Effect of eccentric fixation on the steady-state pattern electroretinogram
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| Názov: | Effect of eccentric fixation on the steady-state pattern electroretinogram |
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| Autori: | Evelyn B. N. Friedel, Julia Haldina, Kathrin Nickel, Michael Bach, Ludger Tebartz van Elst, Sven P. Heinrich |
| Zdroj: | Doc Ophthalmol |
| Informácie o vydavateľovi: | Springer Science and Business Media LLC, 2024. |
| Rok vydania: | 2024 |
| Predmety: | Retinal Ganglion Cells, 03 medical and health sciences, 0302 clinical medicine, Pattern Recognition, Visual, Electroretinography, Humans, Original Research Article, Retinal Ganglion Cells/physiology [MeSH], Pattern Recognition, Visual/physiology [MeSH], Eccentricity, Humans [MeSH], Electroretinography [MeSH], Misfixation, Fixation, PERG, Steady-state PERG, Pattern electroretinogram |
| Popis: | Purpose The steady-state pattern electroretinogram (ssPERG) is used to assess retinal ganglion cell function in a variety of research contexts and diagnostic applications. In certain groups of patients or study participants, stable central fixation of the stimulus is not guaranteed. The present study aimed at assessing the effects of misfixation on the ssPERG response to checkerboard reversal stimuli. Methods Using two check sizes (0.8° and 15°), we compared ssPERG responses for several amounts of fixation deviation, ranging from 0° to 19° horizontally and from 0° to 14° diagonally. The stimulus area extended to 15° eccentricity, stimulus reversal rate was 15/s. Results Up to around 7° eccentricity, there was no sizable effect of fixation deviation under most conditions. Effects were somewhat larger for nasal than for temporal deviation, in particular for small checks. Diagonal deviation was associated with a response to luminance onset/offset at 7.5 Hz (subharmonic of the reversal rate), most prominently when the interior of a large check was fixated. Conclusion Generally, moderate inaccuracies of fixation do not have a sizable effect on ssPERG amplitude. However, with large checks, the luminance response has to be considered. |
| Druh dokumentu: | Article Other literature type |
| Popis súboru: | |
| Jazyk: | English |
| ISSN: | 1573-2622 0012-4486 |
| DOI: | 10.1007/s10633-024-09967-w |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/38416305 https://repository.publisso.de/resource/frl:6494510 |
| Rights: | CC BY |
| Prístupové číslo: | edsair.doi.dedup.....227ca98dcb48d63dbb8ee5b16fc777ca |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Purpose The steady-state pattern electroretinogram (ssPERG) is used to assess retinal ganglion cell function in a variety of research contexts and diagnostic applications. In certain groups of patients or study participants, stable central fixation of the stimulus is not guaranteed. The present study aimed at assessing the effects of misfixation on the ssPERG response to checkerboard reversal stimuli. Methods Using two check sizes (0.8° and 15°), we compared ssPERG responses for several amounts of fixation deviation, ranging from 0° to 19° horizontally and from 0° to 14° diagonally. The stimulus area extended to 15° eccentricity, stimulus reversal rate was 15/s. Results Up to around 7° eccentricity, there was no sizable effect of fixation deviation under most conditions. Effects were somewhat larger for nasal than for temporal deviation, in particular for small checks. Diagonal deviation was associated with a response to luminance onset/offset at 7.5 Hz (subharmonic of the reversal rate), most prominently when the interior of a large check was fixated. Conclusion Generally, moderate inaccuracies of fixation do not have a sizable effect on ssPERG amplitude. However, with large checks, the luminance response has to be considered. |
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| ISSN: | 15732622 00124486 |
| DOI: | 10.1007/s10633-024-09967-w |