Phytochemical, antileishmanial, antifungal and cytotoxic profiles of Thymelaea tartonraira (L.) All. extracts
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| Názov: | Phytochemical, antileishmanial, antifungal and cytotoxic profiles of Thymelaea tartonraira (L.) All. extracts |
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| Autori: | Soltani, Siwar, Koubaa, Imed, Cojean, Sandrine, Picot, Carine, Marchand, Pascal, Allouche, Noureddine |
| Prispievatelia: | NantesU M, Dépôt, Université de Sfax - University of Sfax, Biomolécules : Conception, Isolement, Synthèse (BioCIS), Institut de Chimie - CNRS Chimie (INC-CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), Cibles et Médicaments des Infections et de l'Immunité - UR 1155 (IICiMed), Nantes Université - UFR des Sciences Pharmaceutiques et Biologiques (Nantes Univ - UFR Pharmacie), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ) |
| Zdroj: | Natural Product Research. 38:3481-3487 |
| Informácie o vydavateľovi: | Informa UK Limited, 2023. |
| Rok vydania: | 2023 |
| Predmety: | 0301 basic medicine, Antifungal Agents, Phytochemicals, MESH: Plant Extracts, Antiprotozoal Agents, LC-ESI-MS analysis, thymelaea tartonraira (L.) all, Microbial Sensitivity Tests, 01 natural sciences, Mice, 03 medical and health sciences, Candida albicans, MESH: RAW 264.7 Cells, Animals, MESH: Phytochemicals, MESH: Animals, MESH: Antiprotozoal Agents, MESH: Mice, Flavonoids, MESH: Plant Stems, MESH: Microbial Sensitivity Tests, MESH: Leishmania donovani, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Plant Stems, Plant Extracts, MESH: Candida albicans, Aspergillus fumigatus, Macrophages, antifungal activity, MESH: Macrophages, Antileishmanial activity, MESH: Antifungal Agents, 3. Good health, 0104 chemical sciences, MESH: Plant Leaves, Plant Leaves, RAW 264.7 Cells, cytotoxicity, MESH: Aspergillus fumigatus, MESH: Flavonoids, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Leishmania donovani |
| Popis: | Extracts from leaves and stems of Thymelaea tartonraira (L.) All. growing in Tunisia were characterised for the presence of flavonoids and phenolic acids by LC-ESI-MS analysis. Twelve flavonoids and ten phenolic acids were detected for the first time in the aerial parts of this plant species, the most abundant compounds being gallic acid, kaempferol, catechin, chlorogenic acid, naringenin and acacetin. The extracts were subjected to in vitro antileishmanial, antifungal and cytotoxic assays, showing promising antileishmanial activity for the E6 dichloromethane extract from the stems (IC50 values of 1.12 ± 0.50 and 5.41 ± 1.84 µg/mL on L. donovani axenic and intramacrophagic amastigotes, respectively) at the level of the reference drug miltefosine for axenic model. No antifungal activity was observed against Candida albicans (CAAL) and Aspergillus fumigatus (ASFU) strains, with the exception of the E6 dichloromethane extract (IC50 value of 25.28 ± 4.89 µg/mL on CAAL93 strain). Low toxicity was also highlighted against macrophages Raw 264.7 cells. These promising results point out Thymelaea tartonraira (L.) All. extracts as a valuable source of new natural products to combat leishmaniasis. |
| Druh dokumentu: | Article Other literature type |
| Jazyk: | English |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2023.2252153 |
| DOI: | 10.6084/m9.figshare.24058896.v1 |
| DOI: | 10.6084/m9.figshare.24058896 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/37647092 https://nantes-universite.hal.science/hal-04805245v1 https://doi.org/10.1080/14786419.2023.2252153 |
| Rights: | CC BY |
| Prístupové číslo: | edsair.doi.dedup.....2193d1b638b8010bfaf32d1762ee2976 |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Extracts from leaves and stems of Thymelaea tartonraira (L.) All. growing in Tunisia were characterised for the presence of flavonoids and phenolic acids by LC-ESI-MS analysis. Twelve flavonoids and ten phenolic acids were detected for the first time in the aerial parts of this plant species, the most abundant compounds being gallic acid, kaempferol, catechin, chlorogenic acid, naringenin and acacetin. The extracts were subjected to in vitro antileishmanial, antifungal and cytotoxic assays, showing promising antileishmanial activity for the E6 dichloromethane extract from the stems (IC50 values of 1.12 ± 0.50 and 5.41 ± 1.84 µg/mL on L. donovani axenic and intramacrophagic amastigotes, respectively) at the level of the reference drug miltefosine for axenic model. No antifungal activity was observed against Candida albicans (CAAL) and Aspergillus fumigatus (ASFU) strains, with the exception of the E6 dichloromethane extract (IC50 value of 25.28 ± 4.89 µg/mL on CAAL93 strain). Low toxicity was also highlighted against macrophages Raw 264.7 cells. These promising results point out Thymelaea tartonraira (L.) All. extracts as a valuable source of new natural products to combat leishmaniasis. |
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| ISSN: | 14786427 14786419 |
| DOI: | 10.1080/14786419.2023.2252153 |