medical and health sciences, 0302 clinical medicine, Motor Cortex / physiopathology, transcranial magnetic stimulation, Humans, Aged, Aged, 80 and over, 616.0757, [SCCO.NEUR]Cognitive science/Neuroscience, Motor Cortex, Cortical excitability, Neural Inhibition, Electroencephalography, Recovery of Function, Middle Aged, Evoked Potentials, Motor, stroke, Transcranial Magnetic Stimulation, Neural Inhibition / physiology, Stroke, Transcranial Magnetic Stimulation / methods, Electroencephalography EEG, Evoked Potentials, Motor / physiology, Motor cortex, Female, neurophysiology, Transcranial magnetic stimulation, Recovery of Function / physiology
Popis: BACKGROUND: Cortical excitation/inhibition dynamics have been suggested as a key mechanism occurring after stroke. Their supportive or maladaptive role in the course of recovery is still not completely understood. Here, we used transcranial magnetic stimulation (TMS)-electroencephalography coupling to study cortical reactivity and intracortical GABAergic inhibition, as well as their relationship to residual motor function and recovery longitudinally in patients with stroke. METHODS: Electroencephalography responses evoked by TMS applied to the ipsilesional motor cortex were acquired in patients with stroke with upper limb motor deficit in the acute (1 week), early (3 weeks), and late subacute (3 months) stages. Readouts of cortical reactivity, intracortical inhibition, and complexity of the evoked dynamics were drawn from TMS-evoked potentials induced by single-pulse and paired-pulse TMS (short-interval intracortical inhibition). Residual motor function was quantified through a detailed motor evaluation. RESULTS: From 76 patients enrolled, 66 were included (68.2±13.2 years old, 18 females), with a Fugl-Meyer score of the upper extremity of 46.8±19. The comparison with TMS-evoked potentials of healthy older revealed that most affected patients exhibited larger and simpler brain reactivity patterns ( P cluster CONCLUSIONS: The present results revealed an abnormal motor cortical reactivity in patients with stroke, which was driven by perturbations and longitudinal changes within the intracortical inhibition system. They support the view that disinhibition in the ipsilesional motor cortex during the first-week poststroke is beneficial and promotes neuronal plasticity and recovery.
Druh dokumentu: Article
Popis souboru: application/pdf
Jazyk: English
ISSN: 1524-4628
0039-2499
DOI: 10.1161/strokeaha.123.045174
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38639087
Přístupové číslo: edsair.doi.dedup.....23486669fd4c86530268ef0fdcc5a96c
Databáze: OpenAIRE
Popis
Abstrakt:BACKGROUND: Cortical excitation/inhibition dynamics have been suggested as a key mechanism occurring after stroke. Their supportive or maladaptive role in the course of recovery is still not completely understood. Here, we used transcranial magnetic stimulation (TMS)-electroencephalography coupling to study cortical reactivity and intracortical GABAergic inhibition, as well as their relationship to residual motor function and recovery longitudinally in patients with stroke. METHODS: Electroencephalography responses evoked by TMS applied to the ipsilesional motor cortex were acquired in patients with stroke with upper limb motor deficit in the acute (1 week), early (3 weeks), and late subacute (3 months) stages. Readouts of cortical reactivity, intracortical inhibition, and complexity of the evoked dynamics were drawn from TMS-evoked potentials induced by single-pulse and paired-pulse TMS (short-interval intracortical inhibition). Residual motor function was quantified through a detailed motor evaluation. RESULTS: From 76 patients enrolled, 66 were included (68.2±13.2 years old, 18 females), with a Fugl-Meyer score of the upper extremity of 46.8±19. The comparison with TMS-evoked potentials of healthy older revealed that most affected patients exhibited larger and simpler brain reactivity patterns ( P cluster CONCLUSIONS: The present results revealed an abnormal motor cortical reactivity in patients with stroke, which was driven by perturbations and longitudinal changes within the intracortical inhibition system. They support the view that disinhibition in the ipsilesional motor cortex during the first-week poststroke is beneficial and promotes neuronal plasticity and recovery.
ISSN:15244628
00392499
DOI:10.1161/strokeaha.123.045174