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Association of Mixed Use of Electronic and Conventional Cigarettes and Exposure to Secondhand Smoke With Prediabetes

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Title: Association of Mixed Use of Electronic and Conventional Cigarettes and Exposure to Secondhand Smoke With Prediabetes
Authors: Seung Hoon Kim, Minah Park, Gyu Ri Kim, Hye Jin Joo, Sung-In Jang
Contributors: Seung Hoon Kim, Minah Park, Gyu Ri Kim, Hye Jin Joo, Sung-In Jang, Kim, Gyu Ri
Source: The Journal of Clinical Endocrinology & Metabolism. 107:e44-e56
Publisher Information: The Endocrine Society, 2021.
Publication Year: 2021
Subject Terms: Adult, Male, HbA1c, prediabetes, Electronic Nicotine Delivery Systems, Prediabetic State, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Smoking / adverse effects, Surveys and Questionnaires, Republic of Korea, Diabetes Mellitus, Humans, Diabetes Mellitus / pathology, Environmental Exposure / adverse effects, Republic of Korea / epidemiology, Aged, conventional cigarette, Prediabetic State / etiology, Tobacco Smoke Pollution / adverse effects, Smoking, Diabetes Mellitus / epidemiology, Electronic Nicotine Delivery Systems / statistics & numerical data, Prediabetic State / pathology, Environmental Exposure, Middle Aged, Prognosis, 16. Peace & justice, Diabetes Mellitus / etiology, Prediabetic State / epidemiology, 3. Good health, electronic cigarette, Cross-Sectional Studies, Female, Tobacco Smoke Pollution, secondhand smoke, Follow-Up Studies
Description: Context Despite previous studies regarding the association between smoking and diabetes, the effects of electronic cigarettes and secondhand smoke (SHS) on glucose metabolism and insulin sensitivity have not been fully elucidated. Objective To examine the association of mixed electronic and conventional cigarette use and exposure to SHS with prediabetes. Design Data from the 2014-2018 Korean National Health and Nutrition Examination Survey were analyzed. Setting Nationwide population-based. Participants Of 39 199 participants, 22 385 participants (9490 men, 12 895 women) without diabetes were included. The main independent variables were smoking behaviors, including exposure to SHS. Interventions None. Main Outcome Measures Prediabetes (hemoglobin A1C of 5.7-6.4%). Results Of 22 385 participants without diabetes, 6735 had prediabetes. Mixed cigarette use was associated with a 1.57-fold increase in the odds of prediabetes when compared with never-smoking [odds ratio (OR) = 1.57, 95% CI = 1.29-1.92] and a 1.27-fold increase when compared with conventional cigarette use only (OR = 1.27, 95% CI = 1.07-1.52). Participants who were current nonsmokers, but mixed users in the past had an increased risk of prediabetes (OR = 1.54, 95% CI = 1.04-2.13). There was no significant association between prediabetes and current nonsmoking in individuals with previous conventional cigarette use only. Among never-smokers, exposure to SHS significantly increased the risk of prediabetes (OR = 1.16, 95% CI = 1.04-1.30). Conclusions Mixed use of electronic and conventional cigarettes and exposure to SHS increased the risk of prediabetes. Further studies are required to comprehensively investigate the molecular biology underlying the effects of previous and current mixed use of electronic cigarettes and SHS on glucose metabolism.
Document Type: Article
Language: English
ISSN: 1945-7197
0021-972X
DOI: 10.1210/clinem/dgab558
Access URL: https://www.researchsquare.com/article/rs-373449/v1.pdf?c=1639887252000
https://pubmed.ncbi.nlm.nih.gov/34436592
https://www.researchsquare.com/article/rs-373449/v1.pdf?c=1631894624000
https://www.researchsquare.com/article/rs-373449/v1
https://europepmc.org/article/PPR/PPR305805
https://pubmed.ncbi.nlm.nih.gov/34436592/
Rights: OUP Standard Publication Reuse
CC BY
CC BY NC ND
Accession Number: edsair.doi.dedup.....2086e6c8c2ff054607b2073a78b11a27
Database: OpenAIRE
Description
Abstract:Context Despite previous studies regarding the association between smoking and diabetes, the effects of electronic cigarettes and secondhand smoke (SHS) on glucose metabolism and insulin sensitivity have not been fully elucidated. Objective To examine the association of mixed electronic and conventional cigarette use and exposure to SHS with prediabetes. Design Data from the 2014-2018 Korean National Health and Nutrition Examination Survey were analyzed. Setting Nationwide population-based. Participants Of 39 199 participants, 22 385 participants (9490 men, 12 895 women) without diabetes were included. The main independent variables were smoking behaviors, including exposure to SHS. Interventions None. Main Outcome Measures Prediabetes (hemoglobin A1C of 5.7-6.4%). Results Of 22 385 participants without diabetes, 6735 had prediabetes. Mixed cigarette use was associated with a 1.57-fold increase in the odds of prediabetes when compared with never-smoking [odds ratio (OR) = 1.57, 95% CI = 1.29-1.92] and a 1.27-fold increase when compared with conventional cigarette use only (OR = 1.27, 95% CI = 1.07-1.52). Participants who were current nonsmokers, but mixed users in the past had an increased risk of prediabetes (OR = 1.54, 95% CI = 1.04-2.13). There was no significant association between prediabetes and current nonsmoking in individuals with previous conventional cigarette use only. Among never-smokers, exposure to SHS significantly increased the risk of prediabetes (OR = 1.16, 95% CI = 1.04-1.30). Conclusions Mixed use of electronic and conventional cigarettes and exposure to SHS increased the risk of prediabetes. Further studies are required to comprehensively investigate the molecular biology underlying the effects of previous and current mixed use of electronic cigarettes and SHS on glucose metabolism.
ISSN:19457197
0021972X
DOI:10.1210/clinem/dgab558